Clinica Chimica Acta:在胸膜和腹腔积液的诊断中的混合生物标记

2019-11-23 gladiator MedSci原创

在临床实践中,胸腔积液和腹腔积液非常常见

临床实践中,胸腔积液和腹腔积液非常常见。因此,本研究评估了混合生物标志物在诊断胸膜和/或腹膜主要疾病中的表现。

研究人员对120例患者的胸膜/腹膜液样品进行了CEA(癌胚抗原),VEGF-A血管内皮生长因子A),PD-L1 / B7-H1(程序性死亡配体1),NGAL(中性粒细胞明胶酶- Luminex®的相关脂质运载蛋白),TREM-1(在1型髓样细胞中表达的触发受体)和IFNγγ-干扰素);并采用酶联免疫吸附法测定钙蛋白,酶联脱氨法测定腺苷脱氨酶。

研究结果显示,在恶性积液(ME)诊断中,CEANGAL表现优于VEGF-APD-L1CALPCEA-NGAL具有良好的敏感性(86.6%)和准确性(79.2%)。非结核性感染性渗出液(NTBIE)的敏感性(75.0%)、特异性(62.0%)和准确性(65.0%)高于TREM-1CALP;然而,当相关时,尽管敏感性较好,但特异性显著下降。对于结核性胸腔积液(TPE) IFNy-ADA具有良好的敏感性(100%)、特异性(87.6%)NPV(100%)和准确性(~90%)

研究表明,CEANGALADAIFNy在鉴别METPE时是有用的。然而,对于NTBIE诊断,混合生物标记并没有优于经典参数。

原始出处:

Daniel K. FariaCaroline S. FariaHybrid panel of biomarkers can be useful in the diagnosis of pleural and peritoneal effusions

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    2020-05-22 windight
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    2020-10-03 lifestar
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