Prostate:M2a巨噬细胞能够恢复良性前列腺增生上皮细胞和基质细胞的增殖和基因表达

2021-05-03 AlexYang MedSci原创

良性前列腺增生(BPH)是老年男性的一种常见疾病,通常伴有慢性炎症。巨噬细胞(包括几种亚型)是浸润增生前列腺的主要炎症细胞,能够分泌细胞因子和生长因子。

良性前列腺增生(BPH)是老年男性的一种常见疾病,通常伴有慢性炎症。巨噬细胞(包括几种亚型)是浸润增生前列腺的主要炎症细胞,能够分泌细胞因子和生长因子。

最近,有研究人员调查了M2a巨噬细胞通过胰岛素样生长因子1(IGF-1)对BPH发展的影响

研究人员使用了人类前列腺组织、前列腺和单核细胞系(WPMY-1、BPH-1和THP-1),并使用细胞因子将THP-1极化为几种亚型。研究人员通过扩增巨噬细胞的特异性标志物,验证了巨噬细胞的极化亚型。研究人员发现,M2a巨噬细胞明显地增强了前列腺细胞的增殖,CD206在增生的前列腺中表达更多。IGF-1在前列腺上皮和基质成分中都有定位,且在前列腺增生组织中上调。M2a巨噬细胞比其他亚型表达了更多的IGF-1。在WPMY-1和BPH-1细胞中敲除IGF-1减弱了细胞增殖,促进了细胞凋亡,延缓G0/G1期的细胞周期,并抑制了BPH-1细胞的EMT过程以及WPMY-1细胞的纤维化过程,当与M2a巨噬细胞共培养时,这种作用是可逆转的。

M2a巨噬细胞对WPMY-1细胞的细胞周期,细胞凋亡和细胞增值影响

最后,研究人员指出,在培养的BPH上皮细胞和基质细胞中敲除IGF-1的表达可以减少增殖和增加凋亡这些影响可通过与M2a巨噬细胞共培养而逆转

原始出处:

Qiaofeng Qian, Weixiang He, Daoquan Liu et al. M2a macrophage can rescue proliferation and gene expression of benign prostate hyperplasia epithelial and stroma cells from insulin-like growth factor 1 knockdown. Prostate. Apr 2021

 

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    2021-05-05 njwbhuang

    非常好的文献,学习了

    0

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    2021-05-05 lsndxfj
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    2021-05-05 sunylz

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