Diabet Med:绝经前雌激素水平低可增加未来患糖尿病的风险

2016-12-21 MedSci MedSci原创

本研究旨在研究绝经过渡期雌二醇与促卵泡激素水平的变化和糖尿病发生之间关联。研究随访了1047名基线年龄在42-52岁的绝经前妇女,均经历自然绝经。糖尿病的标准取决于空腹血糖水平,药物使用和内科医生诊断报告。使用用Cox比例风险回归评价糖尿病发生和激素变化率三大组成截距(绝经前水平)和两个分段斜率分别代表早期和晚期过渡期的变化。在15年的随访期间,132名女性发展为糖尿病。校正潜在混杂因素后,较高的

本研究旨在研究绝经过渡期雌二醇与促卵泡激素水平的变化和糖尿病发生之间关联。

研究随访了1047名基线年龄在42-52岁的绝经前妇女,均经历自然绝经。糖尿病的标准取决于空腹血糖水平,药物使用和内科医生诊断报告。使用用Cox比例风险回归评价糖尿病发生和激素变化率三大组成截距(绝经前水平)和两个分段斜率分别代表早期和晚期过渡期的变化。

在15年的随访期间,132名女性发展为糖尿病。校正潜在混杂因素后,较高的雌二醇截距,而不是其变化率,与糖尿病的发病风险显著降低相关[四分位间距增加的危害比(75.2 pmol/L)0.53,95%CI 0.27–1.06]。促卵泡激素,仅在过渡早期增长率较高,与糖尿病的发病风险显著降低相关[四分位间距增加的危害比(5.9 IU/L/年)0.31,95%CI 0.10–0.94]。

总而言之,该研究发现,绝经前雌二醇水平较低和过渡早期促卵泡激素变化率较低会增加糖尿病的发生风险。鉴于肥胖在糖尿病发病风险以及绝经过渡期雌二醇和促卵泡激素的水平和变化中发挥着重要的作用,因此中年早期控制体重对阻止糖尿病进一步发展具有重要作用。

原始出处:

Park SK, et al. Association between changes in oestradiol and follicle-stimulating hormone levels during the menopausal transition and risk of diabetes. Diabet Med. 2016.


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    2016-12-22 ylzr123

    绝经前雌二醇水平较低和过渡早期促卵泡激素变化率较低会增加糖尿病的发生风险。

    0

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    2016-12-22 SAd

    糖尿病的影响

    0

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CRISPR–Cas9工具使得科学家们能够几乎随意地改变基因组。人们称赞它比以往的技术明显更简单、更廉价及更通用,CRISPR–Cas9在全球各地的实验室中大放光彩,已发现了一些医学和基础研究的新应用。但CRISPR–Cas9有其局限性。CRISPR–Cas9工具使得科学家们能够几乎随意地改变基因组。人们称赞它比以往的技术明显更简单、更廉价及更通用,CRISPR–Cas9在全球各地的实验室中大放光