Stroke:吸烟会影响急性缺血性脑卒中后功能状态吗?

2020-07-09 shaosai MedSci原创

吸烟是脑卒中相对明确的风险指标;然而,是否脑卒中前吸烟状态是否会影响急性缺血性脑卒中后的临床预后尚不明确。本研究旨在探究吸烟状态与急性缺血性脑卒中后功能状态的相关性。

背景与目的

吸烟是脑卒中相对明确的风险指标;然而,是否脑卒中前吸烟状态是否会影响急性缺血性脑卒中后的临床预后尚不明确。本研究旨在探究吸烟状态与急性缺血性脑卒中后功能状态的相关性。

方法

本研究纳入了10825例急性缺血性脑卒中患者。根据吸烟史将患者分为非吸烟者、以往吸烟者和正在吸烟者。临床预后包括神经功能预后较差(mRS评分为≥2)和神经功能较好(mRS评分为2-5)。利用回归分析对潜在协变量进行调整。

结果

患者平均年龄为70.2±12.2岁,37.0%为女性患者。非吸烟者、以往吸烟者和现存吸烟者分别为4396 (42.7%) 、3328 (32.4%) 和2561 (24.9%)。与非吸烟者相比,经调整协变量后现存吸烟者神经功能恢复较差风险的OR升高(现存吸烟者与非吸烟者相比OR为1.29 [1.11-1.49]),但以往吸烟者并无变化(以往吸烟者与非吸烟者相比OR为1.05 [0.92-1.21])。然而,在以往吸烟者中,在脑卒中发病2年内戒烟的患者的神经功能恢复较差的OR值要明显升高(与非吸烟者相比OR值为1.75 [1.15-2.66])。在现存吸烟者患者中,神经功能恢复较差的风险会随着日常吸烟量增加而增加(P for trend=0.002)。对于神经功能恢复较高同样有类似相关性。

结论

急性缺血性脑卒中患者仍旧吸烟及近期有吸烟史与不良神经功能障碍发生风险具有相关性。

原始出处:

Matsuo R, Ago T, Kiyuna F et al.Smoking Status and Functional Outcomes After Acute Ischemic Stroke.DOI:10.1161/STROKEAHA.119.027230

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  6. [GetPortalCommentsPageByObjectIdResponse(id=1807243, encodeId=3971180e2430c, content=<a href='/topic/show?id=6eade9380cb' target=_blank style='color:#2F92EE;'>#缺血性脑卒中后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79380, encryptionId=6eade9380cb, topicName=缺血性脑卒中后)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b3ad2500191, createdName=12498dd9m11暂无昵称, createdTime=Tue Aug 18 22:54:30 CST 2020, time=2020-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1671411, encodeId=7ba716e14119a, content=<a href='/topic/show?id=9f4e360191a' target=_blank style='color:#2F92EE;'>#卒中后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36019, encryptionId=9f4e360191a, topicName=卒中后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff7426824786, createdName=waiwai3039, createdTime=Sun May 02 14:54:30 CST 2021, time=2021-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1807142, encodeId=09ca180e14231, content=<a href='/topic/show?id=245de9378aa' target=_blank style='color:#2F92EE;'>#缺血性脑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79378, encryptionId=245de9378aa, topicName=缺血性脑)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLGtr9t89oicQdQSIeKmOQic1weIWfibJ7H24XnT8ic9wiaUMTnXByenuwicOj8Jib42ibHXNptnuiaKthhiaVw/132, createdBy=ac342500190, createdName=ms7524819409032184, createdTime=Mon Jan 25 08:54:30 CST 2021, time=2021-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1893310, encodeId=6f8518933107e, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Fri Mar 12 16:54:30 CST 2021, time=2021-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1259411, encodeId=8f3b1259411e7, content=<a href='/topic/show?id=5679523e201' target=_blank style='color:#2F92EE;'>#急性缺血性脑卒中#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52372, encryptionId=5679523e201, topicName=急性缺血性脑卒中)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Sat Jul 11 01:54:30 CST 2020, time=2020-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622935, encodeId=5453162293520, content=<a href='/topic/show?id=abff3292584' target=_blank style='color:#2F92EE;'>#功能状态#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32925, encryptionId=abff3292584, topicName=功能状态)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sat Jul 11 01:54:30 CST 2020, time=2020-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=801952, encodeId=540a8019523f, content=<a href='/topic/show?id=fa10e93597f' target=_blank style='color:#2F92EE;'>#缺血性卒中#</a>吸烟饮酒都会有影响,虽然影响并不大。, beContent=null, objectType=article, channel=null, level=null, likeNumber=198, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79359, encryptionId=fa10e93597f, topicName=缺血性卒中)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Jul 09 22:18:15 CST 2020, time=2020-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026668, encodeId=9b59102666866, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Thu Jul 09 13:54:30 CST 2020, time=2020-07-09, status=1, ipAttribution=)]
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    2020-07-09 lovetcm

    #缺血性卒中#吸烟饮酒都会有影响,虽然影响并不大。

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1807243, encodeId=3971180e2430c, content=<a href='/topic/show?id=6eade9380cb' target=_blank style='color:#2F92EE;'>#缺血性脑卒中后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79380, encryptionId=6eade9380cb, topicName=缺血性脑卒中后)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b3ad2500191, createdName=12498dd9m11暂无昵称, createdTime=Tue Aug 18 22:54:30 CST 2020, time=2020-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1671411, encodeId=7ba716e14119a, content=<a href='/topic/show?id=9f4e360191a' target=_blank style='color:#2F92EE;'>#卒中后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36019, encryptionId=9f4e360191a, topicName=卒中后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff7426824786, createdName=waiwai3039, createdTime=Sun May 02 14:54:30 CST 2021, time=2021-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1807142, encodeId=09ca180e14231, content=<a href='/topic/show?id=245de9378aa' target=_blank style='color:#2F92EE;'>#缺血性脑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79378, encryptionId=245de9378aa, topicName=缺血性脑)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLGtr9t89oicQdQSIeKmOQic1weIWfibJ7H24XnT8ic9wiaUMTnXByenuwicOj8Jib42ibHXNptnuiaKthhiaVw/132, createdBy=ac342500190, createdName=ms7524819409032184, createdTime=Mon Jan 25 08:54:30 CST 2021, time=2021-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1893310, encodeId=6f8518933107e, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Fri Mar 12 16:54:30 CST 2021, time=2021-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1259411, encodeId=8f3b1259411e7, content=<a href='/topic/show?id=5679523e201' target=_blank style='color:#2F92EE;'>#急性缺血性脑卒中#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52372, encryptionId=5679523e201, topicName=急性缺血性脑卒中)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Sat Jul 11 01:54:30 CST 2020, time=2020-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622935, encodeId=5453162293520, content=<a href='/topic/show?id=abff3292584' target=_blank style='color:#2F92EE;'>#功能状态#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32925, encryptionId=abff3292584, topicName=功能状态)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sat Jul 11 01:54:30 CST 2020, time=2020-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=801952, encodeId=540a8019523f, content=<a href='/topic/show?id=fa10e93597f' target=_blank style='color:#2F92EE;'>#缺血性卒中#</a>吸烟饮酒都会有影响,虽然影响并不大。, beContent=null, objectType=article, channel=null, level=null, likeNumber=198, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79359, encryptionId=fa10e93597f, topicName=缺血性卒中)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Jul 09 22:18:15 CST 2020, time=2020-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026668, encodeId=9b59102666866, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Thu Jul 09 13:54:30 CST 2020, time=2020-07-09, status=1, ipAttribution=)]
    2020-07-09 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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