Clin Interv Aging: 相对握力可用作定期监测绝经后妇女炎症、衰老和骨骼肌减少

2022-06-24 影像小生 MedSci原创

相对握力与高hs-CRP水平呈负相关且独立相关,这表明相对握力可能是评估绝经后妇女低级别炎症的有用工具。

炎症标志物和急性期蛋白水平的增加是衰老过程的共同特征。炎症-衰老描述的是一种无明显感染的慢性低度全身老化炎症。炎症-老化的来源包括以下因素:

1)损伤的大分子和细胞随着衰老而积累的自身碎片,

2)口腔或肠道微生物成分产生的有害产物,

3)随着年龄的增长凝血系统的激活增加,

4)细胞衰老是细胞对损伤和应激的一种反应。

此外,绝经后的女性腹腔内脂肪增多,可通过脂肪细胞因子导致慢性低级别炎症最近的研究表明,持续的低级别促炎状态与重要的年龄相关疾病相关,如心血管疾病(CVD)、糖尿病、代谢综合征和几种癌症。因此,早期发现低度炎症对预防这些与年龄相关的疾病很重要。C -反应蛋白(CRP)在肝脏中产生,是应用最广泛的炎症标志物损伤或感染的急性反应可能会增加CRP,但最近的研究也显示,在心血管代谢疾病(如CVD、糖尿病和代谢综合征)存在的情况下,CRP升高伴有慢性低级别炎症反应。慢性炎症在身体机能衰弱和丧失的病理生理过程中起着关键作用,而这与肌少症密切相关。女性在绝经后,肌肉质量和力量的下降会加速。

Clin Interv Aging刊发了韩国延世大学医学院Da-Hye Son等的研究结果,研究了绝经后妇女高敏感C反应蛋白(hs-CRP)和相对握力(HGS)之间的关系。

该横断面研究纳入2015 - 2018年参加韩国国民健康与营养调查(KNHNES)的2171名45岁的绝经后妇女。相对握力分为以下四分位数:Q1,< 0.810(公斤/ BMI);Q2, 0.810-0.968(kg/BMI);Q3, 0.969-1.119(kg/BMI);Q4,>1.119(公斤/ BMI)。高hs-CRP的比值比(ORs)和95%置信区间(95% CIs)(>1.0 mg/L,当前样本的75%)通过多元逻辑回归分析计算相对握力四分位数。

根据相对握力四分位数计算hs-CRP平均值。P值的计算采用方差分析检验。

高hs-CRP率随相对握力四分位数的增加而降低。与最高四分位数相比,在调整了年龄、高血压、糖尿病、血脂异常、教育、家庭收入、体育活动、力量锻炼、吸烟和饮酒后,高hs-CRP的最低相对握力四分位数的OR(95% CI)为3.266(2.227-4.789)。血清hs-CRP水平与相对握力呈独立负相关。

总之,相对握力与高hs-CRP水平呈负相关且独立相关,这表明相对握力可能是评估绝经后妇女低级别炎症的有用工具相对握力易于测量,可作为医生定期监测绝经后妇女炎症、衰老和骨骼肌减少的定量工具。

 

原文出处

Son DH, Song SA, Lee YJ. Association Between C-Reactive Protein and Relative Handgrip Strength in Postmenopausal Korean Women Aged 45–80 Years: A Cross-Sectional Study. Clin Interv Aging. 2022;17:971-978
https://doi.org/10.2147/CIA.S356947.

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    2023-04-10 syscxl
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    2022-06-26 zxxiang

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JAHA:口腔微生物组与绝经后妇女高血压有关

特定的口腔细菌与绝经后妇女的基线血压状态和高血压发生风险相关。需要进行研究以确定这些观察性结果并阐明其机制。