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晒太阳要适度！复旦大学团队发现：每天户外光照1.5小时，患痴呆的风险最低！

2022-07-13 Swagpp MedSci原创

痴呆症户外光照
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BMC子刊：光照时间与痴呆风险呈现J型关系，即平均每日晒太阳1.5小时（夏季每日2小时，冬季每日1小时），与最低的罹患痴呆风险相关。

太久不见时常想念，天天见面热到放电。
——打一自然物（小编自己编的谜语）
 
热！热！热！这是最近听到最多的呐喊声。
 
六月末七月初，中国呈现出南蒸北烤的局面，大部分地区都加入了“地表最强铁板烧”群聊，多地气温更是直逼40℃。超长待机的太阳公公，更是让大家渴望“雨神”萧敬腾能搬来自己的城市。
 
图片
图源：中国天气
 
当然，长期的炙烤确实令人有些受不了，但适度的光照确实能带来不小的好处。不仅可以促进人体内维生素D的合成，还能改善情绪和睡眠节律，甚至可以降低罹患痴呆的风险！
 
近日，来自复旦大学附属华山医院的郁金泰教授团队联合青岛市市立医院谭兰教授团队开展的一项针对超36万人的前瞻性队列研究发现：光照时间与痴呆风险呈现J型关系，即平均每日晒太阳1.5小时（夏季每日2小时，冬季每日1小时），与最低的罹患痴呆风险相关。该论文发表于BMC Medicine上。
 
图片
https://doi.org/10.1186/s12916-022-02331-2
 
研究者从英国生物银行（UK Biobank）中招募了约50万名年龄在37-73岁之间的参与者，收集他们冬夏两季在户外度过的时间，即户外照明的持续时间。而痴呆综合症的诊断，是根据国际疾病分类第9/10次修订版（ICD9和ICD10）确定的。
 
经过纳入排除标准，研究最终分析了362,094名参与者的数据。其中，4149人（1.15%）在中位随访的9.01年期间，被首次诊断出痴呆症。与健康的相比，这些发展成为痴呆症患者的参与者往往年龄更大、受教育程度更低、从未或很少防晒、睡眠时长更短、吸烟饮酒更多、较高的PM2.5暴露量等（p<0.05）。
 
有意思的是，罹患痴呆症的参与者在户外光照的平均时间显著长于未发生痴呆症的（p<0.001），前者比后者约长0.5小时/天。
 
那么问题来了，光照和痴呆到底存在怎样的量效关系？难道多晒太阳反而会增加患痴呆症的风险吗？
 
图片
根据痴呆事件划分的参与者基线特征
 
为了回答这一问题，研究者使用了限制性立方样条（Restricted cubic spline，RCS）的分析方法，来探究阳光照射时间与全因痴呆风险之间的非线性关系。
 
结果显示，与平均每天接受1.5小时户外光照的参与者相比，更少或更多地晒太阳均会导致罹患痴呆风险的升高。换句话说，阳光照射时间与罹患痴呆症的风险存在“J型”关系，即在低暴露下，观察到风险显著增加；而在较长时间的阳光照射下，患痴呆的风险升高相对缓慢。
 
下图模型表明，平均每天晒1.5小时的太阳，具体为夏季2小时/天，冬季1小时/天，可最显著地降低罹患痴呆的风险。
 
图片

户外光照时间与痴呆事件的相关性

 
Cox比例风险回归模型的数据揭示，在排除了性别和年龄等混杂因素后，与平均每日晒1.5小时太阳相比，每减少0.5小时的户外光照时长，参与者罹患痴呆的风险会增加35.3%；每增加0.5小时的户外光照时长，患痴呆的风险会增加7.1%。
 
具体来说，夏冬两季的情况分别为：夏季，与每天光照2小时相比，每减少或增加1小时，罹患痴呆症的风险分别增加23.2%和3.2%；冬季，与每天光照1小时相比，每减少或增加1小时，罹患痴呆症的风险分别增加18.2%和9.9%。
 
图片
在阳光照射变化点上下发生痴呆的风险（连续变量）
 
此外，研究者还发现，在60岁及以上的老年人群中，最佳“降低患痴呆风险”的光照时间会略长于整体。
 
J型关系图显示，最低痴呆风险值对应的时间为平均每天晒2小时，比所有人群长半小时左右。具体而言，夏季约3小时/天，冬季约1小时/天，可最显著地降低老年人罹患痴呆的风险。
 
图片
与年轻人相比，60岁以上的老年人更加需要光照
 
其实，“阳光的照射”与认知衰退之间存在的J型关联，是很好理解的。
 
光照时间延长会增加人体内维生素D的合成，而维生素D的受体又广泛存在于神经元和神经胶质细胞中，参与大脑健康相关的多条关键途径，包括神经传递、免疫反应调节、氧化应激调节等等，从而延缓老年人认知能力下降的进程。
 
此外，户外的日照还能通过调节昼夜节律、影响“人体内时钟”视交叉上核，进而对人体的生理和认知功能产生作用。因此，缺少日照会对人类的认知功能存在负作用。
 
不过凡事过犹不及~
 
过度的阳光照射，也对人类健康存在许多危害，包括晒伤、皮肤癌、眼部疾病等。在直立状态下，人类头部会直接暴露于太阳辐射之下，使得大脑温度升高到甚至超过核心温度，而广谱光可以穿透皮肤数毫米并加热下层组织，同样导致认知能力下降。
 
综上，作为全球首个探究光照与痴呆风险之间非线性关系的超大样本前瞻性研究，研究者发现了户外阳光照射时间与全因痴呆症风险之间存在的J型相关性，并探索出了“适量光照”的具体时长，即平均每天晒太阳1.5小时，夏季2小时/天，冬季1小时/天，可帮助人们最大化“晒太阳降低痴呆风险”的好处，有效预防痴呆症。
 
无论夏季还是冬季，都应鼓励爸妈多去户外适量晒太阳，以预防痴呆。不过，这么炎热的天气下，在“晒太阳防痴呆”之前，还是先防中暑吧。
 
图片
这么热的天，痴呆就痴呆吧（摆烂）
 

参考文献：

[1]Ma, LZ., Ma, YH., Ou, YN. et al. Time spent in outdoor light is associated with the risk of dementia: a prospective cohort study of 362094 participants. BMC Med 20, 132 (2022). https://doi.org/10.1186/s12916-022-02331-2

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1951647, encodeId=d562195164e7f, content=<a href='/topic/show?id=bd5259e63d9' target=_blank style='color:#2F92EE;'>#晒太阳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59763, encryptionId=bd5259e63d9, topicName=晒太阳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, createdName=amyloid, createdTime=Mon Apr 24 15:08:07 CST 2023, time=2023-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508967, encodeId=d619150896eca, content=<a href='/topic/show?id=0bc628824a4' target=_blank style='color:#2F92EE;'>#光照#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28824, encryptionId=0bc628824a4, topicName=光照)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=341f10021070, createdName=TZF0807, createdTime=Thu Jul 14 13:08:07 CST 2022, time=2022-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538651, encodeId=6409153865122, content=<a href='/topic/show?id=751e42660f1' target=_blank style='color:#2F92EE;'>#复旦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42660, encryptionId=751e42660f1, topicName=复旦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6c312994908, createdName=saikp, createdTime=Thu Jul 14 13:08:07 CST 2022, time=2022-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1232285, encodeId=d06512322858a, content=如果过犹不及的原因如文章所说是广谱光穿透皮肤并加热下层组织，导致认知能力下降，哪为什么夏天2小时而冬天1小时？, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc928173811, createdName=ms4000001114581575, createdTime=Wed Jul 13 18:46:30 CST 2022, time=2022-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1232174, encodeId=bf4412321e485, content=不错学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4dfa6526517, createdName=ms5000000644045955, createdTime=Wed Jul 13 08:19:46 CST 2022, time=2022-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1247138, encodeId=1f76124e13813, content=老年性痴呆，未来还是希望借助神经电生理吧，也许更为有效！, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Wed Jul 13 01:08:07 CST 2022, time=2022-07-13, status=1, ipAttribution=)]
    2023-04-24 amyloid

    #晒太阳#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1951647, encodeId=d562195164e7f, content=<a href='/topic/show?id=bd5259e63d9' target=_blank style='color:#2F92EE;'>#晒太阳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59763, encryptionId=bd5259e63d9, topicName=晒太阳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, createdName=amyloid, createdTime=Mon Apr 24 15:08:07 CST 2023, time=2023-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508967, encodeId=d619150896eca, content=<a href='/topic/show?id=0bc628824a4' target=_blank style='color:#2F92EE;'>#光照#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28824, encryptionId=0bc628824a4, topicName=光照)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=341f10021070, createdName=TZF0807, createdTime=Thu Jul 14 13:08:07 CST 2022, time=2022-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538651, encodeId=6409153865122, content=<a href='/topic/show?id=751e42660f1' target=_blank style='color:#2F92EE;'>#复旦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42660, encryptionId=751e42660f1, topicName=复旦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6c312994908, createdName=saikp, createdTime=Thu Jul 14 13:08:07 CST 2022, time=2022-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1232285, encodeId=d06512322858a, content=如果过犹不及的原因如文章所说是广谱光穿透皮肤并加热下层组织，导致认知能力下降，哪为什么夏天2小时而冬天1小时？, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc928173811, createdName=ms4000001114581575, createdTime=Wed Jul 13 18:46:30 CST 2022, time=2022-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1232174, encodeId=bf4412321e485, content=不错学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4dfa6526517, createdName=ms5000000644045955, createdTime=Wed Jul 13 08:19:46 CST 2022, time=2022-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1247138, encodeId=1f76124e13813, content=老年性痴呆，未来还是希望借助神经电生理吧，也许更为有效！, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Wed Jul 13 01:08:07 CST 2022, time=2022-07-13, status=1, ipAttribution=)]
    2022-07-14 TZF0807

    #光照#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1951647, encodeId=d562195164e7f, content=<a href='/topic/show?id=bd5259e63d9' target=_blank style='color:#2F92EE;'>#晒太阳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59763, encryptionId=bd5259e63d9, topicName=晒太阳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, createdName=amyloid, createdTime=Mon Apr 24 15:08:07 CST 2023, time=2023-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508967, encodeId=d619150896eca, content=<a href='/topic/show?id=0bc628824a4' target=_blank style='color:#2F92EE;'>#光照#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28824, encryptionId=0bc628824a4, topicName=光照)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=341f10021070, createdName=TZF0807, createdTime=Thu Jul 14 13:08:07 CST 2022, time=2022-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538651, encodeId=6409153865122, content=<a href='/topic/show?id=751e42660f1' target=_blank style='color:#2F92EE;'>#复旦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42660, encryptionId=751e42660f1, topicName=复旦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6c312994908, createdName=saikp, createdTime=Thu Jul 14 13:08:07 CST 2022, time=2022-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1232285, encodeId=d06512322858a, content=如果过犹不及的原因如文章所说是广谱光穿透皮肤并加热下层组织，导致认知能力下降，哪为什么夏天2小时而冬天1小时？, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc928173811, createdName=ms4000001114581575, createdTime=Wed Jul 13 18:46:30 CST 2022, time=2022-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1232174, encodeId=bf4412321e485, content=不错学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4dfa6526517, createdName=ms5000000644045955, createdTime=Wed Jul 13 08:19:46 CST 2022, time=2022-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1247138, encodeId=1f76124e13813, content=老年性痴呆，未来还是希望借助神经电生理吧，也许更为有效！, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Wed Jul 13 01:08:07 CST 2022, time=2022-07-13, status=1, ipAttribution=)]
    2022-07-14 saikp

    #复旦#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1951647, encodeId=d562195164e7f, content=<a href='/topic/show?id=bd5259e63d9' target=_blank style='color:#2F92EE;'>#晒太阳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59763, encryptionId=bd5259e63d9, topicName=晒太阳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, createdName=amyloid, createdTime=Mon Apr 24 15:08:07 CST 2023, time=2023-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508967, encodeId=d619150896eca, content=<a href='/topic/show?id=0bc628824a4' target=_blank style='color:#2F92EE;'>#光照#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28824, encryptionId=0bc628824a4, topicName=光照)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=341f10021070, createdName=TZF0807, createdTime=Thu Jul 14 13:08:07 CST 2022, time=2022-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538651, encodeId=6409153865122, content=<a href='/topic/show?id=751e42660f1' target=_blank style='color:#2F92EE;'>#复旦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42660, encryptionId=751e42660f1, topicName=复旦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6c312994908, createdName=saikp, createdTime=Thu Jul 14 13:08:07 CST 2022, time=2022-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1232285, encodeId=d06512322858a, content=如果过犹不及的原因如文章所说是广谱光穿透皮肤并加热下层组织，导致认知能力下降，哪为什么夏天2小时而冬天1小时？, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc928173811, createdName=ms4000001114581575, createdTime=Wed Jul 13 18:46:30 CST 2022, time=2022-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1232174, encodeId=bf4412321e485, content=不错学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4dfa6526517, createdName=ms5000000644045955, createdTime=Wed Jul 13 08:19:46 CST 2022, time=2022-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1247138, encodeId=1f76124e13813, content=老年性痴呆，未来还是希望借助神经电生理吧，也许更为有效！, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Wed Jul 13 01:08:07 CST 2022, time=2022-07-13, status=1, ipAttribution=)]
    2022-07-13 ms4000001114581575

    如果过犹不及的原因如文章所说是广谱光穿透皮肤并加热下层组织，导致认知能力下降，哪为什么夏天2小时而冬天1小时？

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1951647, encodeId=d562195164e7f, content=<a href='/topic/show?id=bd5259e63d9' target=_blank style='color:#2F92EE;'>#晒太阳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59763, encryptionId=bd5259e63d9, topicName=晒太阳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, createdName=amyloid, createdTime=Mon Apr 24 15:08:07 CST 2023, time=2023-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508967, encodeId=d619150896eca, content=<a href='/topic/show?id=0bc628824a4' target=_blank style='color:#2F92EE;'>#光照#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28824, encryptionId=0bc628824a4, topicName=光照)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=341f10021070, createdName=TZF0807, createdTime=Thu Jul 14 13:08:07 CST 2022, time=2022-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538651, encodeId=6409153865122, content=<a href='/topic/show?id=751e42660f1' target=_blank style='color:#2F92EE;'>#复旦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42660, encryptionId=751e42660f1, topicName=复旦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6c312994908, createdName=saikp, createdTime=Thu Jul 14 13:08:07 CST 2022, time=2022-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1232285, encodeId=d06512322858a, content=如果过犹不及的原因如文章所说是广谱光穿透皮肤并加热下层组织，导致认知能力下降，哪为什么夏天2小时而冬天1小时？, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc928173811, createdName=ms4000001114581575, createdTime=Wed Jul 13 18:46:30 CST 2022, time=2022-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1232174, encodeId=bf4412321e485, content=不错学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4dfa6526517, createdName=ms5000000644045955, createdTime=Wed Jul 13 08:19:46 CST 2022, time=2022-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1247138, encodeId=1f76124e13813, content=老年性痴呆，未来还是希望借助神经电生理吧，也许更为有效！, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Wed Jul 13 01:08:07 CST 2022, time=2022-07-13, status=1, ipAttribution=)]
    2022-07-13 ms5000000644045955

    不错学习了。

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1951647, encodeId=d562195164e7f, content=<a href='/topic/show?id=bd5259e63d9' target=_blank style='color:#2F92EE;'>#晒太阳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59763, encryptionId=bd5259e63d9, topicName=晒太阳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, createdName=amyloid, createdTime=Mon Apr 24 15:08:07 CST 2023, time=2023-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508967, encodeId=d619150896eca, content=<a href='/topic/show?id=0bc628824a4' target=_blank style='color:#2F92EE;'>#光照#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28824, encryptionId=0bc628824a4, topicName=光照)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=341f10021070, createdName=TZF0807, createdTime=Thu Jul 14 13:08:07 CST 2022, time=2022-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538651, encodeId=6409153865122, content=<a href='/topic/show?id=751e42660f1' target=_blank style='color:#2F92EE;'>#复旦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42660, encryptionId=751e42660f1, topicName=复旦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6c312994908, createdName=saikp, createdTime=Thu Jul 14 13:08:07 CST 2022, time=2022-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1232285, encodeId=d06512322858a, content=如果过犹不及的原因如文章所说是广谱光穿透皮肤并加热下层组织，导致认知能力下降，哪为什么夏天2小时而冬天1小时？, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc928173811, createdName=ms4000001114581575, createdTime=Wed Jul 13 18:46:30 CST 2022, time=2022-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1232174, encodeId=bf4412321e485, content=不错学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4dfa6526517, createdName=ms5000000644045955, createdTime=Wed Jul 13 08:19:46 CST 2022, time=2022-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1247138, encodeId=1f76124e13813, content=老年性痴呆，未来还是希望借助神经电生理吧，也许更为有效！, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Wed Jul 13 01:08:07 CST 2022, time=2022-07-13, status=1, ipAttribution=)]
    2022-07-13 neuro.Dr

    老年性痴呆，未来还是希望借助神经电生理吧，也许更为有效！

    0

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