Clinica Chimica Acta:补充维生素D对维生素D缺乏的慢性荨麻疹患者的临床结果和生化指标的影响

2020-05-12 MedSci原创 MedSci原创

慢性荨麻疹(CU)是一种会逐步令人衰弱的炎症性皮肤病。先前的研究表明,慢性荨麻疹患者会出现维生素D浓度降低,而补充维生素D治疗CU中的潜在有益作用的报道较少。我们评估了维生素D缺乏的患者补充维生素D对

慢性荨麻疹(CU)是一种会逐步令人衰弱的炎症性皮肤病。先前的研究表明,慢性荨麻疹患者会出现维生素D浓度降低,而补充维生素D治疗CU中的潜在有益作用的报道较少。我们评估了维生素D缺乏的患者补充维生素D对临床结果和炎症标志物的影响。

这项随机对照试验涉及120名缺乏维生素d的CU患者。研究人员评估所有病例的荨麻疹活动度评分(UAS7)和自体血浆皮肤试验(APST)状态。CU患者每两周补充维生素D一次,剂量为60,000 IU,为期12周,安慰剂组的患者接受匹配的安慰剂。在基线和12周后从所有研究对象中抽取5毫升血液用于评估炎症标志物。

研究人员观察到,与安慰剂组相比,维生素D组12周后UAS7评分显著降低。还注意到维生素D处理组炎症细胞因子显著减少。

研究表明,在维生素D缺乏的患者中补充维生素D可以显著降低疾病的严重程度,这可能是通过减少全身炎症来调节的。

原始出处:

Archana Mony,Laxmisha Chandrashekar,Effect of vitamin D supplementation on clinical outcome and biochemical profile in South Indian population with vitamin D-deficient chronic urticarial – A randomized double-blind placebo controlled trial

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    2021-11-20 ms7000000534628110

    学习了

    0

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    2021-04-24 ms7000001917513826

    0

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    2020-08-18 lovetcm

    #维生素D#缺乏的患者中补充#维生素#D可以显著降低#慢性荨麻疹#疾病的严重程度,但是也会有很多研究结果是阴性的。这也间接表明维生素D与免疫调控可能有关

    0

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    2020-05-13 windight
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    2020-05-14 zhaojie88