BMJ:围手术期干预与术后肺部并发症风险

2020-03-12 MedSci原创 MedSci原创

近日研究人员考察了围手术期干预措施对减少成人非心脏手术患者术后肺部并发症(PPCs)的效果。

近日研究人员考察了围手术期干预措施对减少成人非心脏手术患者术后肺部并发症(PPCs)的效果。

本次研究为系统综述及荟萃分析研究,收集1990-2017年间相关数据。研究的主要结果是PPCs发生率。次要结果是呼吸道感染、肺不张、住院时间和死亡率。

117项试验,总计21940名参与者,考察了11类干预措施。没有发现高质量的证据表明可以采取干预措施来减少(PPCs的发生率。七项干预措施具有低或中等的证据质量表明可降低PPCs风险,包括恢复途径干预(风险比0.35)、预防性粘溶性药物 (0.40)、术后持续气道正压通气(0.49)、术中肺保护性通气(0.52)、预防性呼吸物理疗法(0.55)、硬膜外镇痛(0.77)以及目标导向血流动力学治疗(0.87)。中等质量的证据显示激励性肺活量测定法对预防PPCs没有益处。序贯分析支持预防性呼吸物理疗法、硬膜外镇痛、恢复途径干预和目标导向血流动力学疗法对PPC相对风险降低有效。

研究认为,围手术期干预对降低非心脏手术患者术后肺部并发症风险有效的证据质量普遍较低。

原始出处:

Peter M Odor et al. Perioperative interventions for prevention of postoperative pulmonary complications: systematic review and meta-analysis.BMJ. 11 March 2020.

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    2020-10-02 gaoxiaoe
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    2020-08-12 丁鹏鹏
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