AJG:重新评估ALT正常上限有助于判断中国儿童慢性乙型肝炎病毒感染自然病程的发展

2019-02-23 不详 MedSci原创

目前血清丙氨酸氨基转移酶(ALT)的正常上限(ULN)受到越来越多的质疑。本项研究的目的是重新评估ALT的ULN,并评估它对儿童慢性乙型肝炎病毒(HBV)感染自然病程分类的潜在影响。

背景
目前血清丙氨酸氨基转移酶(ALT)的正常上限(ULN)受到越来越多的质疑。本项研究的目的是重新评估ALT的ULN,并评估它对儿童慢性乙型肝炎病毒(HBV)感染自然病程分类的潜在影响。

方法
本项研究回顾性分析了中国三家医院的实验室数据。总共有2054名患有慢性HBV感染儿童和8149名年龄≤18岁的健康儿童被纳入该研究。

结果
根据健康儿童的数据计算ALT的年龄特异性和性别特异性ULN数值,男孩平均为30 U / L,女孩平均为24 U / L. 使用修订的ULNs与当前的ULNs(40-50 U / L),在2054例HBV感染的儿童中有31-60%与9-17%的患者的ALT基线分析结果异常。516例HBV感染儿童的数据用于临床分期,28.8%的儿童分为乙型肝炎e抗原(HBeAg-)阳性/阴性肝炎阶段。

结论
儿童ALT的ULN数值的重新评估很有必要,准确的ALT上限能大大影响慢性HBV感染的自然病程分类。同时本项研究表明轻微的ALT波动在儿童期阶段很常见。

原始出处:

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    2019-09-26 shizhenshan
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    2019-10-24 minzju5052
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