Stem cells:骨髓间充质干细胞分泌的微泡可提高造血干细胞的移植效率

2018-10-10 MedSci MedSci原创

白血病、淋巴瘤、重度再生障碍性贫血等患者常采用骨髓移植,骨髓移植的成功与否关键在于移植的造血细胞(HSCs)的有效植入。当供体HSCs的数量和质量是限制因素时,通过体外对HSCs的操作来提高植入性就成了必要。鉴于骨髓间充质干细胞(MSCs)具有造血支持作用,其往常被用作HSCs体外扩增的滋养层。MSCs在体内可形成特异性HSC壁龛,表明MSCs内存在可影响HSC命运的信号机制。Sapana Jal

白血病淋巴瘤、重度再生障碍性贫血等患者常采用骨髓移植,骨髓移植的成功与否关键在于移植的造血细胞(HSCs)的有效植入。当供体HSCs的数量和质量是限制因素时,通过体外对HSCs的操作来提高植入性就成了必要。

鉴于骨髓间充质干细胞(MSCs)具有造血支持作用,其往常被用作HSCs体外扩增的滋养层。MSCs在体内可形成特异性HSC壁龛,表明MSCs内存在可影响HSC命运的信号机制。Sapana Jalnapurkar等研究人员近期发现MSCs的主导信号——AKT信号可影响HSC功能。以一氧化氮供体——硝普钠(SNP)涂皿培养的MSCs,可通过细胞间转移携带编码HSC支持基因的mRNAs的微泡(MVs)显著促进与其共培养的HSCs的植入潜能。

本研究数据表明上述MVs可用作HSC涂层来提高移植效率。现一氧化氮供体和MSCs均已用于临床;其在临床环境中的应用可能相对直接。该方法或许也可应用于再生医学。


原始出处:

Sapana Jalnapurkar,et al. Microvesicles Secreted by Nitric Oxide‐Primed Mesenchymal Stromal Cells Boost the Engraftment Potential of Hematopoietic Stem Cells. Stem cells.October 05,2018.https://doi.org/10.1002/stem.2912

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content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Fri Oct 12 13:17:00 CST 2018, time=2018-10-12, status=1, ipAttribution=)]
    2019-01-27 维他命
  5. 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content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Fri Oct 12 13:17:00 CST 2018, time=2018-10-12, status=1, ipAttribution=)]
  6. 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encodeId=16173491e426, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Sat Oct 13 15:07:29 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1271470, encodeId=0cbc12e1470cd, content=<a href='/topic/show?id=a0ff950018f' target=_blank style='color:#2F92EE;'>#造血干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95001, encryptionId=a0ff950018f, topicName=造血干细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e729101, createdName=huanbaofeng, createdTime=Fri Oct 12 13:17:00 CST 2018, time=2018-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1482194, encodeId=09e7148219453, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Fri Oct 12 13:17:00 CST 2018, time=2018-10-12, status=1, ipAttribution=)]
  7. 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content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Fri Oct 12 13:17:00 CST 2018, time=2018-10-12, status=1, ipAttribution=)]
    2019-04-19 gwc392
  8. 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    2018-10-13 orangesking

    0

  9. 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