J Neurogastroenterol Motil:慢性咳嗽与食管蠕动完整性的长期紊乱有关

2018-08-12 MedSci MedSci原创

食道高分辨率测压(HRM)的蠕动轮廓的断裂可能与食管中的推注保留有关。我们评估了前瞻性患者队列中蠕动断裂与食管症状,反流暴露和症状结果之间的关系。前瞻性评估了在5年内进行pH阻抗测试和HRM的218名患者(53.2±0.9年,68.3%为女性)。收集人口统计学,症状表现,酸暴露时间,症状关联概率和症状负担评分。使用症状评分的变化评估随访结果。评估HRM长间歇(≥5cm)的存在。评估休息,反流参数,

食道高分辨率测压(HRM)的蠕动轮廓的断裂可能与食管中的推注保留有关。我们评估了前瞻性患者队列中蠕动断裂与食管症状,反流暴露和症状结果之间的关系。

前瞻性评估了在5年内进行pH阻抗测试和HRM的218名患者(53.2±0.9年,68.3%为女性)。收集人口统计学,症状表现,酸暴露时间,症状关联概率和症状负担评分。使用症状评分的变化评估随访结果。评估HRM长间歇(≥5cm)的存在。评估休息,反流参数,呈现症状和结果之间的关系。

结果显示,长间歇的患者较未有长间歇者更容易出现咳嗽(43.4% vs 28.6%,P = 0.024);其他症状未发现统计学差异(P≥0.3)。与没有咳嗽的患者相比,咳嗽患者的长间歇数量较多(2.4±0.3 vs 1.6±0.2,P = 0.021);其他症状未发现差异(P≥0.4)。长间歇与年龄,性别,种族,反流负担,症状关联或症状指标的变化无关(所有比较P均为0.1)。在患有咳嗽的患者中,长间歇的存在预示了抗反流治疗的症状改善次优(P = 0.018);这种差异并不适用于其他症状(P≥0.2)。

综上所述,该研究结果表明,食道蠕动完整性的长间歇与咳嗽有关。长间歇与抗反流治疗的次优益处相关。

原始出处:


Bennett MC, Patel A, et al., Chronic Cough Is Associated With Long Breaks in Esophageal Peristaltic Integrity on High-resolution Manometry. J Neurogastroenterol Motil. 2018 Jul 30;24(3):387-394. doi: 10.5056/jnm17126.

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    2019-01-18 许安
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    2018-08-14 zhouqu_8