Diabetes Care:美国糖尿病前期成人二甲双胍使用情况分析!

2017-04-04 xing.T MedSci原创

由此可见,在美国糖尿病前期的成人中二甲双胍使用率<1%,在那些有糖尿病的其他危险因素的个体中也只有稍微增加。

近日,糖尿病领域权威杂志Diabetes Care上发表了一研究文章,研究人员旨在采用2005年-2012年全国健康和营养调查(NHANES)来确定美国糖尿病前期成人使用二甲双胍的情况和特点。

美国糖尿病协会的针对糖尿病前期患者二甲双胍使用指南已经有所变化,2017年推荐糖尿病前期患者和其他危险因素(体重指数超过35kg/m2,年龄<60岁,或早期妊娠期糖尿病)或糖化血红蛋白(HbA1c)上升的患者服用二甲双胍。研究人员估计在糖尿病前期的个人中(定义为HbA1c在5.7-6.4%,空腹血糖100-125mg/dL,餐后2小时血糖为140-199mg/dL或自我报告)年龄调整后二甲双胍使用情况,并采用多因素Logistic回归评估二甲双胍使用的相关特征。

在22174名成人中,7652名参与者处于糖尿病前期。年龄调整后糖尿病前期患者中二甲双胍的使用率为0.7%。使用二甲双胍与较高的平均BMI(35.1 kg/m2 vs. 29.6 kg/m2,P<0.01)和较高的血糖(空腹血糖114mg/dL vs. 105mg/dL,P=0.03;餐后2小时血糖155mg/dL vs. 128mg/dL,P=0.003;HbA1c 6% [42mmol/nmol] vs. 5.6% [38mmol/mmol],P<0.01)相关。即使在那些BMI≥35kg/m2、推荐服用二甲双胍的参与者中,二甲双胍的使用率也较低。二甲双胍的使用并没有因种族、贫困收入比或教育而有所不同。

由此可见,在美国糖尿病前期的成人中二甲双胍使用率<1%,在那些有糖尿病的其他危险因素的个体中也只有稍微增加。

原始出处:

Eva Tseng, et al. Metformin Use in Prediabetes Among U.S. Adults, 2005–2012. Diabetes Care 2017 Apr; dc161509. https://doi.org/10.2337/dc16-1509

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  5. 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    2017-04-06 1e1263e3m20(暂无匿称)

    学习了,多谢分享

    0

  6. 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    2017-04-06 cqykthl

    二甲双胍在2型糖尿病属于一线药物。

    0

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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er7lBrMCuvxicCR3XJQhu2X3SmEzicSFDknz19Vav0ln3PHYSicIKQRIiazzcibtEchpeQNrjh2jfOYC0w/132, createdBy=eb931929187, createdName=美丽明天在等我, createdTime=Wed Apr 05 00:42:22 CST 2017, time=2017-04-05, status=1, ipAttribution=)]
    2017-04-05 虈亣靌

    这篇文章对我有用,值得收藏!

    0

  8. 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likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1ab1619415, createdName=lecoo, createdTime=Wed Apr 05 06:54:43 CST 2017, time=2017-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185226, encodeId=015c185226dc, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Wed Apr 05 01:19:32 CST 2017, time=2017-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185220, encodeId=44e21852208a, content=二甲双胍在我们国家应用还是比较多的, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er7lBrMCuvxicCR3XJQhu2X3SmEzicSFDknz19Vav0ln3PHYSicIKQRIiazzcibtEchpeQNrjh2jfOYC0w/132, createdBy=eb931929187, createdName=美丽明天在等我, createdTime=Wed Apr 05 00:42:22 CST 2017, time=2017-04-05, status=1, ipAttribution=)]
    2017-04-05 lecoo

    二甲双胍的使用长远效应还不是很明确,在我国使用量很大

    0

  9. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er7lBrMCuvxicCR3XJQhu2X3SmEzicSFDknz19Vav0ln3PHYSicIKQRIiazzcibtEchpeQNrjh2jfOYC0w/132, createdBy=eb931929187, createdName=美丽明天在等我, createdTime=Wed Apr 05 00:42:22 CST 2017, time=2017-04-05, status=1, ipAttribution=)]
    2017-04-05 飛歌

    学习了很有用

    0

  10. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er7lBrMCuvxicCR3XJQhu2X3SmEzicSFDknz19Vav0ln3PHYSicIKQRIiazzcibtEchpeQNrjh2jfOYC0w/132, createdBy=eb931929187, createdName=美丽明天在等我, createdTime=Wed Apr 05 00:42:22 CST 2017, time=2017-04-05, status=1, ipAttribution=)]
    2017-04-05 美丽明天在等我

    二甲双胍在我们国家应用还是比较多的

    0

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PLoS One:佛罗里达州18岁以上成人糖尿病前期和糖尿病发生和预测因子

背景:糖尿病前期和糖尿病的患者形成大血管并发症的风险增加,包括心脏病和卒中;这是导致全球死亡的主要原因。本研究的目的是评估糖尿病前期和糖尿病的患病率,并探讨佛罗里达州18年以上成人中的预测因子。方法:数据从佛罗里达州的行为危险因素监测系统(BRFSS)获得,时间为2013年1月至12月。调查研究由Stata 13.1中SVYSEY设计。描述性分析,评估糖尿病前期和糖尿病患者的发生率。应用多元回归模

J Am Board Fam Med:糖尿病前期的诊断及治疗

糖尿病的患病率逐渐升高并成为威胁人类健康的主要问题之一,因此糖尿病前期的诊断及治疗有助于预防或延缓糖尿病的起病。研究人员从2012年全国非卧床病人医疗护理调查(NAMCS)中选取了年龄≥45岁、未诊断为糖尿病、90天内检测过HbA1c的患者进行随访。按HbA1c的结果分为正常、糖尿病前期和糖尿病,并收集患者的个人信息,包括年龄、性别、纳税人类型、种族、BMI等,以及关于糖尿病前期的治疗。研究结果显

BMJ:糖尿病前期与心血管疾病风险和全因死亡率之间的关系

糖尿病前期,被定义为糖耐量受损、空腹血糖受损或升高的HbA1c,与增加的心血管疾病风险相关。空腹血糖浓度低于5.6 mmol/L或HbA1c低于39mmol/mol的个人健康风险也可能增加。

Ann Fam Med:BMI正常范围内的糖尿病前期和腹型肥胖率大幅增加

近期发表在Annals of Family Medicine的数据显示,从1988到2012年,健康体重范围内的糖尿病前期和腹部肥胖率大幅增加。盖恩斯维尔佛罗里达大学的Arch G. Mainous III博士对1988-1994年和1999-2012年的全国健康和营养调查(NHANES)进行了分析,探究健康体重成年人的糖尿病前期和腹部肥胖率。研究人员集中研究≥20岁BMI在18.5-24.99,

Lancet Diabetes Endocrinol:糖化血红蛋白比血糖能更好地预测糖尿病前期风险

这对医生来说是很重要的信息,同时对专业的组织来说也是很重要的信息。对糖尿病前期进行如何定义和诊断即将达成全球共识,这将有助于移动该领域向前发展,以及帮助世界各地的糖尿病前期患者。

J Clin Endocrinol Metab:PDE5抑制剂可改善糖尿病前期患者胰岛素敏感性

一项新的研究发现勃起功能障碍药物西地那非(伟哥)改善糖尿病前期患者的胰岛素敏感性和内皮功能标志物状态。研究结果11月18日在线发表在Journal of Clinical Endocrinology and Metabolism。