Bioact Mater:粉末冶金Ti-Mg金属 - 金属复合材料促进骨传导和骨整合可用于整形外科应用

2018-12-29 MedSci MedSci原创

在这项工作中,通过放电等离子烧结(SPS)成功地制造了Ti-Mg金属-金属复合材料(MMCs)。 在体外,研究了SaOS-2细胞对Ti-Mg金属-金属复合物(MMCs)的增殖和分化。 在体内,使用具有股骨髁缺损的大鼠模型,并且将Ti-Mg MMCs植入物嵌入股骨髁中。结果表明,与纯Ti相比,Ti-Mg MMCs对SaOS-2细胞的细胞相容性增强。微型计算机断层扫描(Micro-CT)结果显示,Ti

在这项工作中,通过放电等离子烧结(SPS)成功地制造了Ti-Mg金属-金属复合材料(MMCs)。 在体外,研究了SaOS-2细胞对Ti-Mg金属-金属复合物(MMCs)的增殖和分化。

在体内,使用具有股骨髁缺损的大鼠模型,并且将Ti-Mg MMCs植入物嵌入股骨髁中。结果表明,与纯Ti相比,Ti-Mg MMCs对SaOS-2细胞的细胞相容性增强。微型计算机断层扫描(Micro-CT)结果显示,Ti-Mg种植体周围的骨小梁体积明显多于Ti种植体周围,表明Ti-Mg MMCs种植体周围形成更多活跃的新骨。苏木精-伊红(H&E)染色分析显示Ti-Mg植入物周围的骨整合明显大于Ti植入物周围的骨整合。

原始出处:

Sihui Ouyang, Qianli Huang, et al., Powder metallurgical Ti-Mg metal-metal composites facilitate osteoconduction and osseointegration for orthopedic application. Bioact Mater. 2019 Mar; 4(1): 37–42.

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    2019-11-18 sunylz
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