Cancer Res:aP2-Cre介导等位基因Dicer1缺失导致血管肉瘤发生

2017-11-26 Emma MedSci原创

血管肉瘤又称恶性血管内皮细胞瘤,是一种罕见的恶性内皮细胞瘤,发生于皮肤、软组织、乳腺、骨、肝和其他内脏,且预后极差。

血管肉瘤又称恶性血管内皮细胞瘤,是一种罕见的恶性内皮细胞瘤,发生于皮肤、软组织、乳腺、骨、肝和其他内脏,且预后极差。关于血管肉瘤疾病的分子驱动因素以及治疗策略进展仍然有限。研究人员试图探究导致血管肉瘤发生的内在机制。

Dicer1是以miRNA生物发生为中心的RNase III内切核糖核酸酶,它能以ATP依赖的方式逐步切割由外源导入或者由转基因,病毒感染等各种方式引入的双链RNA,切割将RNA降解为19-21bp的双链RNAs。Dicer1在生殖细胞中突变会导致癌症倾向综合征,且与多种肿瘤类型的风险增加有关。

研究人员研究发现,aP2-Cre介导等位基因Dicer1缺失,能够驱动侵入性和转移性血管肉瘤,它不同于其他基因工程的癌基因或肿瘤抑制丧失。aP2-Cre中的血管肉瘤以及Dicer1Flox/-小鼠模型在组织学和基因学上类似于人血管肉瘤,在小鼠和人血管肉瘤中均发现miR-23的靶基因包括致癌基因Ccnd1以及促进侵袭和转移的Adam19,Plau和Wsb1的富集。该研究建立了一个深入探究血管肉瘤的发展和转移的动物模型,并表明Dicer1可以作为传统的功能丧失的肿瘤抑制基因起作用,aP2-Cre介导等位基因Dicer1损失导致血管肉瘤发生。

原始出处:
Hanna JA, et al. Biallelic Dicer1 Loss Mediated by aP2-Cre Drives Angiosarcoma. Cancer Res. 2017 Nov 15;77(22):6109-6118. doi: 10.1158/0008-5472.CAN-17-1262. Epub 2017 Sep 15.

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    2018-02-17 chenwq08
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    2018-06-05 30397604
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encryptionId=e0a9593596, topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Tue Jan 16 07:13:00 CST 2018, time=2018-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779988, encodeId=fb871e799883d, content=<a href='/topic/show?id=694d26193d' target=_blank style='color:#2F92EE;'>#aP2-Cre#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2619, encryptionId=694d26193d, topicName=aP2-Cre)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=da20314, createdName=lfcmxl, createdTime=Thu Jul 26 11:13:00 CST 2018, time=2018-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=267740, encodeId=c46726e74086, content=介导等位基因的缺失., beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Dec 08 07:31:41 CST 2017, time=2017-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1484144, encodeId=48161484144cc, content=<a href='/topic/show?id=d2fbe588905' target=_blank style='color:#2F92EE;'>#等位基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75889, encryptionId=d2fbe588905, topicName=等位基因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=68e17955541, createdName=luckyshitiancai_42705686, createdTime=Tue Nov 28 01:13:00 CST 2017, time=2017-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1581468, encodeId=9a7015814686e, content=<a href='/topic/show?id=2bc1519579' target=_blank style='color:#2F92EE;'>#CRE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5195, encryptionId=2bc1519579, topicName=CRE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4ca216802819, createdName=HinsMax, createdTime=Tue Nov 28 01:13:00 CST 2017, time=2017-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264882, encodeId=535d26488263, content=了解了解.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Nov 27 22:44:56 CST 2017, time=2017-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264546, encodeId=f0b826454688, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sun Nov 26 18:19:11 CST 2017, time=2017-11-26, status=1, ipAttribution=)]
    2018-01-16 jeanqiuqiu
  5. [GetPortalCommentsPageByObjectIdResponse(id=1997045, encodeId=0e5c199e045ac, content=<a href='/topic/show?id=f97d934e3c' target=_blank style='color:#2F92EE;'>#ICER#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9347, encryptionId=f97d934e3c, topicName=ICER)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=365d170, createdName=chenwq08, createdTime=Sat Feb 17 13:13:00 CST 2018, time=2018-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1632972, encodeId=943616329e2ea, content=<a href='/topic/show?id=c49789e6867' target=_blank style='color:#2F92EE;'>#血管肉瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89768, encryptionId=c49789e6867, topicName=血管肉瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b44321973193, 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style='color:#2F92EE;'>#CRE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5195, encryptionId=2bc1519579, topicName=CRE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4ca216802819, createdName=HinsMax, createdTime=Tue Nov 28 01:13:00 CST 2017, time=2017-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264882, encodeId=535d26488263, content=了解了解.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Nov 27 22:44:56 CST 2017, time=2017-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264546, encodeId=f0b826454688, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sun Nov 26 18:19:11 CST 2017, time=2017-11-26, status=1, ipAttribution=)]
    2018-07-26 lfcmxl
  6. [GetPortalCommentsPageByObjectIdResponse(id=1997045, encodeId=0e5c199e045ac, content=<a href='/topic/show?id=f97d934e3c' target=_blank style='color:#2F92EE;'>#ICER#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9347, encryptionId=f97d934e3c, topicName=ICER)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=365d170, createdName=chenwq08, createdTime=Sat Feb 17 13:13:00 CST 2018, time=2018-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1632972, encodeId=943616329e2ea, content=<a href='/topic/show?id=c49789e6867' target=_blank style='color:#2F92EE;'>#血管肉瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89768, encryptionId=c49789e6867, topicName=血管肉瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b44321973193, 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style='color:#2F92EE;'>#CRE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5195, encryptionId=2bc1519579, topicName=CRE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4ca216802819, createdName=HinsMax, createdTime=Tue Nov 28 01:13:00 CST 2017, time=2017-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264882, encodeId=535d26488263, content=了解了解.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Nov 27 22:44:56 CST 2017, time=2017-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264546, encodeId=f0b826454688, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sun Nov 26 18:19:11 CST 2017, time=2017-11-26, status=1, ipAttribution=)]
    2017-12-08 jyzxjiangqin

    介导等位基因的缺失.

    0

  7. 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style='color:#2F92EE;'>#CRE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5195, encryptionId=2bc1519579, topicName=CRE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4ca216802819, createdName=HinsMax, createdTime=Tue Nov 28 01:13:00 CST 2017, time=2017-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264882, encodeId=535d26488263, content=了解了解.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Nov 27 22:44:56 CST 2017, time=2017-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264546, encodeId=f0b826454688, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sun Nov 26 18:19:11 CST 2017, time=2017-11-26, status=1, ipAttribution=)]
  8. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Dec 08 07:31:41 CST 2017, time=2017-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1484144, encodeId=48161484144cc, content=<a href='/topic/show?id=d2fbe588905' target=_blank style='color:#2F92EE;'>#等位基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75889, encryptionId=d2fbe588905, topicName=等位基因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=68e17955541, createdName=luckyshitiancai_42705686, createdTime=Tue Nov 28 01:13:00 CST 2017, time=2017-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1581468, encodeId=9a7015814686e, content=<a href='/topic/show?id=2bc1519579' target=_blank style='color:#2F92EE;'>#CRE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5195, encryptionId=2bc1519579, topicName=CRE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4ca216802819, createdName=HinsMax, createdTime=Tue Nov 28 01:13:00 CST 2017, time=2017-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264882, encodeId=535d26488263, content=了解了解.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Nov 27 22:44:56 CST 2017, time=2017-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264546, encodeId=f0b826454688, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sun Nov 26 18:19:11 CST 2017, time=2017-11-26, status=1, ipAttribution=)]
    2017-11-28 HinsMax
  9. [GetPortalCommentsPageByObjectIdResponse(id=1997045, encodeId=0e5c199e045ac, content=<a href='/topic/show?id=f97d934e3c' target=_blank style='color:#2F92EE;'>#ICER#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9347, encryptionId=f97d934e3c, topicName=ICER)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=365d170, createdName=chenwq08, createdTime=Sat Feb 17 13:13:00 CST 2018, time=2018-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1632972, encodeId=943616329e2ea, content=<a href='/topic/show?id=c49789e6867' target=_blank style='color:#2F92EE;'>#血管肉瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89768, encryptionId=c49789e6867, topicName=血管肉瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b44321973193, createdName=gwc390, createdTime=Fri May 04 21:13:00 CST 2018, time=2018-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1784189, encodeId=40f41e8418926, content=<a href='/topic/show?id=c4c2593e8b' target=_blank style='color:#2F92EE;'>#Dicer1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5937, encryptionId=c4c2593e8b, topicName=Dicer1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Tue Jun 05 10:13:00 CST 2018, time=2018-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1858834, encodeId=62be18588344c, content=<a href='/topic/show?id=e0a9593596' target=_blank style='color:#2F92EE;'>#DIC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5935, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Dec 08 07:31:41 CST 2017, time=2017-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1484144, encodeId=48161484144cc, content=<a href='/topic/show?id=d2fbe588905' target=_blank style='color:#2F92EE;'>#等位基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75889, encryptionId=d2fbe588905, topicName=等位基因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=68e17955541, createdName=luckyshitiancai_42705686, createdTime=Tue Nov 28 01:13:00 CST 2017, time=2017-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1581468, encodeId=9a7015814686e, content=<a href='/topic/show?id=2bc1519579' target=_blank style='color:#2F92EE;'>#CRE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5195, encryptionId=2bc1519579, topicName=CRE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4ca216802819, createdName=HinsMax, createdTime=Tue Nov 28 01:13:00 CST 2017, time=2017-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264882, encodeId=535d26488263, content=了解了解.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Nov 27 22:44:56 CST 2017, time=2017-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264546, encodeId=f0b826454688, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sun Nov 26 18:19:11 CST 2017, time=2017-11-26, status=1, ipAttribution=)]
    2017-11-27 1dd8c52fm63(暂无匿称)

    了解了解.继续关注

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1997045, encodeId=0e5c199e045ac, content=<a href='/topic/show?id=f97d934e3c' target=_blank style='color:#2F92EE;'>#ICER#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9347, encryptionId=f97d934e3c, topicName=ICER)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=365d170, createdName=chenwq08, createdTime=Sat Feb 17 13:13:00 CST 2018, time=2018-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1632972, encodeId=943616329e2ea, content=<a href='/topic/show?id=c49789e6867' target=_blank style='color:#2F92EE;'>#血管肉瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89768, encryptionId=c49789e6867, topicName=血管肉瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b44321973193, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Dec 08 07:31:41 CST 2017, time=2017-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1484144, encodeId=48161484144cc, content=<a href='/topic/show?id=d2fbe588905' target=_blank style='color:#2F92EE;'>#等位基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75889, encryptionId=d2fbe588905, topicName=等位基因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=68e17955541, createdName=luckyshitiancai_42705686, createdTime=Tue Nov 28 01:13:00 CST 2017, time=2017-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1581468, encodeId=9a7015814686e, content=<a href='/topic/show?id=2bc1519579' target=_blank style='color:#2F92EE;'>#CRE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5195, encryptionId=2bc1519579, topicName=CRE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4ca216802819, createdName=HinsMax, createdTime=Tue Nov 28 01:13:00 CST 2017, time=2017-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264882, encodeId=535d26488263, content=了解了解.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Nov 27 22:44:56 CST 2017, time=2017-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264546, encodeId=f0b826454688, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sun Nov 26 18:19:11 CST 2017, time=2017-11-26, status=1, ipAttribution=)]
    2017-11-26 1dd8c52fm63(暂无匿称)

    学习学习.继续关注

    0

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