IBD:基质金属蛋白酶3可以预测英夫利昔单抗治疗的炎症性肠病患者的治疗反应

2020-04-12 MedSci原创 MedSci原创

炎症性肠病(IBD)使用抗TNF药物治疗,以前的证据表明,基质金属蛋白酶3(MMP3)对英夫利昔单抗(IFX)的作用是导致丧失治疗应答的一种机制。

背景和目标:炎症性肠病(IBD)使用抗TNF药物治疗,以前的证据表明,基质金属蛋白酶3(MMP3)对英夫利昔单抗(IFX)的作用是导致丧失治疗应答的一种机制。本项研究旨在评估MMP3血清水平是否可被视为抗TNF无反应的早期标志物,并分析与治疗失败的其他生化标志物(如IFX谷水平和抗IFX抗体,炎性标志物和白蛋白水平)的相关性。

方法:本项研究回顾性分析了73名接受IFX至少1年的IBD患者:在52周时有35例有反应,38例无反应。在基线时评估了患者的临床和生化数据(Harvey-Bradshaw指数[HBI],Mayo得分,体重指数[BMI],C反应蛋白[CRP],粪便钙卫蛋白和白蛋白水平),MMP3血清水平。

结果:研究发现MMP3水平在基线时相似(19.83 vs.17.92 ng / mL),但是在诱导后,在一年后未反应的患者的水平显着高于响应的患者(26.09 vs 8.68 ng / mL,P <0.001);在第52周时确认了差异(29.56 vs 11.48 ng / mL,P <0.001)。在诱导后和52周时,未使用抗药物抗体的患者的MMP3水平倾向于高于使用抗药物抗体的患者。

结论:MMP3血清测定可能可以预测英夫利昔单抗的早期反应。

原始出处:

Brigida Barberio. Et al. Matrix Metalloproteinase 3 Predicts Therapeutic Response in Inflammatory Bowel Disease Patients Treated With Infliximab. Inflammatory Bowel Diseases.2020.

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    2021-01-05 canlab
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    2020-04-14 bnurmamat
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