Elife:晚期心脏淋巴管系统支持成年斑马鱼的心脏功能和再生

2020-10-02 MedSci原创 MedSci原创

一直以来,心脏淋巴管系统及其在心脏病患者中的潜在关键功能在很大程度上未没有得到充分的重视,部分原因是缺乏实验数据说明。

一直以来,心脏淋巴管系统及其在心脏病患者中的潜在关键功能在很大程度上未没有得到充分的重视,部分原因是缺乏实验数据说明。

本研究证明,年轻的成年斑马鱼中会形成心脏淋巴管,利用冠状动脉引导其向心室扩展。机制上,研究表明,在冠状动脉发育缺陷的xcr4a突变体中,心脏淋巴管未能扩展到心室。在再生的成年斑马鱼心脏中,淋巴管经历了广泛的淋巴细胞生成,以应对冷冻损伤。在Vegfc/Vegfr3信号转导受损的斑马鱼中,观察到冷冻损伤后减少疤痕大小的明显缺陷,这些斑马鱼不能发育出完整的心脏淋巴管。

综上所述,这些结果表明,心脏淋巴系统可以影响心肌的再生潜能。

 

原始出处:

 

Michael Rm HarrisonXidi Feng, et al., Late developing cardiac lymphatic vasculature supports adult zebrafish heart function and regeneration. Elife. 2019 Nov 8;8:e42762. doi: 10.7554/eLife.42762.

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    2021-08-29 膀胱癌
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    2021-03-10 clmlylxy
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    2020-10-04 lg.zhao
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    2020-10-04 amyloid

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