J Clin Periodontol: 牙周治疗限制牙周炎患者血小板活化的试验

2018-09-10 MedSci MedSci原创

牙周炎导致血小板活化并增加心血管疾病的风险。目前尚不清楚牙周治疗是否会逆转血小板高反应性,我本实验旨在研究牙周治疗对血小板活化的作用。

牙周炎导致血小板活化并增加血管疾病的风险。目前尚不清楚牙周治疗是否会逆转血小板高反应性,我本实验旨在研究牙周治疗对血小板活化的作用。

实验招募了52名患者并随机选择进行牙周治疗或监测3个月未进行治疗。通过流式细胞术分析患者血液中的血小板活化标记物,并通过光透射聚集法测定血小板聚集以响应促血栓形成刺激物。

结果:在这项研究中,对照组血小板活化在3个月的观察期内加重,而接受牙周治疗的患者显示血小板活化水平不变,通过CD62P,CD40L的表面表达,活性氧产生,GPIIb活化来测量/ IIIa和纤维蛋白原结合。此外,通过血小板RNA含量和响应于胶原的血小板聚集测量的血小板更新在治疗和未治疗的患者之间显着不同。

龈下清创术降低了血小板活化加重的风险,因此可能会减少牙周病患者的后续疾病,如血管疾病。

原始出处:

Markus Laky, et al.Periodontal treatment limits platelet activation in patients with periodontitis—a controlled‐randomized intervention trial. Journal of Clinical Periodontology. 2018 September. doi:10.1111/jcpe.12980

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    2018-11-02 feather89
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    2018-09-10 天地飞扬

    了解一下,谢谢分享!

    0

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    2018-09-10 小小小麦兜

    学习了

    0

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