JAHA:高血压人群对高原反应的血压变化研究

2018-06-10 MedSci MedSci原创

高血压人群对高原低压低氧的急性暴露会出现血压升高的现象,但这种现象是由于血压的高敏感性还是血压水平的上移导致尚属未知。本研究纳入了55例中度高血压的患者,随机双盲分成安慰剂组和血管紧张素受体拮抗剂联合钙通道阻滞剂治疗组,对其在海平面水平和3260m海拔高度进行了心肺运动试验。分析结果发现高海拔不仅使血压上移了8mmHg(P<0.01),同时也使每分钟收缩压变陡了0.4 mm Hg/mL/kg

高血压人群对高原低压低氧的急性暴露会出现血压升高的现象,但这种现象是由于血压的高敏感性还是血压水平的上移导致尚属未知。

本研究纳入了55例中度高血压的患者,随机双盲分成安慰剂组和血管紧张素受体拮抗剂联合钙通道阻滞剂治疗组,对其在海平面水平和3260m海拔高度进行了心肺运动试验。分析结果发现高海拔不仅使血压上移了8mmHg(P<0.01),同时也使每分钟收缩压变陡了0.4 mm Hg/mL/kg(P<0.05),替米沙坦和硝苯地平并不能改善血压对运动的敏感性,但是无论是海平面还是高原均下移了收缩压和耗氧量的关系。另外,海拔高度暴露对肌肉氧输送无影响,但替米沙坦/硝苯地平组患者的肌肉氧输送量高于安慰剂组(P<0.01)。

研究结果显示,高血压人群暴露于高海拔时,血压水平会上移伴随收缩压运动曲线更加陡峭,替米沙坦/硝苯地平可改善这些变化并增加肌肉的氧输送量。

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    2018-06-12 zhaohui6731
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    2018-06-12 jmtang
  5. [GetPortalCommentsPageByObjectIdResponse(id=1822344, encodeId=83181822344a4, content=<a href='/topic/show?id=c4fa1026584a' target=_blank style='color:#2F92EE;'>#高血压人群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102658, encryptionId=c4fa1026584a, topicName=高血压人群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Fri Jul 27 10:41:00 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1709690, encodeId=87a91e09690e9, content=<a href='/topic/show?id=4cc58893ea0' target=_blank style='color:#2F92EE;'>#血压变化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88937, encryptionId=4cc58893ea0, topicName=血压变化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f1b531772449, createdName=ms1467340776200723, createdTime=Wed Oct 31 14:41:00 CST 2018, time=2018-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267846, encodeId=b91d126e8461a, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Tue Jun 12 11:41:00 CST 2018, time=2018-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1574859, encodeId=360115e4859e2, content=<a href='/topic/show?id=6d6210228935' target=_blank style='color:#2F92EE;'>#高原#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102289, encryptionId=6d6210228935, topicName=高原)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=687116029883, createdName=jmtang, createdTime=Tue Jun 12 11:41:00 CST 2018, time=2018-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323360, encodeId=362e32336006, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/6r91EF8BMOLCD55MqUYf0ibGeibzcwCxaSD5XqTv5sRrxxzV9TpHfN8fDaNYCt8Jay98QLKHyzBpkr1f4v2EIcDQ/132, createdBy=c24466863, createdName=liuchuan1982, createdTime=Mon Jun 11 21:14:25 CST 2018, time=2018-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323139, encodeId=669132313944, content=不错的文章值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sun Jun 10 22:34:50 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323134, encodeId=150c32313478, content=不错的文章值得拥有哦!, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Sun Jun 10 22:21:51 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323119, encodeId=2d413231198a, content=好文章.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Jun 10 21:41:44 CST 2018, time=2018-06-10, status=1, ipAttribution=)]
    2018-06-11 liuchuan1982

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1822344, encodeId=83181822344a4, content=<a href='/topic/show?id=c4fa1026584a' target=_blank style='color:#2F92EE;'>#高血压人群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102658, encryptionId=c4fa1026584a, topicName=高血压人群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Fri Jul 27 10:41:00 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1709690, encodeId=87a91e09690e9, content=<a href='/topic/show?id=4cc58893ea0' target=_blank style='color:#2F92EE;'>#血压变化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88937, encryptionId=4cc58893ea0, topicName=血压变化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f1b531772449, createdName=ms1467340776200723, createdTime=Wed Oct 31 14:41:00 CST 2018, time=2018-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267846, encodeId=b91d126e8461a, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Tue Jun 12 11:41:00 CST 2018, time=2018-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1574859, encodeId=360115e4859e2, content=<a href='/topic/show?id=6d6210228935' target=_blank style='color:#2F92EE;'>#高原#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102289, encryptionId=6d6210228935, topicName=高原)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=687116029883, createdName=jmtang, createdTime=Tue Jun 12 11:41:00 CST 2018, time=2018-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323360, encodeId=362e32336006, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/6r91EF8BMOLCD55MqUYf0ibGeibzcwCxaSD5XqTv5sRrxxzV9TpHfN8fDaNYCt8Jay98QLKHyzBpkr1f4v2EIcDQ/132, createdBy=c24466863, createdName=liuchuan1982, createdTime=Mon Jun 11 21:14:25 CST 2018, time=2018-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323139, encodeId=669132313944, content=不错的文章值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sun Jun 10 22:34:50 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323134, encodeId=150c32313478, content=不错的文章值得拥有哦!, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Sun Jun 10 22:21:51 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323119, encodeId=2d413231198a, content=好文章.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Jun 10 21:41:44 CST 2018, time=2018-06-10, status=1, ipAttribution=)]
    2018-06-10 131****2916

    不错的文章值得推荐一下

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1822344, encodeId=83181822344a4, content=<a href='/topic/show?id=c4fa1026584a' target=_blank style='color:#2F92EE;'>#高血压人群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102658, encryptionId=c4fa1026584a, topicName=高血压人群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Fri Jul 27 10:41:00 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1709690, encodeId=87a91e09690e9, content=<a href='/topic/show?id=4cc58893ea0' target=_blank style='color:#2F92EE;'>#血压变化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88937, encryptionId=4cc58893ea0, topicName=血压变化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f1b531772449, createdName=ms1467340776200723, createdTime=Wed Oct 31 14:41:00 CST 2018, time=2018-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267846, encodeId=b91d126e8461a, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Tue Jun 12 11:41:00 CST 2018, time=2018-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1574859, encodeId=360115e4859e2, content=<a href='/topic/show?id=6d6210228935' target=_blank style='color:#2F92EE;'>#高原#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102289, encryptionId=6d6210228935, topicName=高原)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=687116029883, createdName=jmtang, createdTime=Tue Jun 12 11:41:00 CST 2018, time=2018-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323360, encodeId=362e32336006, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/6r91EF8BMOLCD55MqUYf0ibGeibzcwCxaSD5XqTv5sRrxxzV9TpHfN8fDaNYCt8Jay98QLKHyzBpkr1f4v2EIcDQ/132, createdBy=c24466863, createdName=liuchuan1982, createdTime=Mon Jun 11 21:14:25 CST 2018, time=2018-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323139, encodeId=669132313944, content=不错的文章值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sun Jun 10 22:34:50 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323134, encodeId=150c32313478, content=不错的文章值得拥有哦!, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Sun Jun 10 22:21:51 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323119, encodeId=2d413231198a, content=好文章.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Jun 10 21:41:44 CST 2018, time=2018-06-10, status=1, ipAttribution=)]
    2018-06-10 1e1b8538m79(暂无匿称)

    不错的文章值得拥有哦!

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1822344, encodeId=83181822344a4, content=<a href='/topic/show?id=c4fa1026584a' target=_blank style='color:#2F92EE;'>#高血压人群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102658, encryptionId=c4fa1026584a, topicName=高血压人群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Fri Jul 27 10:41:00 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1709690, encodeId=87a91e09690e9, content=<a href='/topic/show?id=4cc58893ea0' target=_blank style='color:#2F92EE;'>#血压变化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88937, encryptionId=4cc58893ea0, topicName=血压变化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f1b531772449, createdName=ms1467340776200723, createdTime=Wed Oct 31 14:41:00 CST 2018, time=2018-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267846, encodeId=b91d126e8461a, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Tue Jun 12 11:41:00 CST 2018, time=2018-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1574859, encodeId=360115e4859e2, content=<a href='/topic/show?id=6d6210228935' target=_blank style='color:#2F92EE;'>#高原#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102289, encryptionId=6d6210228935, topicName=高原)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=687116029883, createdName=jmtang, createdTime=Tue Jun 12 11:41:00 CST 2018, time=2018-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323360, encodeId=362e32336006, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/6r91EF8BMOLCD55MqUYf0ibGeibzcwCxaSD5XqTv5sRrxxzV9TpHfN8fDaNYCt8Jay98QLKHyzBpkr1f4v2EIcDQ/132, createdBy=c24466863, createdName=liuchuan1982, createdTime=Mon Jun 11 21:14:25 CST 2018, time=2018-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323139, encodeId=669132313944, content=不错的文章值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sun Jun 10 22:34:50 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323134, encodeId=150c32313478, content=不错的文章值得拥有哦!, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Sun Jun 10 22:21:51 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323119, encodeId=2d413231198a, content=好文章.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Jun 10 21:41:44 CST 2018, time=2018-06-10, status=1, ipAttribution=)]
    2018-06-10 1e0f8808m18(暂无匿称)

    好文章.学习了.

    0

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本研究的目的旨在评估接受右室流出道(RVOT)移植重建妇女的孕期预后结局。本研究纳入了196名18-50岁接受右室流出道(RVOT)移植重建的女性,并对其完全妊娠(孕期≥20周)的心脏、产科和胎儿的结局进行了评估。分析结果显示,有56名女性完成了89次完全妊娠,其中有84次(94.4%)的数据较完整,可分析。患者的平均年龄为29.6 ± 4.3岁,80名患者的纽约心功能分级是I或II。最常见的疾病

Eur Heart J:Ebstein畸形患者发生猝死的风险分析

心室功能不全或结构异常是已知的猝死(SD)风险因素。Ebstein畸形(EA)表现为左右心结构的异常,但其致猝死的预测因素尚未阐明。本研究的目的旨在评估EA患者出现SD的发病率和风险预测因素。本研究共纳入了近40年的968名EA患者(平均年龄25.3岁,男性占41.5%,79.8%为严重EA,18.6%存在旁路,0.74%植入有除颤器),并对其临床资料进行了全面回顾。分析结果显示,患者出生后10年

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既往研究显示钠葡萄糖协同转运蛋白-2抑制剂(SGLT-2i)可以降低2型糖尿病(T2D)患者发生心血管疾病的风险,但其仅局限于心衰和死亡风险,且人群局限于欧美人群。本研究的目的旨在评估SGLT-2i对6个国家人群的更广泛的心血管疾病风险的影响。本研究纳入了韩国、日本、新加坡、以色列、澳大利亚和加拿大等六个国家使用SGLT-2i和其他降血糖药(oGLDs)的T2D患者,并根据倾向性评分进行了1:1匹

先天性左心室-冠状静脉窦瘘一例

患者男性,78岁,因“反复胸闷、胸痛10年”于2015年11月20日入院。入院前10年,患者开始逐渐出现活动后胸闷、胸痛、无心悸,无咳嗽咳痰,无头晕黑矇,无反酸烧心等不适。患者在当地医院多次行心电图检查均提示“前壁心肌缺血”,给予硝酸酯类治疗后,患者自觉症状有所好转,但仍时有发作。入院前1周,患者胸痛症状再发,并伴有心悸,为求治疗患者转成都中医药大学附属医院就诊,入院查体提示心脏相对浊音界向右扩大

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本研究的目的旨在评估自从引入高敏心脏肌钙蛋白T(hs-cTnT)后,对首次心梗的诊断率和预后带来了什么影响。本研究纳入了87879例2009至2013年来自瑞典国家数据库中的所有首发心梗的患者,在研究期间,通过心脏肌钙蛋白诊断出的心梗患者为47133例,而通过hs-cTnT诊断出的心梗患者为40746例,从引入hs-cTnT后,心梗的发病率增加了5%(95% CI: 0%-10%),经过平均3.9