JAHA:阻塞性睡眠呼吸暂停患者睡眠觉醒与高血压的关系

2022-01-03 MedSci原创 MedSci原创

睡眠中反复觉醒与OSA患者的高血压患病率独立相关。

阻塞性睡眠呼吸暂停(OSA)以反复发作的上呼吸道阻塞为特征,是最常见的睡眠呼吸障碍,一般人群中占9%至38%。众所周知,OSA会增加心血管疾病的风险,例如高血压和冠心病。重复唤醒引起的睡眠碎片化是阻塞性睡眠呼吸暂停(OSA)的标志。

在基于社区的研究中,睡眠片段化与高血压有关,但尚不清楚这种关联是否在OSA中表现出来。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员旨在探讨睡眠中的频繁觉醒是否会改变OSA与高血压之间的关系。

该研究共纳入了10102名OSA患者和1614名原发性打鼾者。高血压是根据直接测量血压或由医生诊断来定义的。自发性、呼吸性和运动性觉醒是通过多导睡眠图获得的。Logistic回归模型用于估计OSA和原发性打鼾患者的觉醒与高血压患病率之间的关联。

总觉醒指数每增加10个单位,总样本(比值比[OR]为1.08;95%CI为1.03-1.14;P=0.002)和OSA患者(OR为1.10;95%CI为1.04–1.16;P<0.001)患高血压的几率显著增加,但在原发性打鼾组中并不显著。总觉醒指数与总样本(β=0.05和β=0.06;P<0.001)和OSA患者(β=0.05和β=0.06;P<0.01)的收缩压和舒张压显著相关,但在原发性打鼾者则不然。此外,研究人员还注意到有觉醒的呼吸事件比无觉醒的呼吸事件对OSA血压的影响更大。该研究的结局与混杂因素无关,包括呼吸暂停低通气指数和夜间低氧血症。

由此可见,睡眠中反复觉醒与OSA患者的高血压患病率独立相关。

原始出处:

Rong Ren,et al.Association Between Arousals During Sleep and Hypertension Among Patients With Obstructive Sleep Apnea.JAHA.2022.https://www.ahajournals.org/doi/10.1161/JAHA.121.022141

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    2022-03-15 tomyang96
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    2022-11-22 guoyibin
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    2022-01-05 zhaohui6731
  5. [GetPortalCommentsPageByObjectIdResponse(id=1696998, encodeId=ed0e169699871, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Tue Mar 15 21:58:19 CST 2022, time=2022-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1989193, encodeId=7bfa1989193f6, content=<a href='/topic/show?id=246ee29858f' target=_blank style='color:#2F92EE;'>#睡眠呼吸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72985, encryptionId=246ee29858f, topicName=睡眠呼吸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Thu Oct 06 18:58:19 CST 2022, time=2022-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1645373, encodeId=ded016453e33f, content=<a href='/topic/show?id=adfe9090e2b' target=_blank style='color:#2F92EE;'>#觉醒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90907, encryptionId=adfe9090e2b, topicName=觉醒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=36f323200284, createdName=guoyibin, createdTime=Tue Nov 22 15:58:19 CST 2022, time=2022-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268720, encodeId=e2ee1268e2023, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Wed Jan 05 01:58:19 CST 2022, time=2022-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596631, encodeId=50a615966314b, content=<a href='/topic/show?id=70e4396491a' target=_blank style='color:#2F92EE;'>#呼吸暂停#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39649, encryptionId=70e4396491a, topicName=呼吸暂停)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2a518392360, createdName=119337463, createdTime=Wed Jan 05 01:58:19 CST 2022, time=2022-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1180298, encodeId=58811180298ba, content=疫性血小板减少症 (ITP) 和温性自身免疫性, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Tue Jan 04 09:17:09 CST 2022, time=2022-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1180273, encodeId=678d11802e3f8, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/KB0DqQbFzvqeNgWI3mqTZfEBRicSUHpLFicRASePbnLAh7cjqLYJ4QRjCboVcD7kawu6kcfe7PiaLMtwAMQlO6xIg/132, createdBy=4bfd5306331, createdName=一洼菜地, createdTime=Tue Jan 04 08:20:57 CST 2022, time=2022-01-04, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1696998, encodeId=ed0e169699871, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Tue Mar 15 21:58:19 CST 2022, time=2022-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1989193, encodeId=7bfa1989193f6, content=<a href='/topic/show?id=246ee29858f' target=_blank style='color:#2F92EE;'>#睡眠呼吸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72985, encryptionId=246ee29858f, topicName=睡眠呼吸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Thu Oct 06 18:58:19 CST 2022, time=2022-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1645373, encodeId=ded016453e33f, content=<a href='/topic/show?id=adfe9090e2b' target=_blank style='color:#2F92EE;'>#觉醒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90907, encryptionId=adfe9090e2b, topicName=觉醒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=36f323200284, createdName=guoyibin, createdTime=Tue Nov 22 15:58:19 CST 2022, time=2022-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268720, encodeId=e2ee1268e2023, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Wed Jan 05 01:58:19 CST 2022, time=2022-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596631, encodeId=50a615966314b, content=<a href='/topic/show?id=70e4396491a' target=_blank style='color:#2F92EE;'>#呼吸暂停#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39649, encryptionId=70e4396491a, topicName=呼吸暂停)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2a518392360, createdName=119337463, createdTime=Wed Jan 05 01:58:19 CST 2022, time=2022-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1180298, encodeId=58811180298ba, content=疫性血小板减少症 (ITP) 和温性自身免疫性, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Tue Jan 04 09:17:09 CST 2022, time=2022-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1180273, encodeId=678d11802e3f8, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/KB0DqQbFzvqeNgWI3mqTZfEBRicSUHpLFicRASePbnLAh7cjqLYJ4QRjCboVcD7kawu6kcfe7PiaLMtwAMQlO6xIg/132, createdBy=4bfd5306331, createdName=一洼菜地, createdTime=Tue Jan 04 08:20:57 CST 2022, time=2022-01-04, status=1, ipAttribution=)]
    2022-01-04 查查佳佳

    疫性血小板减少症 (ITP) 和温性自身免疫性

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1696998, encodeId=ed0e169699871, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Tue Mar 15 21:58:19 CST 2022, time=2022-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1989193, encodeId=7bfa1989193f6, content=<a href='/topic/show?id=246ee29858f' target=_blank style='color:#2F92EE;'>#睡眠呼吸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72985, encryptionId=246ee29858f, topicName=睡眠呼吸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Thu Oct 06 18:58:19 CST 2022, time=2022-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1645373, encodeId=ded016453e33f, content=<a href='/topic/show?id=adfe9090e2b' target=_blank style='color:#2F92EE;'>#觉醒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90907, encryptionId=adfe9090e2b, topicName=觉醒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=36f323200284, createdName=guoyibin, createdTime=Tue Nov 22 15:58:19 CST 2022, time=2022-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268720, encodeId=e2ee1268e2023, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Wed Jan 05 01:58:19 CST 2022, time=2022-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596631, encodeId=50a615966314b, content=<a href='/topic/show?id=70e4396491a' target=_blank style='color:#2F92EE;'>#呼吸暂停#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39649, encryptionId=70e4396491a, topicName=呼吸暂停)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2a518392360, createdName=119337463, createdTime=Wed Jan 05 01:58:19 CST 2022, time=2022-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1180298, encodeId=58811180298ba, content=疫性血小板减少症 (ITP) 和温性自身免疫性, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Tue Jan 04 09:17:09 CST 2022, time=2022-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1180273, encodeId=678d11802e3f8, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/KB0DqQbFzvqeNgWI3mqTZfEBRicSUHpLFicRASePbnLAh7cjqLYJ4QRjCboVcD7kawu6kcfe7PiaLMtwAMQlO6xIg/132, createdBy=4bfd5306331, createdName=一洼菜地, createdTime=Tue Jan 04 08:20:57 CST 2022, time=2022-01-04, status=1, ipAttribution=)]
    2022-01-04 一洼菜地

    学习

    0

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