NEJM:HPV疫苗接种与宫颈癌风险

2020-10-01 MedSci原创 MedSci原创

在10至30岁的女孩和妇女中,四价HPV疫苗接种可大大降低浸润性宫颈癌的风险。

已有研究表明四价人乳头瘤病毒(HPV)疫苗在预防高级宫颈病变中的疗效。但是,缺乏四价HPV疫苗接种与随后的浸润性宫颈癌风险之间关系的数据。

近日,顶级医学期刊NEJM上发表了一篇研究文章,研究人员使用了瑞典全国人口统计和健康状况登记处,随访了2006年至2017年期间年龄在10至30岁之间的1672983名女孩和妇女。研究人员评估了HPV疫苗接种与浸润性宫颈癌风险之间的关联,从而调整了随访年龄、年份、居住县和父母特征,包括受教育程度、家庭收入、母亲出生国家和孕产妇疾病史。

在研究期间,研究人员随访了女孩和妇女31岁是否患有宫颈癌。在接受四价HPV疫苗接种的19名妇女和未接受疫苗的538名妇女中诊断出宫颈癌。接种疫苗的妇女中,宫颈癌的累积发病率为每十万人中47人,未接种的妇女中每十万人中94人。调整随访年龄后,将接种人群与未接种人群进行比较宫颈癌的发生率比为0.51(95%置信区间[CI]为0.32至0.82)。在对其他协变量进行额外调整后,宫颈癌发生率比为0.37(95%CI为0.21至0.57)。在对所有协变量进行校正之后,在17岁之前接种疫苗的女性中,发生率比为0.12(95%CI为0.00至0.34),而在年龄在17至30岁期间接种疫苗的女性中为0.47(95%CI为0.27至0.75)。

由此可见,在10至30岁的女孩和妇女中,四价HPV疫苗接种可大大降低浸润性宫颈癌的风险。

原始出处:

Jiayao Lei,et al.HPV Vaccination and the Risk of Invasive Cervical Cancer.NEJM.2020.https://www.nejm.org/doi/full/10.1056/NEJMoa1917338

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    10-30岁打九价如何呢

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1946282, encodeId=2d49194628217, content=<a href='/topic/show?id=0e1c9083cc' target=_blank style='color:#2F92EE;'>#HPV疫苗接种#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9083, encryptionId=0e1c9083cc, topicName=HPV疫苗接种)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=606c2500035, createdName=ms3153534357578991, createdTime=Mon Mar 08 14:03:03 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061966, encodeId=3d0020619664a, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Thu Jun 17 16:03:03 CST 2021, time=2021-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896751, encodeId=49c1896e518d, content=10-30岁打九价如何呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201021/91b58accde114474abf3be8c8b87a1ae/34252556a07149988798e8fcfaa28eb3.jpg, createdBy=3e652197923, createdName=pazilia, createdTime=Wed Nov 04 01:38:58 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2069717, encodeId=052e2069e1749, content=<a href='/topic/show?id=045f4631511' target=_blank style='color:#2F92EE;'>#宫颈癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46315, encryptionId=045f4631511, topicName=宫颈癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f503121, createdName=zjubiostat, createdTime=Sun Apr 04 04:03:03 CST 2021, time=2021-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257895, encodeId=d98a125e8956f, content=<a href='/topic/show?id=f538e0501e9' target=_blank style='color:#2F92EE;'>#疫苗接种#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70501, encryptionId=f538e0501e9, topicName=疫苗接种)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c0050, createdName=lishiwen, createdTime=Sat Oct 03 11:03:03 CST 2020, time=2020-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1408245, encodeId=b41e1408245d5, content=<a href='/topic/show?id=92194628826' target=_blank style='color:#2F92EE;'>#宫颈#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46288, encryptionId=92194628826, topicName=宫颈)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11102737131, createdName=一闲, createdTime=Sat Oct 03 11:03:03 CST 2020, time=2020-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889643, encodeId=b32e8896438d, content=统计方法, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b972455532, createdName=1240394fm61暂无昵称, createdTime=Fri Oct 02 06:24:17 CST 2020, time=2020-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889635, encodeId=fb81889635d6, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2018/12/21/4f44faf1a314b0625d056eac8fc47900.jpg, createdBy=8b5e2207636, createdName=丶raito, createdTime=Fri Oct 02 00:47:56 CST 2020, time=2020-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035437, encodeId=044a103543e9a, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Oct 01 23:03:03 CST 2020, time=2020-10-01, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1946282, encodeId=2d49194628217, content=<a href='/topic/show?id=0e1c9083cc' target=_blank style='color:#2F92EE;'>#HPV疫苗接种#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9083, encryptionId=0e1c9083cc, topicName=HPV疫苗接种)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=606c2500035, createdName=ms3153534357578991, createdTime=Mon Mar 08 14:03:03 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061966, encodeId=3d0020619664a, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Thu Jun 17 16:03:03 CST 2021, time=2021-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896751, encodeId=49c1896e518d, content=10-30岁打九价如何呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201021/91b58accde114474abf3be8c8b87a1ae/34252556a07149988798e8fcfaa28eb3.jpg, createdBy=3e652197923, createdName=pazilia, createdTime=Wed Nov 04 01:38:58 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2069717, encodeId=052e2069e1749, content=<a href='/topic/show?id=045f4631511' target=_blank style='color:#2F92EE;'>#宫颈癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46315, encryptionId=045f4631511, topicName=宫颈癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f503121, createdName=zjubiostat, createdTime=Sun Apr 04 04:03:03 CST 2021, time=2021-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257895, encodeId=d98a125e8956f, content=<a href='/topic/show?id=f538e0501e9' target=_blank style='color:#2F92EE;'>#疫苗接种#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70501, encryptionId=f538e0501e9, topicName=疫苗接种)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c0050, createdName=lishiwen, createdTime=Sat Oct 03 11:03:03 CST 2020, time=2020-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1408245, encodeId=b41e1408245d5, content=<a href='/topic/show?id=92194628826' target=_blank style='color:#2F92EE;'>#宫颈#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46288, encryptionId=92194628826, topicName=宫颈)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11102737131, createdName=一闲, createdTime=Sat Oct 03 11:03:03 CST 2020, time=2020-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889643, encodeId=b32e8896438d, content=统计方法, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b972455532, createdName=1240394fm61暂无昵称, createdTime=Fri Oct 02 06:24:17 CST 2020, time=2020-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889635, encodeId=fb81889635d6, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2018/12/21/4f44faf1a314b0625d056eac8fc47900.jpg, createdBy=8b5e2207636, createdName=丶raito, createdTime=Fri Oct 02 00:47:56 CST 2020, time=2020-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035437, encodeId=044a103543e9a, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Oct 01 23:03:03 CST 2020, time=2020-10-01, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1946282, encodeId=2d49194628217, content=<a href='/topic/show?id=0e1c9083cc' target=_blank style='color:#2F92EE;'>#HPV疫苗接种#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9083, encryptionId=0e1c9083cc, topicName=HPV疫苗接种)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=606c2500035, createdName=ms3153534357578991, createdTime=Mon Mar 08 14:03:03 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061966, encodeId=3d0020619664a, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Thu Jun 17 16:03:03 CST 2021, time=2021-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896751, encodeId=49c1896e518d, content=10-30岁打九价如何呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201021/91b58accde114474abf3be8c8b87a1ae/34252556a07149988798e8fcfaa28eb3.jpg, createdBy=3e652197923, createdName=pazilia, createdTime=Wed Nov 04 01:38:58 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2069717, encodeId=052e2069e1749, content=<a href='/topic/show?id=045f4631511' target=_blank style='color:#2F92EE;'>#宫颈癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46315, encryptionId=045f4631511, topicName=宫颈癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f503121, createdName=zjubiostat, createdTime=Sun Apr 04 04:03:03 CST 2021, time=2021-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257895, encodeId=d98a125e8956f, content=<a href='/topic/show?id=f538e0501e9' target=_blank style='color:#2F92EE;'>#疫苗接种#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70501, encryptionId=f538e0501e9, topicName=疫苗接种)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c0050, createdName=lishiwen, createdTime=Sat Oct 03 11:03:03 CST 2020, time=2020-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1408245, encodeId=b41e1408245d5, content=<a href='/topic/show?id=92194628826' target=_blank style='color:#2F92EE;'>#宫颈#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46288, encryptionId=92194628826, topicName=宫颈)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11102737131, createdName=一闲, createdTime=Sat Oct 03 11:03:03 CST 2020, time=2020-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889643, encodeId=b32e8896438d, content=统计方法, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b972455532, createdName=1240394fm61暂无昵称, createdTime=Fri Oct 02 06:24:17 CST 2020, time=2020-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889635, encodeId=fb81889635d6, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2018/12/21/4f44faf1a314b0625d056eac8fc47900.jpg, createdBy=8b5e2207636, createdName=丶raito, createdTime=Fri Oct 02 00:47:56 CST 2020, time=2020-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035437, encodeId=044a103543e9a, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Oct 01 23:03:03 CST 2020, time=2020-10-01, status=1, ipAttribution=)]
    2020-10-03 一闲
  7. [GetPortalCommentsPageByObjectIdResponse(id=1946282, encodeId=2d49194628217, content=<a href='/topic/show?id=0e1c9083cc' target=_blank style='color:#2F92EE;'>#HPV疫苗接种#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9083, encryptionId=0e1c9083cc, topicName=HPV疫苗接种)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=606c2500035, createdName=ms3153534357578991, createdTime=Mon Mar 08 14:03:03 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061966, encodeId=3d0020619664a, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Thu Jun 17 16:03:03 CST 2021, time=2021-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896751, encodeId=49c1896e518d, content=10-30岁打九价如何呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201021/91b58accde114474abf3be8c8b87a1ae/34252556a07149988798e8fcfaa28eb3.jpg, createdBy=3e652197923, createdName=pazilia, createdTime=Wed Nov 04 01:38:58 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2069717, encodeId=052e2069e1749, content=<a href='/topic/show?id=045f4631511' target=_blank style='color:#2F92EE;'>#宫颈癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46315, encryptionId=045f4631511, topicName=宫颈癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f503121, createdName=zjubiostat, createdTime=Sun Apr 04 04:03:03 CST 2021, time=2021-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257895, encodeId=d98a125e8956f, content=<a href='/topic/show?id=f538e0501e9' target=_blank style='color:#2F92EE;'>#疫苗接种#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70501, encryptionId=f538e0501e9, topicName=疫苗接种)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c0050, createdName=lishiwen, createdTime=Sat Oct 03 11:03:03 CST 2020, time=2020-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1408245, encodeId=b41e1408245d5, content=<a href='/topic/show?id=92194628826' target=_blank style='color:#2F92EE;'>#宫颈#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46288, encryptionId=92194628826, topicName=宫颈)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11102737131, createdName=一闲, createdTime=Sat Oct 03 11:03:03 CST 2020, time=2020-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889643, encodeId=b32e8896438d, content=统计方法, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b972455532, createdName=1240394fm61暂无昵称, createdTime=Fri Oct 02 06:24:17 CST 2020, time=2020-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889635, encodeId=fb81889635d6, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2018/12/21/4f44faf1a314b0625d056eac8fc47900.jpg, createdBy=8b5e2207636, createdName=丶raito, createdTime=Fri Oct 02 00:47:56 CST 2020, time=2020-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035437, encodeId=044a103543e9a, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Oct 01 23:03:03 CST 2020, time=2020-10-01, status=1, ipAttribution=)]
    2020-10-02 1240394fm61暂无昵称

    统计方法

    0

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    2020-10-02 丶raito

    学习

    0

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    2020-10-01 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

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