Arthritis Rheumatol:膳食和补充Ω-3多不饱和脂肪酸对复发性痛风发作风险的影响

2019-03-26 xiangting MedSci原创

当调整总嘌呤摄入量后,吃富含膳食n-3 PUFA的鱼类与复发性痛风发作的风险较低相关。

这项研究旨在确定Ω-3多不饱和脂肪酸(n-3 PUFA)消费(膳食或补充)与痛风发作风险之间的关联。

研究人员使用波士顿大学在线痛风研究的数据,从2003年至2012年开展了一项基于互联网的病例交叉研究。参与者在痛风发作期间(危险期)和无痛风发作期间(对照期)完成过去48小时内暴露情况(包括补充剂和饮食)的问卷调查。使用条件logistic回归检验,调整总嘌呤摄入量、利尿剂使用和其他降尿酸或发作预防性药物(别嘌呤醇、非甾体类抗炎药、秋水仙碱)后,分析了自我报告的富含n-3 PUFA补充剂和鱼类摄入与复发性痛风发作风险的关联。

在724名参与者中,85%符合1977年急性痛风的初步ACR分类标准。在过去48小时内,22%的参与者报告有某种形式的n-3 PUFA消费(补充剂:4.6%;膳食脂肪鱼类:19%)。所有3种补充剂类型的调整后比值比(aOR)为1.01(95%CI,0.63-1.60; p=0.98),对于≥2种n-3 PUFA丰富的鱼类, aOR为0.74(95%CI,0.54-0.99; p=0.04)。

当调整总嘌呤摄入量后,吃富含膳食n-3 PUFA的鱼类与复发性痛风发作的风险较低相关,而以自我导向方式单独补充n-3 PUFA,与复发性痛风发作的风险较低不相关。摄取特定来源和足够剂量的n-3 PUFA可预防痛风,需要在有充分动力的临床试验中进一步研究。

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  8. 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    2019-03-28 zhaojie88
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    2019-03-28 zhaojie88
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