Diabetologia:全国糖尿病患者队列中下肢截肢的风险

2018-04-12 MedSci MedSci原创

下肢截肢是糖尿病的严重并发症。了解因人口亚群关系截肢风险如何不同,对于指导预防策略而言至关重要。近日,国际杂志 《Diabetologia》上在线发表一项关于全国糖尿病患者队列中下肢截肢的风险的研究。在这项研究中,研究人员描述了影响新西兰整个糖尿病人群截肢风险的因素。 全国共有217207名糖尿病患者接受了随访从2010年至2013年底的下肢截肢情况以及2014年的死亡率的调查。研究人员使

下肢截肢是糖尿病的严重并发症。了解因人口亚群关系截肢风险如何不同,对于指导预防策略而言至关重要。近日,国际杂志 《Diabetologia》上在线发表一项关于全国糖尿病患者队列中下肢截肢的风险的研究。在这项研究中,研究人员描述了影响新西兰整个糖尿病人群截肢风险的因素。 全国共有217207名糖尿病患者接受了随访从2010年至2013年底的下肢截肢情况以及2014年的死亡率的调查。研究人员使用ICD-10代码来定义住院病人的下肢截肢。并采用Cox比例风险模型描述随访期间截肢的相对危险。 研究发现随访期间,共有784人(3.6 / 1000人)接受了大(上踝)下肢截肢,而1217(5.6 / 1000)人接受了小(踝关节以下)截肢。男性和女性大小的的截肢的风险分别是男性高于女性39%和77%(校正后的HR:大截肢1.39,95%CI 1.20,1.61;小截肢1.77,95%CI 1.56,2.00)。与欧洲/其他糖尿病人群相比,土著毛利人的膝上截肢风险增加65%(HR 1.65,95%CI 1.37,1.97)。截肢风险随着合并症负担的增加而增加,并且外周血管疾病赋予所有合并症的最大独立

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