BMC:久坐看电视,会让你的冠心病风险飙升

2022-05-30 生物探索 生物探索

如今,久坐已成常态。白天,坐在电脑前面工作八小时;晚上,又是瘫在床上刷手机,不知不觉过去好几个小时。久而久之,久坐不动已成为大多数人的日常。

2022 年 5 月 24 日,BMC Medicine上发表了一项题为“Genetic susceptibility, screen-based sedentary activities and incidence of coronary heart disease”的研究,该研究表明看电视会增加患冠心病(Coronary heart disease,CHD)的风险,且与个人遗传风险无关,但没有证据表明使用电脑与冠心病发病率之间存在关联。与每天看电视超过 4 小时的人相比,如果人们每天看电视的时间少于1小时,那么可以预防11%的冠心病(图1)。
 

图片

1 研究成果(图源:[1]

 
据了解,久坐不动对人体健康有很大负面影响,如罹患冠心病。久坐是指在坐姿、躺姿或者躺姿下进行的任何清醒行为,产生的能量为≤1.5 METs,即在清醒状态时,一周超过5天,一天大于8小时,或持续2小时没有起身活动的低能量消耗行为。久坐行为的定义为基于屏幕前的久坐活动,如使用电脑办公、靠着或躺着看电视、看手机、玩电脑、看书等(图2)。
 

图片

2 常见的久坐行为

 
此项研究旨在探讨冠心病的遗传易感性与观看电视或使用电脑时长对冠心病发病率的影响。剑桥大学研究人员使用了来自英国生物银行(United Kingdom Biobank)数据库,年龄界于40岁至69岁,且未患有冠心病或中风的373026个个体数据。研究人员通过触摸屏问卷对受试者看电视和使用电脑的情况进行调查,在大约12.6年的随访中判定冠心病发病率。
 
研究人员为这些未患有冠心病/中风个体,使用加权多基因风险评分(Polygenic Risk Score,PRS),通过已知与冠心病风险相关的300个单核苷酸多态性中风险变异来评估每个人患冠心病的遗传风险。计算出的连续PRS呈正态分布,具有较高PRS的个体患冠心病的风险最高(图3)。与低遗传易感性人群相比,中高遗传易感性的冠心病风险比分别为 1.43和 2.04。
 

图片

3 不同年龄段遗传风险的每种类别的冠心病累积风险(图源:[1]

在所有年龄段中,每天看电视用时≥4小时的人患冠心病的风险最大(图4)。与这些人相比,每天看2-3小时电视的人患冠心病的风险相对降低 6%,而看电视时间花费≤1小时的人,患冠心病的风险最低,降低16%。

 

图片

4 电视观看与突发冠心病的遗传风险的联合关联(图源:[1] 

与看电视的结果相比,试验并没有发现任何电脑使用类别与任何遗传风险层相关的证据(图5)。这一观察结果证实了现有的证据,即观看电视而非使用电脑与冠心病风险升高之间的联系。研究人员表示,参与者在看电视时可能会出现不健康的零食行为,从而导致看电视的关联性更强。看电视往往会更长时间、更不间断,尤其是在晚餐后,通常导致餐后血糖和血脂水平升高。

 

图片

5 电脑与突发冠心病的遗传风险的联合关联(图源:[1]

 
看电视是冠心病的一个重要风险标志,与遗传易感性无关。冠心病的遗传风险越高,发生冠心病的风险也越高。电视观看时间越短,所有遗传风险阶层的冠心病发病率也会越低,与较高的遗传易感性相关性更强。
 
MRC流行病学部门的Katrien Wijndaele博士表示:“冠心病是过早死亡的最主要原因之一,因此通过改变生活方式来找到帮助人们管理冠心病风险的方法很重要。”
 
世界卫生组织建议减少久坐行为,并需要任何强度的身体活动来保持健康。因为存在各种潜在的混杂因素和测量误差,虽然不能肯定地说久坐会增加患冠心病的风险,但这项工作提出了一种直接的、可测量的方法。

参考资料:

[1]Kim, Y., Yeung, S.L.A., Sharp, S.J. et al. Genetic susceptibility, screen-based sedentary activities and incidence of coronary heart disease. BMC Med 20, 188(2022). https://doi.org/10.1186/s12916-022-02380-7.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1664335, encodeId=a28b16643356d, content=<a href='/topic/show?id=b5c3e2611c5' target=_blank style='color:#2F92EE;'>#看电视#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72611, encryptionId=b5c3e2611c5, topicName=看电视)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=906225741802, createdName=ms9474365431325850, createdTime=Wed Jan 04 04:50:50 CST 2023, time=2023-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1771033, encodeId=c5a81e7103366, content=<a href='/topic/show?id=5572308336a' target=_blank style='color:#2F92EE;'>#冠心病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30833, encryptionId=5572308336a, topicName=冠心病风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfc938196115, createdName=hbwxf, createdTime=Tue Jun 14 09:50:50 CST 2022, time=2022-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1975202, encodeId=31be19e520263, content=<a href='/topic/show?id=f145355379' target=_blank style='color:#2F92EE;'>#BMC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3553, encryptionId=f145355379, topicName=BMC)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Sat Dec 17 15:50:50 CST 2022, time=2022-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1705234, encodeId=76071e052341a, content=<a href='/topic/show?id=6d55e015911' target=_blank style='color:#2F92EE;'>#电视#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70159, encryptionId=6d55e015911, topicName=电视)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a1230951478, createdName=yhj-time, createdTime=Thu Dec 22 16:50:50 CST 2022, time=2022-12-22, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1664335, encodeId=a28b16643356d, content=<a href='/topic/show?id=b5c3e2611c5' target=_blank style='color:#2F92EE;'>#看电视#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72611, encryptionId=b5c3e2611c5, topicName=看电视)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=906225741802, createdName=ms9474365431325850, createdTime=Wed Jan 04 04:50:50 CST 2023, time=2023-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1771033, encodeId=c5a81e7103366, content=<a href='/topic/show?id=5572308336a' target=_blank style='color:#2F92EE;'>#冠心病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30833, encryptionId=5572308336a, topicName=冠心病风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfc938196115, createdName=hbwxf, createdTime=Tue Jun 14 09:50:50 CST 2022, time=2022-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1975202, encodeId=31be19e520263, content=<a href='/topic/show?id=f145355379' target=_blank style='color:#2F92EE;'>#BMC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3553, encryptionId=f145355379, topicName=BMC)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Sat Dec 17 15:50:50 CST 2022, time=2022-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1705234, encodeId=76071e052341a, content=<a href='/topic/show?id=6d55e015911' target=_blank style='color:#2F92EE;'>#电视#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70159, encryptionId=6d55e015911, topicName=电视)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a1230951478, createdName=yhj-time, createdTime=Thu Dec 22 16:50:50 CST 2022, time=2022-12-22, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1664335, encodeId=a28b16643356d, content=<a href='/topic/show?id=b5c3e2611c5' target=_blank style='color:#2F92EE;'>#看电视#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72611, encryptionId=b5c3e2611c5, topicName=看电视)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=906225741802, createdName=ms9474365431325850, createdTime=Wed Jan 04 04:50:50 CST 2023, time=2023-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1771033, encodeId=c5a81e7103366, content=<a href='/topic/show?id=5572308336a' target=_blank style='color:#2F92EE;'>#冠心病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30833, encryptionId=5572308336a, topicName=冠心病风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfc938196115, createdName=hbwxf, createdTime=Tue Jun 14 09:50:50 CST 2022, time=2022-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1975202, encodeId=31be19e520263, content=<a href='/topic/show?id=f145355379' target=_blank style='color:#2F92EE;'>#BMC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3553, encryptionId=f145355379, topicName=BMC)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Sat Dec 17 15:50:50 CST 2022, time=2022-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1705234, encodeId=76071e052341a, content=<a href='/topic/show?id=6d55e015911' target=_blank style='color:#2F92EE;'>#电视#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70159, encryptionId=6d55e015911, topicName=电视)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a1230951478, createdName=yhj-time, createdTime=Thu Dec 22 16:50:50 CST 2022, time=2022-12-22, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1664335, encodeId=a28b16643356d, content=<a href='/topic/show?id=b5c3e2611c5' target=_blank style='color:#2F92EE;'>#看电视#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72611, encryptionId=b5c3e2611c5, topicName=看电视)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=906225741802, createdName=ms9474365431325850, createdTime=Wed Jan 04 04:50:50 CST 2023, time=2023-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1771033, encodeId=c5a81e7103366, content=<a href='/topic/show?id=5572308336a' target=_blank style='color:#2F92EE;'>#冠心病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30833, encryptionId=5572308336a, topicName=冠心病风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfc938196115, createdName=hbwxf, createdTime=Tue Jun 14 09:50:50 CST 2022, time=2022-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1975202, encodeId=31be19e520263, content=<a href='/topic/show?id=f145355379' target=_blank style='color:#2F92EE;'>#BMC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3553, encryptionId=f145355379, topicName=BMC)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Sat Dec 17 15:50:50 CST 2022, time=2022-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1705234, encodeId=76071e052341a, content=<a href='/topic/show?id=6d55e015911' target=_blank style='color:#2F92EE;'>#电视#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70159, encryptionId=6d55e015911, topicName=电视)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a1230951478, createdName=yhj-time, createdTime=Thu Dec 22 16:50:50 CST 2022, time=2022-12-22, status=1, ipAttribution=)]
    2022-12-22 yhj-time

相关资讯

老人耳垂上有折痕是冠心病的标志?

冠心病有哪些前期征兆?

Lancet:地中海 or 低脂饮食,谁更适合心血管疾病的长期二级预防?

作为主要心血管事件的二级预防策略,地中海饮食的心血管保护作用优于低脂饮食

BMJ:14万护士样本研究,每多上5年夜班,患糖尿病风险增加31%!

今天(5月12日)是第111个“国际护士节”,今年我国护士节的主题是“关爱护士队伍,护佑人民健康”。

OCC 2022:张俊峰教授冠脉CT斑块的判断和评估

OCC大会播报。张俊峰教授:冠脉CT斑块的判断和评估。

OCC 2022:赵水平教授:"理想"胆固醇水平的人为何仍患动脉粥样硬化?

上世纪七、八十年代,我国人群胆固醇水平并不是很高,仍然可以看出胆固醇水平与冠心病死亡的关系。