CARDIOVASC DIABETOL:胎球蛋白A可以预测糖尿病血管并发症风险!

2022-01-24 MedSci原创 MedSci原创

不适当的低胎球蛋白-A水平可能与2型糖尿病微血管疾病的发生有关。

Fetuin-A(胎球蛋白)具有防止血管钙化的能力,此外,它与代谢功能障碍、胰岛素抵抗和糖尿病的发病风险有关,但胎球蛋白A是否与糖尿病患者发生血管并发症的风险有关目前尚不清楚。本研究的目的是调查血浆胎球蛋白A是否与糖尿病的并发症风险相关。

有587名患有2型糖尿病且无微血管和大血管疾病的参与者接受了调查,中位随访时间为13年。在糖尿病诊断前4年测量了血浆胎球蛋白A。使用Cox回归评估基线胎球蛋白A与并发症风险之间的关联。

在多变量模型中,胎球蛋白-A与发生总并发症和微血管并发症呈线性负相关,每标准差(SD)增加的风险比(HR, 95% CI):总计0.86(0.74;0.99),微血管并发症为0.84,大血管并发症为0.92。在对心脏代谢血浆生物标志物(包括甘油三酯和高密度脂蛋白)进行额外调整后,相关性略有减弱:总体为0.88,微血管并发症为0.85,大血管并发症为0.95。没有观察到性别间的相互作用。

胎球蛋白A浓度与糖尿病相关血管并发症风险的关联。根据基线胎球蛋白A浓度显示剂量反应-曲线形状图:总血管 (A)、微血管 (B) 和大血管(C)并发症的风险比(实线)和相应的95% CI(阴影面积)。

简而言之,在T2D患者中,诊断前较低的胎球蛋白-A水平与较高的血管并发症风险相关,尤其是微血管并发症,与已确定的心脏代谢危险因素无关。不适当的低胎球蛋白-A水平可能与2型糖尿病微血管疾病的发生有关。

参考文献:Birukov, A., Polemiti, E., Jäger, S. et al. Fetuin-A and risk of diabetes-related vascular complications: a prospective study. Cardiovasc Diabetol 21, 6 (2022). https://doi.org/10.1186/s12933-021-01439-8

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    2022-07-28 quxin068
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    2022-05-01 丁鹏鹏
  5. [GetPortalCommentsPageByObjectIdResponse(id=1939306, encodeId=d67f193930632, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Thu Jul 28 08:45:25 CST 2022, time=2022-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761827, encodeId=e5d61e6182792, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Mon Dec 19 14:45:25 CST 2022, time=2022-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640038, encodeId=7385164003849, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri Dec 09 13:45:25 CST 2022, time=2022-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1758415, encodeId=a7961e584157f, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Sun May 01 17:45:25 CST 2022, time=2022-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035271, encodeId=40fa20352e1a7, content=<a href='/topic/show?id=5a426866eae' target=_blank style='color:#2F92EE;'>#球蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68667, encryptionId=5a426866eae, topicName=球蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2317301, createdName=xzw113, createdTime=Tue Aug 30 08:45:25 CST 2022, time=2022-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1187775, encodeId=996d118e7758e, content=谢谢分享,好东西!, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d0be2111725, createdName=萌宝嘟嘟, createdTime=Mon Jan 24 18:51:28 CST 2022, time=2022-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1545384, encodeId=a2891545384af, content=<a href='/topic/show?id=a803896303f' target=_blank style='color:#2F92EE;'>#血管并发症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89630, encryptionId=a803896303f, topicName=血管并发症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b67913724176, createdName=ms3892185887221420, createdTime=Sat Jan 22 12:45:25 CST 2022, time=2022-01-22, status=1, ipAttribution=)]
    2022-08-30 xzw113
  6. [GetPortalCommentsPageByObjectIdResponse(id=1939306, encodeId=d67f193930632, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Thu Jul 28 08:45:25 CST 2022, time=2022-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761827, encodeId=e5d61e6182792, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Mon Dec 19 14:45:25 CST 2022, time=2022-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640038, encodeId=7385164003849, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri Dec 09 13:45:25 CST 2022, time=2022-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1758415, encodeId=a7961e584157f, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Sun May 01 17:45:25 CST 2022, time=2022-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035271, encodeId=40fa20352e1a7, content=<a href='/topic/show?id=5a426866eae' target=_blank style='color:#2F92EE;'>#球蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68667, encryptionId=5a426866eae, topicName=球蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2317301, createdName=xzw113, createdTime=Tue Aug 30 08:45:25 CST 2022, time=2022-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1187775, encodeId=996d118e7758e, content=谢谢分享,好东西!, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d0be2111725, createdName=萌宝嘟嘟, createdTime=Mon Jan 24 18:51:28 CST 2022, time=2022-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1545384, encodeId=a2891545384af, content=<a href='/topic/show?id=a803896303f' target=_blank style='color:#2F92EE;'>#血管并发症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89630, encryptionId=a803896303f, topicName=血管并发症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b67913724176, createdName=ms3892185887221420, createdTime=Sat Jan 22 12:45:25 CST 2022, time=2022-01-22, status=1, ipAttribution=)]
    2022-01-24 萌宝嘟嘟

    谢谢分享,好东西!

    0

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