Chest:估计的心室大小、哮喘严重程度与急性发作

2019-09-14 xing.T MedSci原创

由此可见,在哮喘患者中,较小的心室大小可能与更严重的疾病和更高的哮喘急性发作率相关。

胸部计算机断层扫描(CT)中肺动脉(PA)的相对增大与慢性阻塞性肺病或囊性纤维化患者的呼吸功能急剧加重有关。近日,呼吸领域权威杂志chest上发表了一篇研究文章,研究人员试图确定哮喘患者是否存在类似的结果,以及是否通过心室大小的差异来解释。

研究人员测量了来自严重哮喘研究计划III队列的233名受试者的PA和主动脉直径,还估计了受试者右、左心室和心外膜心室容积指数(分别为eERVVI、eELVVI和eETVVI)。研究人员使用Pearson相关性评估心脏与PA测量值(PA与主动脉比率(PA/A)、eERVVI与eELVVI比率(eRV/eLV)、eERVVI、eELVVI、eETVVI)与哮喘严重程度的临床指标之间的关联,并使用多变量线性和零膨胀负二项式回归评估与哮喘严重程度和恶化率之间的相关性。

哮喘严重程度与较小的心室容量相关。例如,严重哮喘患者eETVVI比健康对照组小36.1 mL/m2(p=0.003),eETVVI比轻度/中度疾病患者小14.1 mL/m2(p=0.011)。较小的心室容量也与较高的哮喘急性发作率相关,无论是回顾性还是前瞻性。例如,那些eETVVI小于中位数的患者在随访期间的急性发作率比eETVVI大于中位数的患者高57%(p=0.020)。PA/A和eRV/eLV均与哮喘严重程度或恶化无关。

由此可见,在哮喘患者中,较小的心室大小可能与更严重的疾病和更高的哮喘急性发作率相关。 

原始出处:

Samuel Y. Ash,et al.Estimated Ventricular Size, Asthma Severity and Exacerbations: The SARP III Cohort.chest.2019.https://doi.org/10.1016/j.chest.2019.08.2185

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    2020-01-13 zhouqu_8
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    2019-11-21 Smile2680
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