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Tiziana实现"肺部靶向递送"抗IL-6R单抗，以高效治疗新冠病毒COVID-19感染患者

2020-04-09 MedSci原创 MedSci原创

雾化器新冠病毒COVID-19抗IL-6R单抗
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Tiziana的这项技术可以使用手持吸入器或雾化器将抗IL-6受体（anti-IL-6R）单克隆抗体（mAb）TZLS-501直接递送到肺中。

Tiziana的这项技术可以使用手持吸入器或雾化器将抗IL-6受体（anti-IL-6R）单克隆抗体（mAb）TZLS-501直接递送到肺中。

该公司董事长Gabriele Cerrone说："使用便携式手持吸入器或雾化器将抗IL-6R mAb直接递送至肺部，对于感染了新型冠状病毒COVID-19的儿童和成人是一种快速、直接的治疗方法。"

"重要的是，用我们的全人源抗IL-6R mAb单抗有可能用于COVID-19感染患者的长期治疗，以阻止患者病情发展并降低死亡率。"

感染COVID-19的患者可能会产生不受控制的免疫反应（称为细胞因子风暴），从而导致促炎细胞因子和其他炎症蛋白的大量产生，如IL-6、肿瘤坏死因子-α（TNF-a）和粒细胞-巨噬细胞集落刺激因子（GM-CSF），引起肺组织的严重损伤，导致患者呼吸衰竭和死亡。

在这些细胞因子中，IL-6似乎是冠状病毒介导呼吸衰竭的主要元凶。国内医生进行的早期临床研究表明，抗IL6R mAb可能在临床实践中用于治疗COVID-19。

Tiziana认为TZLS-501（抗IL6R单抗）与这种新引入的吸入技术相结合可以迅速抑制肺部炎症。

原始出处：

http://www.pharmatimes.com/news/tiziana_develops_delivery_tech_for_covid-19_treatment_1338011

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    2020-10-14 AspirantSuo

    #ANA#

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    2021-01-28 yyanpro@21cn.c

    #新冠病毒COVID-19#

    0

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    2020-04-11 kzlchina

    #IL-6#

    0

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    2020-04-11 jklm09

    #IL-6R#

    0

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    2020-04-11 紫砂壶

    #抗IL-6R单抗#

    0

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    2020-04-10 公卫新人

    新冠肺炎，疫情何时才能消失

    0