J Oral Implantol:比较多孔钽骨小梁金属和钛合金材料的初始伤口愈合和成骨

2019-01-25 MedSci MedSci原创

多孔钽骨小梁金属(PTTM)长期以来一直用于整形外科,以增强新血管形成,伤口愈合和成骨,最近它已被纳入钛合金牙科植入物中。然而,关于人口腔中PTTM的生物反应知之甚少。我们假设,与传统的钛合金相比,在初始愈合期间,PTTM具有更高的新血管形成,伤口愈合和成骨特异性基因表达。研究招募了12名需要至少4个下颌骨植入物的受试者。使用分口设计将四个3mmx5mm装置(包括2个钛合金锥形螺钉和2个PTTM圆

多孔钽骨小梁金属(PTTM)长期以来一直用于整形外科,以增强新血管形成,伤口愈合和成骨,最近它已被纳入钛合金牙科植入物中。然而,关于人口腔中PTTM的生物反应知之甚少。我们假设,与传统的钛合金相比,在初始愈合期间,PTTM具有更高的新血管形成,伤口愈合和成骨特异性基因表达。

研究招募了12名需要至少4个下颌骨植入物的受试者。使用分口设计将四个3mmx5mm装置(包括2个钛合金锥形螺钉和2个PTTM圆柱体)放置在无牙下颌区域中。在放置后2周和4周时,每组中的一个装置被环钻取出以进行分析。RNA微阵列分析和独创性通路分析用于分析成骨基因表达和相关信号传导通路。

结果显示,与钛合金相比,PTTM样品显示出对细胞新血管形成,伤口愈合和成骨特异性的基因的明显更高的表达。与钛合金对照相比,PTTM组中包括骨形态发生蛋白,胶原蛋白和生长因子在内的几种基因的表达上调。

综上所述,该研究结果表明,PTTM材料可通过修饰基因表达谱来增强牙植入物的初始愈合。

原始出处:

Bencharit S, Morelli T, et al., Comparing initial wound healing and osteogenesis of porous tantalum trabecular metal and titanium alloy materials. J Oral Implantol. 2019 Jan 21. doi: 10.1563/aaid-joi-D-17-00258.

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    2019-05-12 xuyong536
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    2019-03-23 小几洁
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2019, time=2019-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309888, encodeId=941c1309888d2, content=<a href='/topic/show?id=5e6926003ae' target=_blank style='color:#2F92EE;'>#伤口愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26003, encryptionId=5e6926003ae, topicName=伤口愈合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Sun Jan 27 14:39:00 CST 2019, time=2019-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351973, encodeId=b2cf13519e3e3, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Jan 27 14:39:00 CST 2019, time=2019-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465409, encodeId=ff661465409b2, content=<a href='/topic/show?id=662a388823e' target=_blank style='color:#2F92EE;'>#合金#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38882, encryptionId=662a388823e, topicName=合金)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=81df6719716, createdName=楚秀娟, createdTime=Sun Jan 27 14:39:00 CST 2019, time=2019-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592210, encodeId=60ce159221008, content=<a href='/topic/show?id=2abe96399a8' target=_blank style='color:#2F92EE;'>#钛合金#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96399, encryptionId=2abe96399a8, topicName=钛合金)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=59b918104146, createdName=swallow, createdTime=Sun Jan 27 14:39:00 CST 2019, time=2019-01-27, status=1, ipAttribution=)]
    2019-12-24 30397613
  5. [GetPortalCommentsPageByObjectIdResponse(id=1773261, encodeId=b5211e7326132, content=<a href='/topic/show?id=5298121e46e' target=_blank style='color:#2F92EE;'>#MPL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12174, encryptionId=5298121e46e, topicName=MPL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10e638510530, createdName=xuyong536, createdTime=Sun May 12 05:39:00 CST 2019, time=2019-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2076312, encodeId=fb9a20e6312f2, content=<a href='/topic/show?id=e7fd10164380' target=_blank style='color:#2F92EE;'>#骨小梁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101643, encryptionId=e7fd10164380, topicName=骨小梁)], attachment=null, authenticateStatus=null, 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encodeId=7b1116e9756c6, content=<a href='/topic/show?id=d4ac9639efa' target=_blank style='color:#2F92EE;'>#钛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96397, encryptionId=d4ac9639efa, topicName=钛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=927227807332, createdName=30397613, createdTime=Tue Dec 24 14:39:00 CST 2019, time=2019-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789241, encodeId=2d3b1e89241d3, content=<a href='/topic/show?id=0c8814344f5' target=_blank style='color:#2F92EE;'>#plant#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14344, encryptionId=0c8814344f5, topicName=plant)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f5b299, createdName=xuyu, createdTime=Wed Oct 09 15:39:00 CST 2019, time=2019-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309888, encodeId=941c1309888d2, content=<a href='/topic/show?id=5e6926003ae' target=_blank style='color:#2F92EE;'>#伤口愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26003, encryptionId=5e6926003ae, topicName=伤口愈合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Sun Jan 27 14:39:00 CST 2019, time=2019-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351973, encodeId=b2cf13519e3e3, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Jan 27 14:39:00 CST 2019, time=2019-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465409, encodeId=ff661465409b2, content=<a href='/topic/show?id=662a388823e' target=_blank style='color:#2F92EE;'>#合金#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38882, encryptionId=662a388823e, topicName=合金)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=81df6719716, createdName=楚秀娟, createdTime=Sun Jan 27 14:39:00 CST 2019, time=2019-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592210, encodeId=60ce159221008, content=<a href='/topic/show?id=2abe96399a8' target=_blank style='color:#2F92EE;'>#钛合金#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96399, encryptionId=2abe96399a8, topicName=钛合金)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=59b918104146, createdName=swallow, createdTime=Sun Jan 27 14:39:00 CST 2019, time=2019-01-27, status=1, ipAttribution=)]
    2019-10-09 xuyu
  6. 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2019, time=2019-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309888, encodeId=941c1309888d2, content=<a href='/topic/show?id=5e6926003ae' target=_blank style='color:#2F92EE;'>#伤口愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26003, encryptionId=5e6926003ae, topicName=伤口愈合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Sun Jan 27 14:39:00 CST 2019, time=2019-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351973, encodeId=b2cf13519e3e3, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, 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topicId=null, topicList=[TopicDto(id=96399, encryptionId=2abe96399a8, topicName=钛合金)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=59b918104146, createdName=swallow, createdTime=Sun Jan 27 14:39:00 CST 2019, time=2019-01-27, status=1, ipAttribution=)]
  7. 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2019, time=2019-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309888, encodeId=941c1309888d2, content=<a href='/topic/show?id=5e6926003ae' target=_blank style='color:#2F92EE;'>#伤口愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26003, encryptionId=5e6926003ae, topicName=伤口愈合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Sun Jan 27 14:39:00 CST 2019, time=2019-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351973, encodeId=b2cf13519e3e3, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Jan 27 14:39:00 CST 2019, time=2019-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465409, encodeId=ff661465409b2, content=<a href='/topic/show?id=662a388823e' target=_blank style='color:#2F92EE;'>#合金#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38882, encryptionId=662a388823e, topicName=合金)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=81df6719716, createdName=楚秀娟, createdTime=Sun Jan 27 14:39:00 CST 2019, time=2019-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592210, encodeId=60ce159221008, content=<a href='/topic/show?id=2abe96399a8' target=_blank style='color:#2F92EE;'>#钛合金#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96399, encryptionId=2abe96399a8, topicName=钛合金)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=59b918104146, createdName=swallow, createdTime=Sun Jan 27 14:39:00 CST 2019, time=2019-01-27, status=1, ipAttribution=)]
    2019-01-27 zhaojie88
  8. 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2019, time=2019-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309888, encodeId=941c1309888d2, content=<a href='/topic/show?id=5e6926003ae' target=_blank style='color:#2F92EE;'>#伤口愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26003, encryptionId=5e6926003ae, topicName=伤口愈合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Sun Jan 27 14:39:00 CST 2019, time=2019-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351973, encodeId=b2cf13519e3e3, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Jan 27 14:39:00 CST 2019, time=2019-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465409, encodeId=ff661465409b2, content=<a href='/topic/show?id=662a388823e' target=_blank style='color:#2F92EE;'>#合金#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38882, encryptionId=662a388823e, topicName=合金)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=81df6719716, createdName=楚秀娟, createdTime=Sun Jan 27 14:39:00 CST 2019, time=2019-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592210, encodeId=60ce159221008, content=<a href='/topic/show?id=2abe96399a8' target=_blank style='color:#2F92EE;'>#钛合金#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96399, encryptionId=2abe96399a8, topicName=钛合金)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=59b918104146, createdName=swallow, createdTime=Sun Jan 27 14:39:00 CST 2019, time=2019-01-27, status=1, ipAttribution=)]
    2019-01-27 楚秀娟
  9. 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2019, time=2019-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309888, encodeId=941c1309888d2, content=<a href='/topic/show?id=5e6926003ae' target=_blank style='color:#2F92EE;'>#伤口愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26003, encryptionId=5e6926003ae, topicName=伤口愈合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Sun Jan 27 14:39:00 CST 2019, time=2019-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351973, encodeId=b2cf13519e3e3, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, 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topicId=null, topicList=[TopicDto(id=96399, encryptionId=2abe96399a8, topicName=钛合金)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=59b918104146, createdName=swallow, createdTime=Sun Jan 27 14:39:00 CST 2019, time=2019-01-27, status=1, ipAttribution=)]
    2019-01-27 swallow