SCI REP:平均血小板体积对放化疗局部晚期非小细胞肺癌的预后意义

2019-03-09 不详 MedSci原创

平均血小板体积(MPV)在恶性肿瘤患者中会明显改变。本研究的目的是研究MPV与局部晚期(IIIA / B期)不能手术的非小细胞肺癌(NSCLC)患者的总生存(OS)的影响。

平均血小板体积(MPV)在恶性肿瘤患者中会明显改变。本研究的目的是研究MPV与局部晚期(IIIA / B期)不能手术的非小细胞肺癌NSCLC)患者的总生存(OS)的影响。

本项研究为回顾性研究,纳入了115例因局部晚期IIIA / B期NSCLC而接受顺铂+依托泊苷治疗的伴随放化疗(CCRT)的患者。其中男性110例(95.7%),女性5例(4.2%)。患者的平均年龄为61.3±10.4(22-82)岁。AUC为0.746(95%CI :0.659-0.833),(p <0.001)。截断值:MPV> 9 fL,灵敏度为74.4%,特异性为72.0%。研究人员发现治疗前MPV减少是服用CCRT的NSCLC患者生存的独立危险因素。作为常规全血细胞计数小组的一部分,MPV可能是最简单的测量工具之一,作为在局部晚期NSCLC中存活的独立预后标志物,通过分析ECOG表现评分发现总血小板计数和MPV是影响存活的最重要的独立因素(分别为p <0.001,p = 0.008,和p = 0.034)。

本项研究发现治疗前MPV减少是服用CCRT的NSCLC患者生存的独立危险因素。作为常规全血细胞计数小组的一部分,MPV可能是最简单的测量工具之一,作为在局部晚期NSCLC中存活的独立预后标志物。

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    2019-03-11 yzh399
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    2019-03-11 chg122
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