JAMA Netw Open:亚洲超62万人研究显示,秀恩爱不会死得快,但单身会!全因死亡率升高62%!

2022-06-11 MedSci原创 MedSci原创

JAMA Netw Open:亚洲婚姻状况与总死亡率和特定病因死亡率的关联

在全球范围内,结婚率在过去几十年中有所下降。在婚姻状况与死亡率的关系上存在广泛的一致意见。 最近的荟萃分析显示,未婚个体的全因和病因特异性死亡风险高于已婚同龄人。实现社会经济支持和促进健康的行为被认为是促成这些婚姻保护性联系的因素。从生理学上讲,未婚个体的皮质醇水平较高,昼夜皮质醇斜率较平,这与颈动脉粥样硬化风险增加、糖尿病患者血糖控制不佳、代谢综合征、和癌症患者生存期较短有关。

虽然不同社会的婚姻模式不同,但很少有研究报告非西方人群中婚姻与死亡率之间的联系。东亚的婚姻具有鲜明的特征,包括大家庭核心地位的悠久传统,强调家庭血统以稳定婚姻制度,以及牢固的家庭关系,这与较低的死亡风险有关。然而,亚洲队列的先前研究发表了不一致的结果。鉴于亚洲国家非传染性疾病的流行率日益上升,必须了解婚姻状况与死亡率之间的关系在有潜在合并症的人之间是否存在差异。因此,本研究使用来自亚洲队列联盟(ACC)的个体水平数据进行了一项队列研究,涉及100多万名参与者,以确定婚姻状况与总死亡率和病因特异性死亡率的关系。

该队列研究包括1963年至2015年间在亚洲队列联盟中进行的16项前瞻性研究的个体参与者数据。包括具有婚姻和生命状况完整信息的亚洲参与者。使用Cox比例风险模型估计研究特异性风险比(HRs)和95%CI,然后使用随机效应荟萃分析进行汇总。分析于20212月开始,20218月结束。

分析显示,中位随访15.5年期间,623140名研究对象(326397名女性[52.4%]296743名男性[47.6%];平均[SD]年龄,53.7 [10.2]岁;平均[SD]随访时间,15.5 [6.1]年),确了123264例死亡。与已婚者相比,未婚者全因死亡、因脑血管病死亡、因冠心病死亡、因循环系统疾病死亡、因癌症死亡、因呼吸系统疾病死亡、外部原因死亡的风险分别增加15%HR=1.1595%CI1.07-1.24、12%HR=1.1295%CI1.03-1.22、20%HR=1.2095%CI1.09-1.31、17%HR=1.1795%CI1.07-1.28、6%HR=1.0695%CI1.01-1.11、14%HR=1.1495%CI1.05-1.23、19%HR=1.1995%CI1.05-1.34



在未婚者中,单身、分居、离婚、丧偶四类人群的全因死亡风险分别增加62%HR=1.6295% CI1.41-1.86、35%HR=1.3595%CI1.13-1.61、38%HR=1.3895%CI1.13-1.69、9%HR=1.0995%CI1.04-1.13


值得注意的是,与已婚者相比,单身者死于上述6种原因的风险均显著增加,而其他三种未婚状态人群仅因上述2~4个原因死亡的风险增加。

亚组分析显示,在基线健康状况不同的人群中,未婚者的死亡风险均显著高于已婚者,未婚的男士和65岁以下者的死亡风险尤其高。

 

这项针对个体参与者数据的大型汇总队列研究提供了强有力的证据,证明未婚以及属于未婚亚类与总死亡率和特定原因死亡率呈正相关。鉴于已婚和未婚个人之间的死亡率差异,可能需要考虑对有针对性的社会支助服务进行投资。

原文来源:

Leung CY, Huang H, Abe SK, et al. Association of Marital Status With Total and Cause-Specific Mortality in Asia. JAMA Netw Open. 2022;5(5):e2214181. doi:10.1001/jamanetworkopen.2022.14181

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    2022-11-02 feather89
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    2022-06-29 陈文志

    赶快结婚

    0

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    2023-03-26 医者仁心
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    2022-06-12 1de02e83m55(暂无匿称)

    博眼球,跟秀恩爱有什么关系?结婚的都秀恩爱吗?

    0

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    2022-06-11 achengzhao
  7. [GetPortalCommentsPageByObjectIdResponse(id=1729615, encodeId=6f421e2961513, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Nov 02 21:38:30 CST 2022, time=2022-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1229381, encodeId=0f6512293814d, content=赶快结婚, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=57545476725, createdName=陈文志, createdTime=Wed Jun 29 09:23:45 CST 2022, time=2022-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1734515, encodeId=2ae21e3451547, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Sun Mar 26 15:38:30 CST 2023, time=2023-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1225931, encodeId=88a4122593103, content=博眼球,跟秀恩爱有什么关系?结婚的都秀恩爱吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20230114/c4d12c752c4d43f9875da3cf6ff02b08/917993c4e95e474a96a1289001963588.jpg, createdBy=ca951667545, createdName=1de02e83m55(暂无匿称), createdTime=Sun Jun 12 09:35:38 CST 2022, time=2022-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251584, encodeId=640712515841f, content=<a href='/topic/show?id=874529332ba' target=_blank style='color:#2F92EE;'>#全因死亡率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29332, encryptionId=874529332ba, topicName=全因死亡率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=796422, createdName=lvliquan, createdTime=Sat Jun 11 07:38:30 CST 2022, time=2022-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1603922, encodeId=ce1a1603922cf, content=<a href='/topic/show?id=7849363362b' target=_blank style='color:#2F92EE;'>#单身#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36336, encryptionId=7849363362b, topicName=单身)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cc9719117260, createdName=achengzhao, createdTime=Sat Jun 11 07:38:30 CST 2022, time=2022-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1243552, encodeId=e53d1243552a9, content=JAMA上文章都是顶级的,谢谢梅斯及时上新, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿瘤克星, createdTime=Thu Jun 09 19:38:30 CST 2022, time=2022-06-09, status=1, ipAttribution=)]
    2022-06-09 肿瘤克星

    JAMA上文章都是顶级的,谢谢梅斯及时上新

    0

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