Arthritis Rheumatol:无膝关节疼痛的膝关节骨关节炎患者的疼痛易感性表型

2018-10-16 xiangting MedSci原创

确定了4个PSPs,其中3个以QST致敏证据为主,1个与2年后出现PKP相关。

为什么有些膝关节骨关节炎(OA)患者会出现疼痛尚不清楚。这项研究试图在2年后确定疼痛易感性表型(PSPs)及其与持续性膝关节疼痛(PKP)的关联。

研究人员从多中心骨关节炎研究中查找无PKP个体,多中心骨关节炎研究是一个患膝关节OA或有膝关节OA风险的老年纵向队列。使用潜伏组分析确定除了结构病理以外可能导致PKP的PSPs:广泛性疼痛、睡眠不佳、心理因素和定量感觉测试(QST)(即压力疼痛阈值和继时性的总和(TS))。研究人员通过logistic回归评估了社会人口学因素与PSPs的相关性以及PSPs与两年内出现PKP的关联。

纳入852名受试者(平均年龄67岁; BMI 29.5kg/m2,55%为女性)。确定了4种PSPs,主要表现为存在不同比例的压力疼痛敏感性和促进TS(低/无、中或高),压力疼痛敏感性和促进TS是反映致敏性的不同指标。与两种指标致敏比例低的PSP相比,压力疼痛敏感性比例高+促进TS比例中等的PSP在2年内出现偶发性PKP的可能性是两倍,OR 2.11(95%CI 1.06 4.22)。

确定了4个PSPs,其中3个以QST致敏证据为主,1个与2年后出现PKP相关。预防或改善致敏可能是预防OA持续性膝关节疼痛发作的新方法。

原始出处:

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    2019-06-03 lisa438
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createdName=dangious, createdTime=Tue Feb 26 12:54:00 CST 2019, time=2019-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1986824, encodeId=57c619868241e, content=<a href='/topic/show?id=6b393012106' target=_blank style='color:#2F92EE;'>#关节疼痛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30121, encryptionId=6b393012106, topicName=关节疼痛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Fri Sep 20 20:54:00 CST 2019, time=2019-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1972549, encodeId=711f19e254912, content=<a href='/topic/show?id=8a6a2e8839' target=_blank style='color:#2F92EE;'>#Arthritis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2788, encryptionId=8a6a2e8839, topicName=Arthritis)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Wed Jul 31 15:54:00 CST 2019, time=2019-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265820, encodeId=983d12658202a, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Wed Oct 17 23:54:00 CST 2018, time=2018-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356957, encodeId=6c37135695ee7, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Oct 17 23:54:00 CST 2018, time=2018-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460555, encodeId=11321460555bd, content=<a href='/topic/show?id=36a7596628a' target=_blank style='color:#2F92EE;'>#易感性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59662, encryptionId=36a7596628a, topicName=易感性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f6af6344165, createdName=FukaiBao, createdTime=Wed Oct 17 23:54:00 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authenticateStatus=null, createdAvatar=null, createdBy=7e7b16514606, createdName=ms306040998833292, createdTime=Wed Oct 17 23:54:00 CST 2018, time=2018-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349532, encodeId=e25c3495322d, content=学习了,涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Tue Oct 16 13:17:38 CST 2018, time=2018-10-16, status=1, ipAttribution=)]
  5. 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createdName=dangious, createdTime=Tue Feb 26 12:54:00 CST 2019, time=2019-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1986824, encodeId=57c619868241e, content=<a href='/topic/show?id=6b393012106' target=_blank style='color:#2F92EE;'>#关节疼痛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30121, encryptionId=6b393012106, topicName=关节疼痛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Fri Sep 20 20:54:00 CST 2019, time=2019-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1972549, encodeId=711f19e254912, content=<a href='/topic/show?id=8a6a2e8839' target=_blank style='color:#2F92EE;'>#Arthritis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2788, encryptionId=8a6a2e8839, topicName=Arthritis)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Wed Jul 31 15:54:00 CST 2019, time=2019-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265820, encodeId=983d12658202a, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Wed Oct 17 23:54:00 CST 2018, time=2018-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356957, encodeId=6c37135695ee7, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Oct 17 23:54:00 CST 2018, time=2018-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460555, encodeId=11321460555bd, content=<a href='/topic/show?id=36a7596628a' target=_blank style='color:#2F92EE;'>#易感性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59662, encryptionId=36a7596628a, topicName=易感性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f6af6344165, createdName=FukaiBao, createdTime=Wed Oct 17 23:54:00 CST 2018, time=2018-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535191, encodeId=87c41535191c1, content=<a href='/topic/show?id=099f9020145' target=_blank style='color:#2F92EE;'>#表型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90201, encryptionId=099f9020145, topicName=表型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6412593156, createdName=tastas, createdTime=Wed Oct 17 23:54:00 CST 2018, time=2018-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579399, encodeId=632d15e93992c, content=<a href='/topic/show?id=78ec85884e7' target=_blank style='color:#2F92EE;'>#膝关节骨关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85884, encryptionId=78ec85884e7, topicName=膝关节骨关节炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e7b16514606, createdName=ms306040998833292, createdTime=Wed Oct 17 23:54:00 CST 2018, time=2018-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349532, encodeId=e25c3495322d, content=学习了,涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Tue Oct 16 13:17:38 CST 2018, time=2018-10-16, status=1, ipAttribution=)]
    2018-10-17 lmm397
  6. 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CST 2018, time=2018-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535191, encodeId=87c41535191c1, content=<a href='/topic/show?id=099f9020145' target=_blank style='color:#2F92EE;'>#表型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90201, encryptionId=099f9020145, topicName=表型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6412593156, createdName=tastas, createdTime=Wed Oct 17 23:54:00 CST 2018, time=2018-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579399, encodeId=632d15e93992c, content=<a href='/topic/show?id=78ec85884e7' target=_blank style='color:#2F92EE;'>#膝关节骨关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85884, encryptionId=78ec85884e7, topicName=膝关节骨关节炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e7b16514606, createdName=ms306040998833292, createdTime=Wed Oct 17 23:54:00 CST 2018, time=2018-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349532, encodeId=e25c3495322d, content=学习了,涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Tue Oct 16 13:17:38 CST 2018, time=2018-10-16, status=1, ipAttribution=)]
    2018-10-17 zhaojie88
  7. 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  8. 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CST 2018, time=2018-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535191, encodeId=87c41535191c1, content=<a href='/topic/show?id=099f9020145' target=_blank style='color:#2F92EE;'>#表型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90201, encryptionId=099f9020145, topicName=表型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6412593156, createdName=tastas, createdTime=Wed Oct 17 23:54:00 CST 2018, time=2018-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579399, encodeId=632d15e93992c, content=<a href='/topic/show?id=78ec85884e7' target=_blank style='color:#2F92EE;'>#膝关节骨关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85884, encryptionId=78ec85884e7, topicName=膝关节骨关节炎)], attachment=null, 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    2018-10-17 tastas
  9. 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authenticateStatus=null, createdAvatar=null, createdBy=7e7b16514606, createdName=ms306040998833292, createdTime=Wed Oct 17 23:54:00 CST 2018, time=2018-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349532, encodeId=e25c3495322d, content=学习了,涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Tue Oct 16 13:17:38 CST 2018, time=2018-10-16, status=1, ipAttribution=)]
    2018-10-16 王秀

    学习了,涨知识了!

    0