Gastroenterology:饮食与克罗恩病风险

2020-10-19 MedSci原创 MedSci原创

高炎症风险饮食增加参与者克罗恩病风险,但与溃疡性结肠炎风险无关

抑制炎症是饮食调节用于预防炎症性肠病发病的潜在机制。近日研究人员分析了来自3个大型前瞻性队列的数据,以确定饮食中潜在的炎症因素对克罗恩病(CD)和溃疡性结肠炎(UC)风险的影响。

研究人员收集了护士健康研究(1984-2014年)、护士健康研究II(1991-2015年)和卫生专业人员随访研究(1986-2012年)的相关数据,包含166903名女性和41931名男性参与者。根据食物频率问卷获得的18个食物组的加权总分,计算经验膳食炎症模式(EDIP)评分。饮食中潜在的炎症因素定义为可导致三种血浆炎症生物标志物增加的饮食模式,包括白细胞介素-6、C反应蛋白和肿瘤坏死因子-α受体2(肿瘤坏死因子-αR2),其中导致EDIP评分增加的食物包括加工肉类(如热狗,培根),红肉,动物肝脏,部分海产品(金枪鱼罐头、虾、裹面包屑的鱼类或龙虾)等,可降低EDIP评分的食物包括淡啤酒,红酒,茶,咖啡,黄色蔬菜(南瓜、红薯、胡萝卜),绿色蔬菜(菠菜、卷心莴苣、生菜)和果汁等。

在4949938随访年中,共有328例CD和428例UC患者。诊断IBD的中位年龄为55岁。与累积平均EDIP评分最低四分之一的参与者相比,处于最高四分之一(最高的饮食致炎症风险)参与者患CD的风险高51%(HR :1.51)。与EDIP评分持续较低的参与者(2个时间点,相隔8年)相比,那些炎症风险不断增加(HR:2.05)或持续食用促炎饮食参与者(HR:1.77)患CD的风险更大。饮食中的炎症风险与UC发生无关。

研究认为,高炎症风险饮食增加参与者克罗恩病风险,但与溃疡性结肠炎风险无关。

原始出处:

Chun-Han Lo et al. Dietary Inflammatory Potential and Risk of Crohn's Disease and Ulcerative Colitis.Gastroenterology. SEPTEMBER 01,2020.

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    2021-05-01 许安
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createdBy=7c585423313, createdName=ms3000000833147554, createdTime=Tue Oct 20 20:04:40 CST 2020, time=2020-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893348, encodeId=87af89334811, content=饮食太重要了, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220301/6252e946e5ef413b86dc0f7d1f73b6db/9a7e8c88a38e487b8da4968a67bbd261.png, createdBy=b9f692910, createdName=rayms, createdTime=Tue Oct 20 17:53:07 CST 2020, time=2020-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893179, encodeId=c1b38931e96c, content=很深入的了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201019/899a0c7fe42f4c4db20bf001246e4163/f5fafb49bb454fafb1b489a455453ae5.jpg, createdBy=30d05427438, createdName=ms9000001266392671, createdTime=Mon Oct 19 23:09:30 CST 2020, time=2020-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893178, encodeId=e63c8931e81b, content=真的很好 很深入的了解了, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201019/899a0c7fe42f4c4db20bf001246e4163/f5fafb49bb454fafb1b489a455453ae5.jpg, createdBy=30d05427438, createdName=ms9000001266392671, createdTime=Mon Oct 19 23:09:08 CST 2020, time=2020-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893137, encodeId=60d589313ec1, content=学, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8db85079905, createdName=145aeb72m95暂无昵称, createdTime=Mon Oct 19 19:16:11 CST 2020, time=2020-10-19, status=1, ipAttribution=)]
    2020-11-30 ms3000000290798030

    👍

    0

  5. 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  6. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8db85079905, createdName=145aeb72m95暂无昵称, createdTime=Mon Oct 19 19:16:11 CST 2020, time=2020-10-19, status=1, ipAttribution=)]
    2020-10-20 ms3000000833147554

    为何与克罗恩有关,溃结无影响

    0

  7. 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createdBy=7c585423313, createdName=ms3000000833147554, createdTime=Tue Oct 20 20:04:40 CST 2020, time=2020-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893348, encodeId=87af89334811, content=饮食太重要了, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220301/6252e946e5ef413b86dc0f7d1f73b6db/9a7e8c88a38e487b8da4968a67bbd261.png, createdBy=b9f692910, createdName=rayms, createdTime=Tue Oct 20 17:53:07 CST 2020, time=2020-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893179, encodeId=c1b38931e96c, content=很深入的了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8db85079905, createdName=145aeb72m95暂无昵称, createdTime=Mon Oct 19 19:16:11 CST 2020, time=2020-10-19, status=1, ipAttribution=)]
    2020-10-20 rayms

    饮食太重要了

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2073144, encodeId=92dc20e314416, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Sat May 01 17:08:06 CST 2021, time=2021-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712585, encodeId=19ad1e125853e, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, 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createdName=ms3000000290798030, createdTime=Mon Nov 30 15:28:33 CST 2020, time=2020-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1505115, encodeId=0832150511588, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Wed Oct 21 10:08:06 CST 2020, time=2020-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893371, encodeId=f5be8933e15a, content=为何与克罗恩有关,溃结无影响, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7c585423313, createdName=ms3000000833147554, createdTime=Tue Oct 20 20:04:40 CST 2020, time=2020-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893348, encodeId=87af89334811, content=饮食太重要了, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220301/6252e946e5ef413b86dc0f7d1f73b6db/9a7e8c88a38e487b8da4968a67bbd261.png, createdBy=b9f692910, createdName=rayms, createdTime=Tue Oct 20 17:53:07 CST 2020, time=2020-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893179, encodeId=c1b38931e96c, content=很深入的了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201019/899a0c7fe42f4c4db20bf001246e4163/f5fafb49bb454fafb1b489a455453ae5.jpg, createdBy=30d05427438, createdName=ms9000001266392671, createdTime=Mon Oct 19 23:09:30 CST 2020, time=2020-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893178, encodeId=e63c8931e81b, content=真的很好 很深入的了解了, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201019/899a0c7fe42f4c4db20bf001246e4163/f5fafb49bb454fafb1b489a455453ae5.jpg, createdBy=30d05427438, createdName=ms9000001266392671, createdTime=Mon Oct 19 23:09:08 CST 2020, time=2020-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893137, encodeId=60d589313ec1, content=学, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8db85079905, createdName=145aeb72m95暂无昵称, createdTime=Mon Oct 19 19:16:11 CST 2020, time=2020-10-19, status=1, ipAttribution=)]
    2020-10-19 ms9000001266392671

    很深入的了解

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=2073144, encodeId=92dc20e314416, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Sat May 01 17:08:06 CST 2021, time=2021-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712585, encodeId=19ad1e125853e, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sun May 23 23:08:06 CST 2021, time=2021-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2065186, encodeId=65ec2065186b5, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Thu Oct 29 05:08:06 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=903560, encodeId=7d1490356063, content=👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ed25427370, createdName=ms3000000290798030, createdTime=Mon Nov 30 15:28:33 CST 2020, time=2020-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1505115, encodeId=0832150511588, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Wed Oct 21 10:08:06 CST 2020, time=2020-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893371, encodeId=f5be8933e15a, content=为何与克罗恩有关,溃结无影响, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7c585423313, createdName=ms3000000833147554, createdTime=Tue Oct 20 20:04:40 CST 2020, time=2020-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893348, encodeId=87af89334811, content=饮食太重要了, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220301/6252e946e5ef413b86dc0f7d1f73b6db/9a7e8c88a38e487b8da4968a67bbd261.png, createdBy=b9f692910, createdName=rayms, createdTime=Tue Oct 20 17:53:07 CST 2020, time=2020-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893179, encodeId=c1b38931e96c, content=很深入的了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201019/899a0c7fe42f4c4db20bf001246e4163/f5fafb49bb454fafb1b489a455453ae5.jpg, createdBy=30d05427438, createdName=ms9000001266392671, createdTime=Mon Oct 19 23:09:30 CST 2020, time=2020-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893178, encodeId=e63c8931e81b, content=真的很好 很深入的了解了, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201019/899a0c7fe42f4c4db20bf001246e4163/f5fafb49bb454fafb1b489a455453ae5.jpg, createdBy=30d05427438, createdName=ms9000001266392671, createdTime=Mon Oct 19 23:09:08 CST 2020, time=2020-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893137, encodeId=60d589313ec1, content=学, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8db85079905, createdName=145aeb72m95暂无昵称, createdTime=Mon Oct 19 19:16:11 CST 2020, time=2020-10-19, status=1, ipAttribution=)]
    2020-10-19 ms9000001266392671

    真的很好 很深入的了解了

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=2073144, encodeId=92dc20e314416, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Sat May 01 17:08:06 CST 2021, time=2021-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712585, encodeId=19ad1e125853e, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sun May 23 23:08:06 CST 2021, time=2021-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2065186, encodeId=65ec2065186b5, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Thu Oct 29 05:08:06 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=903560, encodeId=7d1490356063, content=👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ed25427370, createdName=ms3000000290798030, createdTime=Mon Nov 30 15:28:33 CST 2020, time=2020-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1505115, encodeId=0832150511588, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Wed Oct 21 10:08:06 CST 2020, time=2020-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893371, encodeId=f5be8933e15a, content=为何与克罗恩有关,溃结无影响, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7c585423313, createdName=ms3000000833147554, createdTime=Tue Oct 20 20:04:40 CST 2020, time=2020-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893348, encodeId=87af89334811, content=饮食太重要了, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220301/6252e946e5ef413b86dc0f7d1f73b6db/9a7e8c88a38e487b8da4968a67bbd261.png, createdBy=b9f692910, createdName=rayms, createdTime=Tue Oct 20 17:53:07 CST 2020, time=2020-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893179, encodeId=c1b38931e96c, content=很深入的了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201019/899a0c7fe42f4c4db20bf001246e4163/f5fafb49bb454fafb1b489a455453ae5.jpg, createdBy=30d05427438, createdName=ms9000001266392671, createdTime=Mon Oct 19 23:09:30 CST 2020, time=2020-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893178, encodeId=e63c8931e81b, content=真的很好 很深入的了解了, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201019/899a0c7fe42f4c4db20bf001246e4163/f5fafb49bb454fafb1b489a455453ae5.jpg, createdBy=30d05427438, createdName=ms9000001266392671, createdTime=Mon Oct 19 23:09:08 CST 2020, time=2020-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893137, encodeId=60d589313ec1, content=学, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8db85079905, createdName=145aeb72m95暂无昵称, createdTime=Mon Oct 19 19:16:11 CST 2020, time=2020-10-19, status=1, ipAttribution=)]
    2020-10-19 145aeb72m95暂无昵称

    0

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