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Free Radic Biol Med：小心！DTC和绿茶提取物具有协同毒性！

2017-10-26 MedSci MedSci原创

二硫代氨基甲酸酯绿茶提取物协同毒性
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DTC（二硫代氨基甲酸酯）作为农药以及杀菌剂等被广泛应用于农业，工业以及医疗领域，人类经常暴露于DTC环境下。

为了防治植物病虫害，全球每年有460多万吨化学农药被喷洒到自然环境中。环境中的农药在气象条件及生物作用下，在各环境要素间循环，造成农药在环境中重新分布，使其污染范围极大扩散,致使全球大气、水体（地表水、地下水）、土壤和生物体内都含有农药及其残留。曾被视为"环境净土"的地球两极，由于大气环流、海洋洋流及生物富集等综合作用，在格陵兰冰层、南极企鹅体内,均已检测出DDT等农药残留。我国是世界农药生产和使用大国，且以使用杀虫剂为主,致使不少地区土壤、水体及粮食、蔬菜、水果中农药的残留量大大超过国家安全标准，对环境、生物及人体健康构成了严重威胁。

DTC（二硫代氨基甲酸酯）作为农药以及杀菌剂等被广泛应用于农业，工业以及医疗领域，人类经常暴露于DTC环境下。绿茶提取物中含有大量表没食子儿茶素-3-没食子酸酯（EGCG），这种物质已用作减轻体重时的膳食补充剂。

研究人员推测，DTC可能作为铜离子载体来增加肝脏中氧化还原活性铜的水平，促进EGCG自氧化产生氧化应激和毒性，研究结果证实了这一推测。暴露于DTC会降低来自绿茶以及其他植物膳食多酚的毒性阈值，反之亦然。该研究结果对于两种物质的应用非常重要，协同毒性的剂量以及反应关系仍需要进一步研究。
在小鼠模型中，EGCG和双硫仑代谢物（二乙基二硫代氨基甲酸盐）均在可耐受水平下时，共同给药会引起小鼠致死。肝脏是去除毒素的主要器官，当共同施药时会显著增加脂质过氧化、DNA损伤、细胞凋亡并引起有害的转录反应，导致肝脏中基础以及Nrf2抗氧化系统损伤。

原始出处：

Zhang K, et al. Synergistic toxicity of epigallocatechin-3-gallate and diethyldithiocarbamate, a lethal encounter involving redox-active copper. Free RadicBiol Med. 2017 Sep 30;113:143-156. doi: 10.1016/j.freeradbiomed.2017.09.027.

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    2018-07-02 jeanqiuqiu

    #DIC#

    0

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    2018-07-12 12498ebem31暂无昵称

    #Biol#

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    2017-12-08 sunylz

    #Bio#

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    2017-10-28 hbwxf

    #茶#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1858813, encodeId=e6871858813d4, content=<a href='/topic/show?id=e0a9593596' target=_blank style='color:#2F92EE;'>#DIC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5935, encryptionId=e0a9593596, topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Mon Jul 02 06:48:00 CST 2018, time=2018-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767286, encodeId=d3861e672868c, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Thu Jul 12 10:48:00 CST 2018, time=2018-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917738, encodeId=a62b191e738f1, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Fri Dec 08 12:48:00 CST 2017, time=2017-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402330, encodeId=6efe1402330a2, content=<a href='/topic/show?id=862e8e196a1' target=_blank style='color:#2F92EE;'>#茶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87196, encryptionId=862e8e196a1, topicName=茶)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/eTyQ1TyLVfyaGrflWSd1Jw4u1F68ibicmN32DE38FjEW3zTIKeFeaMUAQsjyqaL4QZ3lRibFIzziacMz9niceznOTTw/132, createdBy=03082405249, createdName=hbwxf, createdTime=Sat Oct 28 01:48:00 CST 2017, time=2017-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608161, encodeId=c0bb160816187, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Oct 28 01:48:00 CST 2017, time=2017-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=256105, encodeId=23772561057d, content=农药越弄越多.怪病也越来越多.有没有想过.如果没有那么多农药.最终进我们肚子的食物.会否更绿色天然?, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210427/b594a756d77e4171b5313e531ef89b43/31c000a8a97d4872b698c80fb8a33369.jpg, createdBy=624b2152505, createdName=大叔默默路过, createdTime=Thu Oct 26 11:27:53 CST 2017, time=2017-10-26, status=1, ipAttribution=)]
    2017-10-28 ms3994565386320060

    #Med#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1858813, encodeId=e6871858813d4, content=<a href='/topic/show?id=e0a9593596' target=_blank style='color:#2F92EE;'>#DIC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5935, encryptionId=e0a9593596, topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Mon Jul 02 06:48:00 CST 2018, time=2018-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767286, encodeId=d3861e672868c, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Thu Jul 12 10:48:00 CST 2018, time=2018-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917738, encodeId=a62b191e738f1, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Fri Dec 08 12:48:00 CST 2017, time=2017-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402330, encodeId=6efe1402330a2, content=<a href='/topic/show?id=862e8e196a1' target=_blank style='color:#2F92EE;'>#茶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87196, encryptionId=862e8e196a1, topicName=茶)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/eTyQ1TyLVfyaGrflWSd1Jw4u1F68ibicmN32DE38FjEW3zTIKeFeaMUAQsjyqaL4QZ3lRibFIzziacMz9niceznOTTw/132, createdBy=03082405249, createdName=hbwxf, createdTime=Sat Oct 28 01:48:00 CST 2017, time=2017-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608161, encodeId=c0bb160816187, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Oct 28 01:48:00 CST 2017, time=2017-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=256105, encodeId=23772561057d, content=农药越弄越多.怪病也越来越多.有没有想过.如果没有那么多农药.最终进我们肚子的食物.会否更绿色天然?, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210427/b594a756d77e4171b5313e531ef89b43/31c000a8a97d4872b698c80fb8a33369.jpg, createdBy=624b2152505, createdName=大叔默默路过, createdTime=Thu Oct 26 11:27:53 CST 2017, time=2017-10-26, status=1, ipAttribution=)]
    2017-10-26 大叔默默路过

    农药越弄越多.怪病也越来越多.有没有想过.如果没有那么多农药.最终进我们肚子的食物.会否更绿色天然?

    0