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Am J Transl Res：低剂量尼古丁降低了骨折愈合过程中小鼠骨髓间充质干细胞的归巢能力

2019-04-27 不详 网络

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接触烟草中的尼古丁和其他化合物会影响伤口和骨折的愈合。本研究检测了亚毒性浓度的低剂量尼古丁暴露对骨髓干细胞（BMSCs）体外增殖，分化和迁移的影响以及它们在C57BL / 6小鼠中归巢到骨折部位的影响。在用或不用尼古丁（1μM至1mM）处理的细胞中研究BMSC。不同浓度的尼古丁对BMSCs的生长调节和骨骼分化有不同的影响。CCK8试验显示，在1mM的高尼古丁浓度下细胞活力明显增加，而在相同浓度下茜

接触烟草中的尼古丁和其他化合物会影响伤口和骨折的愈合。本研究检测了亚毒性浓度的低剂量尼古丁暴露对骨髓干细胞（BMSCs）体外增殖，分化和迁移的影响以及它们在C57BL / 6小鼠中归巢到骨折部位的影响。

在用或不用尼古丁（1μM至1mM）处理的细胞中研究BMSC。不同浓度的尼古丁对BMSCs的生长调节和骨骼分化有不同的影响。CCK8试验显示，在1mM的高尼古丁浓度下细胞活力明显增加，而在相同浓度下茜素红的钙结节染色减少。体外划痕试验，Transwell试验和体内BMSCs归巢试验显示在10μM至1mM尼古丁试验中对BMSC迁移的负面影响。实时PCR分析揭示了SDF-1，CXCR4和CXCR7的下调，它们是强效趋化信号系统的成员。Western印迹分析表明尼古丁处理的成骨细胞（1μM至100μM）表达的periostin表达水平下调。微CT结果显示，尼古丁延缓了小鼠的骨折愈合。

总之，该研究结果表明，接触低剂量尼古丁浓度可能通过抑制BMSCs的迁移和归巢来影响骨形成，这可能是吸烟患者骨愈合延迟的重要危险因素。

原始出处：

Jing Zhang, Qilong Wan, et al., Low-dose nicotine reduces the homing ability of murine BMSCs during fracture healing. Am J Transl Res. 2018; 10(9): 2796–2809.

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    2020-03-23 ms3025846204744509

    #Transl#

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    2019-07-05 h.y200607_23674418

    #间充质干细#

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    2019-09-29 ying_wu

    #骨髓间充质干细胞#

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    2019-10-21 HinsMax

    #骨折愈合#

    0

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    2019-06-23 bsmagic9140

    #TRA#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2067435, encodeId=ce2c206e43541, content=<a href='/topic/show?id=d0841e75535' target=_blank style='color:#2F92EE;'>#Transl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17755, encryptionId=d0841e75535, topicName=Transl)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Mon Mar 23 22:09:00 CST 2020, time=2020-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815486, encodeId=608e1815486aa, content=<a href='/topic/show?id=ae359e231d4' target=_blank style='color:#2F92EE;'>#间充质干细#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97231, encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Fri Jul 05 05:09:00 CST 2019, time=2019-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1705517, encodeId=6a291e05517cb, content=<a href='/topic/show?id=31f9102015b3' target=_blank style='color:#2F92EE;'>#骨髓间充质干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102015, encryptionId=31f9102015b3, topicName=骨髓间充质干细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=723a30986413, createdName=ying_wu, createdTime=Sun Sep 29 15:09:00 CST 2019, time=2019-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1689131, encodeId=c69716891316d, content=<a href='/topic/show?id=b8ac10168e8b' target=_blank style='color:#2F92EE;'>#骨折愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101687, encryptionId=b8ac10168e8b, topicName=骨折愈合)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ce4c28733108, createdName=HinsMax, createdTime=Mon Oct 21 23:09:00 CST 2019, time=2019-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1657164, encodeId=550a165e16463, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Sun Jun 23 05:09:00 CST 2019, time=2019-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480544, encodeId=146614805447b, content=<a href='/topic/show?id=647d2615939' target=_blank style='color:#2F92EE;'>#低剂量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26159, encryptionId=647d2615939, topicName=低剂量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97b17641126, createdName=ms1292405679162969, createdTime=Mon Apr 29 06:09:00 CST 2019, time=2019-04-29, status=1, ipAttribution=)]
    2019-04-29 ms1292405679162969

    #低剂量#

    0