NEJM:结核性腹膜炎-病例报道

2018-09-20 xing.T MedSci原创

该患者服用异烟肼、利福平、乙胺丁醇和吡嗪酰胺治疗2个月,然后用异烟肼和利福平治疗4个月,腹水和相关症状消退。

患者为一名24岁的健康男性,因腹胀、腹痛、发热1个月而到急诊就诊。

体格检查发现带液波的凸出腹壁。对腹水的分析显示淋巴细胞为主,蛋白水平较高,与血清中的蛋白质水平相似,腺苷脱氨酶水平为150 U/L(参考范围为8.6-20.5)。结核分枝杆菌的耐酸染色和聚合酶链反应(PCR)检测结果均为阴性。在给予造影剂后进行的计算机断层扫描显示大量腹水、腹膜增厚和多个扩大的肠系膜淋巴结(如图A所示)。



探查性腹腔镜检查显示腹膜和网膜上有许多白色的粟粒状结节(如图B所示)。腹膜组织病理学分析发现含有朗格汉斯巨细胞的干酪性肉芽肿。通过活组织检查获得网膜病变标本,PCR检测结果和组织培养结果均为结核分枝杆菌阳性;人类免疫缺陷病毒感染检测结果为阴性。对结核分枝杆菌的腹水培养敏感性较低,诊断可能需要腹膜活检。

该患者服用异烟肼、利福平、乙胺丁醇和吡嗪酰胺治疗2个月,然后用异烟肼和利福平治疗4个月,腹水和相关症状消退。

原始出处:

Koh Okamoto,et al. Tuberculous Peritonitis.N Engl J Med 2018; https://www.nejm.org/doi/full/10.1056/NEJMicm1713168

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    2019-05-26 2460c931m

    谢谢分享!

    0

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    2019-05-26 2460c931m

    学习学习

    0

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  5. 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Thu Sep 20 08:07:08 CST 2018, time=2018-09-20, status=1, ipAttribution=)]
  6. 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Thu Sep 20 08:07:08 CST 2018, time=2018-09-20, status=1, ipAttribution=)]
  7. 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createdName=zhaojie88, createdTime=Fri Sep 21 22:46:00 CST 2018, time=2018-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1623805, encodeId=aff9162380506, content=<a href='/topic/show?id=16ba8564526' target=_blank style='color:#2F92EE;'>#腹膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85645, encryptionId=16ba8564526, topicName=腹膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=93e220615097, createdName=xuyong530, createdTime=Fri Sep 21 22:46:00 CST 2018, time=2018-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345940, encodeId=15af34594021, content=是一个结核性腹膜炎的病例报道发了新英格兰吗?酷哦~, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7e71713450, createdName=太阳系小猪, createdTime=Fri Sep 21 07:06:22 CST 2018, time=2018-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345778, encodeId=3672345e7840, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/y6Sk2KiaDibWSs0icexcRzKWXKao9dILdyaB6olvWApA1uiaapa4T9XMiaU7hTZA04uj2iavabfdCT5iaO6AYue5qSJ7MzXaAVSqh6j/0, createdBy=08e01983553, createdName=执迷不悔, createdTime=Thu Sep 20 08:11:17 CST 2018, time=2018-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345776, encodeId=9f7e345e7637, content=学习学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Thu Sep 20 08:07:08 CST 2018, time=2018-09-20, status=1, ipAttribution=)]
    2018-09-21 xuyong530
  8. 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    2018-09-21 太阳系小猪

    是一个结核性腹膜炎的病例报道发了新英格兰吗?酷哦~

    0

  9. 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    2018-09-20 执迷不悔

    学习了

    0

  10. 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    2018-09-20 深海的鱼

    学习学习学习学习

    0