BMJ:女性脂质水平与出血性卒中风险

2019-04-11 xing.T 网络

由此可见,LDL-C水平<70 mg/dL和低甘油三酯水平与女性出血性卒中风险增加有关。

近日,顶级杂志BMJ上发表了一篇研究文章,研究人员旨在评估女性血脂水平与出血性卒中风险之间的关系。

研究人员对参加女性健康研究的27937名女性进行了一项前瞻性队列研究,测量了她们的总胆固醇、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)以及甘油三酯水平。通过医疗记录审查确认了卒中情况。研究人员使用Cox比例风险模型来分析脂质类别与出血性卒中风险之间的关联。

平均随访19.3年,共出现137例出血性卒中患者。与LDL-C水平为100-129.9 mg/dL的患者相比,多变量调整后,LDL-C水平<70mg/dL的患者经历出血性卒中的风险为2.17倍(95%可信区间[CI]为1.05-4.48)。 LDL-C水平为130-159.9mg/dL(相对风险[RR]为1.14; 95%CI为0.72-1.80)或70-99.9mg/dL(RR为1.25; 95%CI为0.76-2.04)的风险没有显著增加。对LDL-C水平≥160mg/dL的患者(RR为1.53; 95%CI为0.92-2.52)风险增加,尽管并不显著。与多变量调整后最高四分位数的女性相比,甘油三酯水平为最低四分位数的女性出血性卒中风险显著增加(RR为2.00; 95%CI为1.18-3.39)。研究人员观察到总胆固醇或HDL-C水平与出血性卒中风险之间没有显著关联。

由此可见,LDL-C水平<70 mg/dL和低甘油三酯水平与女性出血性卒中风险增加有关。

原始出处:

Pamela M. Rist.et al.Lipid levels and the risk of hemorrhagic stroke among women.BMJ 2019;https://doi.org/10.1212/WNL.0000000000007454

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    2019-10-30 gaoxiaoe
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    2019-04-27 一天没事干

    很好的学习机会

    0

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    2019-04-11 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1848721, encodeId=6a7c1848e21ae, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Wed Oct 30 01:09:00 CST 2019, time=2019-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365357, encodeId=f44236535e75, content=很好的学习机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/12/cd30eefc465f70dc4dad89bd57479781.jpg, createdBy=02be2318568, createdName=一天没事干, createdTime=Sat Apr 27 11:28:42 CST 2019, time=2019-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1281310, encodeId=ff3e1281310b6, content=<a href='/topic/show?id=455f36085f0' target=_blank style='color:#2F92EE;'>#卒中风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36085, encryptionId=455f36085f0, topicName=卒中风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f1167, createdName=wmr111, createdTime=Sat Apr 13 04:09:00 CST 2019, time=2019-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1319565, encodeId=30c3131956559, content=<a href='/topic/show?id=1dc13145ef8' target=_blank style='color:#2F92EE;'>#出血性卒中#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31457, encryptionId=1dc13145ef8, topicName=出血性卒中)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4193478, createdName=wgx306, createdTime=Sat Apr 13 04:09:00 CST 2019, time=2019-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026338, encodeId=f0361026338a9, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Thu Apr 11 16:09:00 CST 2019, time=2019-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1045847, encodeId=2646104584e5e, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Thu Apr 11 16:09:00 CST 2019, time=2019-04-11, status=1, ipAttribution=)]
    2019-04-11 guging

    中风是俗称,应该称为缺血性卒中吧

    0

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