JAHA:妊娠高血压妇女未来心血管疾病风险

2020-06-25 MedSci原创 MedSci原创

妊娠高血压与整体心血管疾病、冠心病和心力衰竭更大风险相关。需要更多的研究来评估妊娠高血压与随后心血管疾病之间的剂量反应关系。

在评估妊娠高血压(新发高血压且无蛋白尿)孕妇血管疾病风险的研究中发现了不一致的结果。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员进行了一项研究综述,以量化妇女妊娠高血压与心血管事件之间的关系。

研究人员于2019年3月对PubMed、Embase和Web of Science进行了系统检索,以评估妊娠高血压与任何心血管事件之间的关系。两位研究者独立评估摘要和全文,并从符合条件的研究中提取出与妊娠高血压相关的心血管事件的研究特征和相对风险(RR)。在适当的情况下,将估计值与反方差加权随机效应荟萃分析合并。

该分析总共确定了21项研究,涉及3601192名妇女(127913名妊娠高血压妇女)。首次妊娠期间出现的妊娠高血压与总体心血管疾病(RR为1.45;95%CI为1.17-1.80)和冠心病(RR为1.46;95%CI为1.23-1.73)的风险较高,但与卒中(RR为1.26;95%CI为0.96-1.55)或血栓栓塞事件(RR为0.88;95%CI为0.73-1.07)无关。1次以上妊娠出现妊娠高血压的孕妇罹患心血管疾病(RR为1.81;95%CI为1.42-2.31)、冠心病(RR为1.83;95%CI为1.33-2.51)和心衰(RR为1.77;95%CI为1.47-2.13)的风险更高,但卒中则不然(RR为1.50;95%CI为0.75–2.99)。

由此可见,妊娠高血压与整体心血管疾病、冠心病和心力衰竭更大风险相关。需要更多的研究来评估妊娠高血压与随后心血管疾病之间的剂量反应关系。

原始出处:

Charmaine Chu Wen Lo.et al.Future Cardiovascular Disease Risk for Women With Gestational Hypertension: A Systematic Review and Meta‐Analysis.JAHA.2020.https://www.ahajournals.org/doi/full/10.1161/JAHA.119.013991

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    2020-08-07 咻凡

    这个杂志周期多久

    0

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    2020-06-27 zhaohui6731
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    2020-06-25 IVF密密

    妊娠高血压这一类妊娠疾病,需要加强关注,甚至包括妊娠心肌病

    0

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