蓝鸟生物针对脑性肾上腺皮质营养不良症的慢病毒基因疗法,临床展现出积极数据

2019-09-25 不详 MedSci原创

蓝鸟生物公司宣布其慢病毒基因疗法Lenti-D针对脑性肾上腺皮质营养不良症(CALD)患者的临床研究最新结果。该研究的主要疗效终点是在第24个月存活且没有重大功能障碍的患者比例。在已经进行24个月随访的患者中,有88%存活且无主要功能障碍。

蓝鸟生物公司宣布其慢病毒基因疗法Lenti-D针对脑性肾上腺皮质营养不良症(CALD)患者的临床研究最新结果。该研究的主要疗效终点是在第24个月存活且没有重大功能障碍的患者比例。在已经进行24个月随访的患者中,有88%存活且无主要功能障碍。

进一步的数据表明,在32名接受治疗的患者中,有3名未达到或将不会达到主要疗效终点。两名患者因"研究者的酌情决定权"而退出研究,而一名患者在研究初期就经历了疾病的快速进展,导致MFD和死亡。

"目前,对II / III期Starbeam研究的最长随访时间长达五年,数据显示,所有接受Lenti-D治疗且在24个月内没有严重功能障碍的CALD男孩仍保持无功能障碍。"该公司首席医疗官David Davidson解释说。

他继续说:"重要的是,没有移植失败或与治疗相关的死亡率的报道,不良反应通常与清髓性调理一致。这些结果支持了Lenti-D作为治疗CALD的潜力,我们希望这可能成为受这种破坏性疾病影响的男孩及其家庭的选择。"

CALD是肾上腺皮质营养不良(ALD)的最严重表现,一种罕见的代谢紊乱。大约有35-40%的被诊断为ALD的男孩会发展为CALD,通常在3至12岁之间。在大多数未经治疗的患者中,其特点是神经功能迅速下降,导致神经功能严重丧失和死亡。

原始出处:


本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (7)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2045233, encodeId=164e204523325, content=<a href='/topic/show?id=273b53e546c' target=_blank style='color:#2F92EE;'>#慢病毒基因疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53754, encryptionId=273b53e546c, topicName=慢病毒基因疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c0050, createdName=lishiwen, createdTime=Tue Oct 15 09:27:00 CST 2019, time=2019-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2046726, encodeId=1d5d2046e26ae, content=<a href='/topic/show?id=e4648838587' target=_blank style='color:#2F92EE;'>#蓝鸟生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88385, encryptionId=e4648838587, topicName=蓝鸟生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Tue Dec 17 10:27:00 CST 2019, time=2019-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1810402, encodeId=bd971810402d6, content=<a href='/topic/show?id=9db084864dd' target=_blank style='color:#2F92EE;'>#脑性肾上腺皮质营养不良症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84864, encryptionId=9db084864dd, topicName=脑性肾上腺皮质营养不良症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Mon Jul 20 23:27:00 CST 2020, time=2020-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895189, encodeId=db67189518949, content=<a href='/topic/show?id=ce478241e0b' target=_blank style='color:#2F92EE;'>#肾上腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82417, encryptionId=ce478241e0b, topicName=肾上腺)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8dba135, createdName=xuyong523, createdTime=Tue Jul 21 05:27:00 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1803242, encodeId=980a180324260, content=<a href='/topic/show?id=7ef0e51191e' target=_blank style='color:#2F92EE;'>#积极数据#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75119, encryptionId=7ef0e51191e, topicName=积极数据)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK17mLkWpia3T92NlEWTkEhrhZa7XPNic2JqQumEicZXGYFG6Ww5SCIl0Uq62bhhPnibAqIZDHtRva92A/132, createdBy=e0752500025, createdName=江川靖瑶, createdTime=Tue Sep 08 20:27:00 CST 2020, time=2020-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401550, encodeId=827c1401550c7, content=<a href='/topic/show?id=b9c853e521b' target=_blank style='color:#2F92EE;'>#慢病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53752, encryptionId=b9c853e521b, topicName=慢病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9bf2348479, createdName=ymljack, createdTime=Fri Sep 27 11:27:00 CST 2019, time=2019-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=373190, encodeId=445a3e31905b, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Wed Sep 25 20:44:09 CST 2019, time=2019-09-25, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=2045233, encodeId=164e204523325, content=<a href='/topic/show?id=273b53e546c' target=_blank style='color:#2F92EE;'>#慢病毒基因疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53754, encryptionId=273b53e546c, topicName=慢病毒基因疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c0050, createdName=lishiwen, createdTime=Tue Oct 15 09:27:00 CST 2019, time=2019-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2046726, encodeId=1d5d2046e26ae, content=<a href='/topic/show?id=e4648838587' target=_blank style='color:#2F92EE;'>#蓝鸟生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88385, encryptionId=e4648838587, topicName=蓝鸟生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Tue Dec 17 10:27:00 CST 2019, time=2019-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1810402, encodeId=bd971810402d6, content=<a href='/topic/show?id=9db084864dd' target=_blank style='color:#2F92EE;'>#脑性肾上腺皮质营养不良症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84864, encryptionId=9db084864dd, topicName=脑性肾上腺皮质营养不良症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Mon Jul 20 23:27:00 CST 2020, time=2020-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895189, encodeId=db67189518949, content=<a href='/topic/show?id=ce478241e0b' target=_blank style='color:#2F92EE;'>#肾上腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82417, encryptionId=ce478241e0b, topicName=肾上腺)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8dba135, createdName=xuyong523, createdTime=Tue Jul 21 05:27:00 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1803242, encodeId=980a180324260, content=<a href='/topic/show?id=7ef0e51191e' target=_blank style='color:#2F92EE;'>#积极数据#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75119, encryptionId=7ef0e51191e, topicName=积极数据)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK17mLkWpia3T92NlEWTkEhrhZa7XPNic2JqQumEicZXGYFG6Ww5SCIl0Uq62bhhPnibAqIZDHtRva92A/132, createdBy=e0752500025, createdName=江川靖瑶, createdTime=Tue Sep 08 20:27:00 CST 2020, time=2020-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401550, encodeId=827c1401550c7, content=<a href='/topic/show?id=b9c853e521b' target=_blank style='color:#2F92EE;'>#慢病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53752, encryptionId=b9c853e521b, topicName=慢病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9bf2348479, createdName=ymljack, createdTime=Fri Sep 27 11:27:00 CST 2019, time=2019-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=373190, encodeId=445a3e31905b, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Wed Sep 25 20:44:09 CST 2019, time=2019-09-25, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=2045233, encodeId=164e204523325, content=<a href='/topic/show?id=273b53e546c' target=_blank style='color:#2F92EE;'>#慢病毒基因疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53754, encryptionId=273b53e546c, topicName=慢病毒基因疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c0050, createdName=lishiwen, createdTime=Tue Oct 15 09:27:00 CST 2019, time=2019-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2046726, encodeId=1d5d2046e26ae, content=<a href='/topic/show?id=e4648838587' target=_blank style='color:#2F92EE;'>#蓝鸟生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88385, encryptionId=e4648838587, topicName=蓝鸟生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Tue Dec 17 10:27:00 CST 2019, time=2019-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1810402, encodeId=bd971810402d6, content=<a href='/topic/show?id=9db084864dd' target=_blank style='color:#2F92EE;'>#脑性肾上腺皮质营养不良症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84864, encryptionId=9db084864dd, topicName=脑性肾上腺皮质营养不良症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Mon Jul 20 23:27:00 CST 2020, time=2020-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895189, encodeId=db67189518949, content=<a href='/topic/show?id=ce478241e0b' target=_blank style='color:#2F92EE;'>#肾上腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82417, encryptionId=ce478241e0b, topicName=肾上腺)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8dba135, createdName=xuyong523, createdTime=Tue Jul 21 05:27:00 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1803242, encodeId=980a180324260, content=<a href='/topic/show?id=7ef0e51191e' target=_blank style='color:#2F92EE;'>#积极数据#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75119, encryptionId=7ef0e51191e, topicName=积极数据)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK17mLkWpia3T92NlEWTkEhrhZa7XPNic2JqQumEicZXGYFG6Ww5SCIl0Uq62bhhPnibAqIZDHtRva92A/132, createdBy=e0752500025, createdName=江川靖瑶, createdTime=Tue Sep 08 20:27:00 CST 2020, time=2020-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401550, encodeId=827c1401550c7, content=<a href='/topic/show?id=b9c853e521b' target=_blank style='color:#2F92EE;'>#慢病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53752, encryptionId=b9c853e521b, topicName=慢病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9bf2348479, createdName=ymljack, createdTime=Fri Sep 27 11:27:00 CST 2019, time=2019-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=373190, encodeId=445a3e31905b, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Wed Sep 25 20:44:09 CST 2019, time=2019-09-25, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=2045233, encodeId=164e204523325, content=<a href='/topic/show?id=273b53e546c' target=_blank style='color:#2F92EE;'>#慢病毒基因疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53754, encryptionId=273b53e546c, topicName=慢病毒基因疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c0050, createdName=lishiwen, createdTime=Tue Oct 15 09:27:00 CST 2019, time=2019-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2046726, encodeId=1d5d2046e26ae, content=<a href='/topic/show?id=e4648838587' target=_blank style='color:#2F92EE;'>#蓝鸟生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88385, encryptionId=e4648838587, topicName=蓝鸟生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Tue Dec 17 10:27:00 CST 2019, time=2019-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1810402, encodeId=bd971810402d6, content=<a href='/topic/show?id=9db084864dd' target=_blank style='color:#2F92EE;'>#脑性肾上腺皮质营养不良症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84864, encryptionId=9db084864dd, topicName=脑性肾上腺皮质营养不良症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Mon Jul 20 23:27:00 CST 2020, time=2020-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895189, encodeId=db67189518949, content=<a href='/topic/show?id=ce478241e0b' target=_blank style='color:#2F92EE;'>#肾上腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82417, encryptionId=ce478241e0b, topicName=肾上腺)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8dba135, createdName=xuyong523, createdTime=Tue Jul 21 05:27:00 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1803242, encodeId=980a180324260, content=<a href='/topic/show?id=7ef0e51191e' target=_blank style='color:#2F92EE;'>#积极数据#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75119, encryptionId=7ef0e51191e, topicName=积极数据)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK17mLkWpia3T92NlEWTkEhrhZa7XPNic2JqQumEicZXGYFG6Ww5SCIl0Uq62bhhPnibAqIZDHtRva92A/132, createdBy=e0752500025, createdName=江川靖瑶, createdTime=Tue Sep 08 20:27:00 CST 2020, time=2020-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401550, encodeId=827c1401550c7, content=<a href='/topic/show?id=b9c853e521b' target=_blank style='color:#2F92EE;'>#慢病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53752, encryptionId=b9c853e521b, topicName=慢病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9bf2348479, createdName=ymljack, createdTime=Fri Sep 27 11:27:00 CST 2019, time=2019-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=373190, encodeId=445a3e31905b, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Wed Sep 25 20:44:09 CST 2019, time=2019-09-25, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=2045233, encodeId=164e204523325, content=<a href='/topic/show?id=273b53e546c' target=_blank style='color:#2F92EE;'>#慢病毒基因疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53754, encryptionId=273b53e546c, topicName=慢病毒基因疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c0050, createdName=lishiwen, createdTime=Tue Oct 15 09:27:00 CST 2019, time=2019-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2046726, encodeId=1d5d2046e26ae, content=<a href='/topic/show?id=e4648838587' target=_blank style='color:#2F92EE;'>#蓝鸟生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88385, encryptionId=e4648838587, topicName=蓝鸟生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Tue Dec 17 10:27:00 CST 2019, time=2019-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1810402, encodeId=bd971810402d6, content=<a href='/topic/show?id=9db084864dd' target=_blank style='color:#2F92EE;'>#脑性肾上腺皮质营养不良症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84864, encryptionId=9db084864dd, topicName=脑性肾上腺皮质营养不良症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Mon Jul 20 23:27:00 CST 2020, time=2020-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895189, encodeId=db67189518949, content=<a href='/topic/show?id=ce478241e0b' target=_blank style='color:#2F92EE;'>#肾上腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82417, encryptionId=ce478241e0b, topicName=肾上腺)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8dba135, createdName=xuyong523, createdTime=Tue Jul 21 05:27:00 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1803242, encodeId=980a180324260, content=<a href='/topic/show?id=7ef0e51191e' target=_blank style='color:#2F92EE;'>#积极数据#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75119, encryptionId=7ef0e51191e, topicName=积极数据)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK17mLkWpia3T92NlEWTkEhrhZa7XPNic2JqQumEicZXGYFG6Ww5SCIl0Uq62bhhPnibAqIZDHtRva92A/132, createdBy=e0752500025, createdName=江川靖瑶, createdTime=Tue Sep 08 20:27:00 CST 2020, time=2020-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401550, encodeId=827c1401550c7, content=<a href='/topic/show?id=b9c853e521b' target=_blank style='color:#2F92EE;'>#慢病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53752, encryptionId=b9c853e521b, topicName=慢病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9bf2348479, createdName=ymljack, createdTime=Fri Sep 27 11:27:00 CST 2019, time=2019-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=373190, encodeId=445a3e31905b, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Wed Sep 25 20:44:09 CST 2019, time=2019-09-25, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=2045233, encodeId=164e204523325, content=<a href='/topic/show?id=273b53e546c' target=_blank style='color:#2F92EE;'>#慢病毒基因疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53754, encryptionId=273b53e546c, topicName=慢病毒基因疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c0050, createdName=lishiwen, createdTime=Tue Oct 15 09:27:00 CST 2019, time=2019-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2046726, encodeId=1d5d2046e26ae, content=<a href='/topic/show?id=e4648838587' target=_blank style='color:#2F92EE;'>#蓝鸟生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88385, encryptionId=e4648838587, topicName=蓝鸟生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Tue Dec 17 10:27:00 CST 2019, time=2019-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1810402, encodeId=bd971810402d6, content=<a href='/topic/show?id=9db084864dd' target=_blank style='color:#2F92EE;'>#脑性肾上腺皮质营养不良症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84864, encryptionId=9db084864dd, topicName=脑性肾上腺皮质营养不良症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Mon Jul 20 23:27:00 CST 2020, time=2020-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895189, encodeId=db67189518949, content=<a href='/topic/show?id=ce478241e0b' target=_blank style='color:#2F92EE;'>#肾上腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82417, encryptionId=ce478241e0b, topicName=肾上腺)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8dba135, createdName=xuyong523, createdTime=Tue Jul 21 05:27:00 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1803242, encodeId=980a180324260, content=<a href='/topic/show?id=7ef0e51191e' target=_blank style='color:#2F92EE;'>#积极数据#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75119, encryptionId=7ef0e51191e, topicName=积极数据)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK17mLkWpia3T92NlEWTkEhrhZa7XPNic2JqQumEicZXGYFG6Ww5SCIl0Uq62bhhPnibAqIZDHtRva92A/132, createdBy=e0752500025, createdName=江川靖瑶, createdTime=Tue Sep 08 20:27:00 CST 2020, time=2020-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401550, encodeId=827c1401550c7, content=<a href='/topic/show?id=b9c853e521b' target=_blank style='color:#2F92EE;'>#慢病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53752, encryptionId=b9c853e521b, topicName=慢病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9bf2348479, createdName=ymljack, createdTime=Fri Sep 27 11:27:00 CST 2019, time=2019-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=373190, encodeId=445a3e31905b, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Wed Sep 25 20:44:09 CST 2019, time=2019-09-25, status=1, ipAttribution=)]
    2019-09-27 ymljack
  7. [GetPortalCommentsPageByObjectIdResponse(id=2045233, encodeId=164e204523325, content=<a href='/topic/show?id=273b53e546c' target=_blank style='color:#2F92EE;'>#慢病毒基因疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53754, encryptionId=273b53e546c, topicName=慢病毒基因疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c0050, createdName=lishiwen, createdTime=Tue Oct 15 09:27:00 CST 2019, time=2019-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2046726, encodeId=1d5d2046e26ae, content=<a href='/topic/show?id=e4648838587' target=_blank style='color:#2F92EE;'>#蓝鸟生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88385, encryptionId=e4648838587, topicName=蓝鸟生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Tue Dec 17 10:27:00 CST 2019, time=2019-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1810402, encodeId=bd971810402d6, content=<a href='/topic/show?id=9db084864dd' target=_blank style='color:#2F92EE;'>#脑性肾上腺皮质营养不良症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84864, encryptionId=9db084864dd, topicName=脑性肾上腺皮质营养不良症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Mon Jul 20 23:27:00 CST 2020, time=2020-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895189, encodeId=db67189518949, content=<a href='/topic/show?id=ce478241e0b' target=_blank style='color:#2F92EE;'>#肾上腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82417, encryptionId=ce478241e0b, topicName=肾上腺)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8dba135, createdName=xuyong523, createdTime=Tue Jul 21 05:27:00 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1803242, encodeId=980a180324260, content=<a href='/topic/show?id=7ef0e51191e' target=_blank style='color:#2F92EE;'>#积极数据#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75119, encryptionId=7ef0e51191e, topicName=积极数据)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK17mLkWpia3T92NlEWTkEhrhZa7XPNic2JqQumEicZXGYFG6Ww5SCIl0Uq62bhhPnibAqIZDHtRva92A/132, createdBy=e0752500025, createdName=江川靖瑶, createdTime=Tue Sep 08 20:27:00 CST 2020, time=2020-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401550, encodeId=827c1401550c7, content=<a href='/topic/show?id=b9c853e521b' target=_blank style='color:#2F92EE;'>#慢病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53752, encryptionId=b9c853e521b, topicName=慢病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9bf2348479, createdName=ymljack, createdTime=Fri Sep 27 11:27:00 CST 2019, time=2019-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=373190, encodeId=445a3e31905b, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Wed Sep 25 20:44:09 CST 2019, time=2019-09-25, status=1, ipAttribution=)]
    2019-09-25 医者仁心5538

    学习了

    0