Radiology:四氧嘧啶诱导糖尿病兔子椎体微血管渗透性及脂肪分数定量评价

2018-01-30 shaosai MedSci原创

本研究旨在利用定量对比增强(DCE)磁共振(MR)成像及IEDAL IQ序列验证糖尿病兔子模型腰椎椎体骨髓渗透性与腰髓脂肪组织的关系,并将结果发表在Radiology上。

本研究旨在利用定量对比增强(DCE)磁共振(MR)成像及IEDAL IQ序列验证糖尿病兔子模型腰椎椎体骨髓渗透性与腰髓脂肪组织的关系,并将结果发表在Radiology上。

本研究共纳入了20只兔子并分为糖尿病组(n = 10)和对照组(n = 10)。所有兔子进行矢状位腰椎MR扫描,扫描时间节点为四氧嘧啶诱导后0、 4、 8、 12、 16周。利用线性混合效应模型分析16个周内脂肪分数(FF)和渗透性参数变化。利用Spearman 相关系数分析DCE MR成像参数与FF及微血管密度(MVD)的相关性。

结果为,注射12周后,转移常数(K trans)和比率常数(K ep)显着性增加,而血浆容积分数(V p)显着降低。在糖尿病组,16周后,血管外-细胞外空间体积明显减少。MVD与K trans 、K ep 负性相关,而与V e 、V p正相关;FF与K trans、K ep 正相关,而与V e、V p 负相关(P < .05 for all)。

本研究表明,DCE MR成像和IDEAL IQ序列可用来对椎体微血管渗透性和椎体脂肪沉积进行定量评价,相应改变与脂肪沉积有关。

原始出处:


10.1148/radiol.2017170760

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    2018-02-04 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

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    2018-02-02 flysky120

    学习一下知识了

    0

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createdName=1e1c07bdm01(暂无匿称), createdTime=Thu Feb 01 03:51:57 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283865, encodeId=406e283865df, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Wed Jan 31 14:53:03 CST 2018, time=2018-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283786, encodeId=67ee283e8679, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Jan 31 08:41:51 CST 2018, time=2018-01-31, status=1, ipAttribution=)]
    2018-02-02 lou.minghong

    学习谢谢分享

    0

  5. 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createdName=1e1c07bdm01(暂无匿称), createdTime=Thu Feb 01 03:51:57 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283865, encodeId=406e283865df, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Wed Jan 31 14:53:03 CST 2018, time=2018-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283786, encodeId=67ee283e8679, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Jan 31 08:41:51 CST 2018, time=2018-01-31, status=1, ipAttribution=)]
    2018-02-01 huagfeg
  6. 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createdName=1e1c07bdm01(暂无匿称), createdTime=Thu Feb 01 03:51:57 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283865, encodeId=406e283865df, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Wed Jan 31 14:53:03 CST 2018, time=2018-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283786, encodeId=67ee283e8679, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Jan 31 08:41:51 CST 2018, time=2018-01-31, status=1, ipAttribution=)]
    2018-02-01 dingxiaobo
  7. 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createdName=1e1c07bdm01(暂无匿称), createdTime=Thu Feb 01 03:51:57 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283865, encodeId=406e283865df, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Wed Jan 31 14:53:03 CST 2018, time=2018-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283786, encodeId=67ee283e8679, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Jan 31 08:41:51 CST 2018, time=2018-01-31, status=1, ipAttribution=)]
    2018-02-01 mgqwxj
  8. 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  9. 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Jan 31 08:41:51 CST 2018, time=2018-01-31, status=1, ipAttribution=)]
    2018-01-31 sunfeifeiyang

    0

  10. 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    2018-01-31 明月清辉

    谢谢分享.学习了

    0

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