Am J Clin Nutr:与高脂牛奶相比,食用低脂牛奶并不会降低儿童日后肥胖和心脏代谢疾病风险

2022-04-24 Nebula MedSci原创

该研究结果不支持当前主流的指南,即食用低脂牛奶以降低日后肥胖和不良心脏代谢结果的风险

乳制品为儿童的生长和骨骼健康提供了丰富的营养来源;但是,乳制品中的脂肪会导致体重多大程度地增加尚未明确,而且既往研究提供了关于儿童饮用牛奶与随后肥胖之间相关性的相互矛盾的证据。多个国家的指南建议,从两岁开始从全脂牛奶(乳脂含量 3.25%)逐渐过渡到低脂牛奶(0-1%)。

本研究旨在评估儿童早期牛奶摄入频率和脂肪含量与青少年早期肥胖和心脏代谢风险的相关性。

研究人员分析了从Viva项目中收集的796名儿童的前瞻性数据。受试者通过食物频率问卷报告了在儿童早期(平均3.2岁)饮用牛奶的频率(次/天)和脂肪含量(全脂 3.25%或2%;低脂 1%或脱脂)。研究人员测量了受试者青春期早期(平均13.2岁)的肥胖和心脏代谢指标;通过多变量回归分析了儿童早期牛奶摄入频率和脂肪含量与青少年早期肥胖和心脏代谢风险的相关性,并根据基线父母和儿童社会人口学、人体测量和饮食因素进行了调整。


儿童早期食用牛奶脂肪含量与BMI z评分变化的相关性

在儿童早期,平均牛奶摄入量为2.3次/天 (标准差为1.2),63%的儿童主要饮用高脂牛奶。儿童早期BMI z-评分 (BMIz)与儿童早期饮用牛奶的脂肪含量呈负相关。在调整了基线父母和儿童因素后,与低脂牛奶相比,儿童早期摄入高脂牛奶与青春期早期更少的肥胖相关(OR 0.60)。


儿童早期食用牛奶的频率和脂肪含量与日后肥胖的相关性

与低脂牛奶相比,儿童早期食用高脂牛奶与不良的心脏代谢结局无关。此外,儿童早期饮用牛奶的频率与青少年早期的肥胖或心脏代谢风险也无关。

综上,儿童早期食用高脂牛奶与10年后的肥胖或不良心脏代谢健康没有关联。该研究结果并不支持当前主流的指南,即食用低脂牛奶以降低日后肥胖和不良心脏代谢结果的风险。

原始出处:

McGovern Caitriona,Rifas-Shiman Sheryl L,Switkowski Karen M et al. Association of cow's milk intake in early childhood with adiposity and cardiometabolic risk in early adolescence.[J] .Am J Clin Nutr, 2022, https://doi.org/10.1093/ajcn/nqac103

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1214451, encodeId=232c1214451be, content=跟自己的想法不太一样,但是科学结论面前,真的是受教了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=53af8104160, createdName=ms5000000791850947, createdTime=Tue Apr 26 12:42:49 CST 2022, time=2022-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1214116, encodeId=8af5121411656, content=儿童生长发育期确实应该提倡每日服用适量全职纯牛乳, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=38c05609551, createdName=ms8000001104582032, createdTime=Mon Apr 25 14:44:19 CST 2022, time=2022-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1213875, encodeId=b53c12138e527, content=好文章,值得一读。, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Sun Apr 24 12:40:03 CST 2022, time=2022-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1337252, encodeId=2b13133e2525d, content=<a href='/topic/show?id=f4c251404aa' target=_blank style='color:#2F92EE;'>#心脏代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51404, encryptionId=f4c251404aa, topicName=心脏代谢)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIUEDhSibBFt8TicgFCCSBtW10SxVJicDpibTCucns8L1YaiaKpibWOkv8hYpJ0LeTVUH1Ab4sfica9bxiccA/132, createdBy=dd282500126, createdName=ms3830150583600765, createdTime=Sun Apr 24 12:25:37 CST 2022, time=2022-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402024, encodeId=c7451402024bb, content=<a href='/topic/show?id=193025463d8' target=_blank style='color:#2F92EE;'>#代谢疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25463, encryptionId=193025463d8, topicName=代谢疾病)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/F9591315BE4091482318EFFCD39C9D08/100, createdBy=bf9f2374681, createdName=windight, createdTime=Sun Apr 24 12:25:37 CST 2022, time=2022-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473334, encodeId=3d8c14e3334a5, content=<a href='/topic/show?id=862be0746bc' target=_blank style='color:#2F92EE;'>#疾病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70746, encryptionId=862be0746bc, topicName=疾病风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c757221906, createdName=花花1368, createdTime=Sun Apr 24 12:25:37 CST 2022, time=2022-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1574688, encodeId=388115e468871, content=<a href='/topic/show?id=9b56102616bb' target=_blank style='color:#2F92EE;'>#高脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102616, encryptionId=9b56102616bb, topicName=高脂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c3b716021149, createdName=pcw111, createdTime=Sun Apr 24 12:25:37 CST 2022, time=2022-04-24, status=1, ipAttribution=)]
    2022-04-26 ms5000000791850947

    跟自己的想法不太一样,但是科学结论面前,真的是受教了

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1214451, encodeId=232c1214451be, content=跟自己的想法不太一样,但是科学结论面前,真的是受教了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=53af8104160, createdName=ms5000000791850947, createdTime=Tue Apr 26 12:42:49 CST 2022, time=2022-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1214116, encodeId=8af5121411656, content=儿童生长发育期确实应该提倡每日服用适量全职纯牛乳, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=38c05609551, createdName=ms8000001104582032, createdTime=Mon Apr 25 14:44:19 CST 2022, time=2022-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1213875, encodeId=b53c12138e527, content=好文章,值得一读。, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Sun Apr 24 12:40:03 CST 2022, time=2022-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1337252, encodeId=2b13133e2525d, content=<a href='/topic/show?id=f4c251404aa' target=_blank style='color:#2F92EE;'>#心脏代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51404, encryptionId=f4c251404aa, topicName=心脏代谢)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIUEDhSibBFt8TicgFCCSBtW10SxVJicDpibTCucns8L1YaiaKpibWOkv8hYpJ0LeTVUH1Ab4sfica9bxiccA/132, createdBy=dd282500126, createdName=ms3830150583600765, createdTime=Sun Apr 24 12:25:37 CST 2022, time=2022-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402024, encodeId=c7451402024bb, content=<a href='/topic/show?id=193025463d8' target=_blank style='color:#2F92EE;'>#代谢疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25463, encryptionId=193025463d8, topicName=代谢疾病)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/F9591315BE4091482318EFFCD39C9D08/100, createdBy=bf9f2374681, createdName=windight, createdTime=Sun Apr 24 12:25:37 CST 2022, time=2022-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473334, encodeId=3d8c14e3334a5, content=<a href='/topic/show?id=862be0746bc' target=_blank style='color:#2F92EE;'>#疾病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70746, encryptionId=862be0746bc, topicName=疾病风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c757221906, createdName=花花1368, createdTime=Sun Apr 24 12:25:37 CST 2022, time=2022-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1574688, encodeId=388115e468871, content=<a href='/topic/show?id=9b56102616bb' target=_blank style='color:#2F92EE;'>#高脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102616, encryptionId=9b56102616bb, topicName=高脂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c3b716021149, createdName=pcw111, createdTime=Sun Apr 24 12:25:37 CST 2022, time=2022-04-24, status=1, ipAttribution=)]
    2022-04-25 ms8000001104582032

    儿童生长发育期确实应该提倡每日服用适量全职纯牛乳

    0

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    2022-04-24 yangchou

    好文章,值得一读。

    0

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  6. [GetPortalCommentsPageByObjectIdResponse(id=1214451, encodeId=232c1214451be, content=跟自己的想法不太一样,但是科学结论面前,真的是受教了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=53af8104160, createdName=ms5000000791850947, createdTime=Tue Apr 26 12:42:49 CST 2022, time=2022-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1214116, encodeId=8af5121411656, content=儿童生长发育期确实应该提倡每日服用适量全职纯牛乳, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=38c05609551, createdName=ms8000001104582032, createdTime=Mon Apr 25 14:44:19 CST 2022, time=2022-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1213875, encodeId=b53c12138e527, content=好文章,值得一读。, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Sun Apr 24 12:40:03 CST 2022, time=2022-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1337252, encodeId=2b13133e2525d, content=<a href='/topic/show?id=f4c251404aa' target=_blank style='color:#2F92EE;'>#心脏代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51404, encryptionId=f4c251404aa, topicName=心脏代谢)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIUEDhSibBFt8TicgFCCSBtW10SxVJicDpibTCucns8L1YaiaKpibWOkv8hYpJ0LeTVUH1Ab4sfica9bxiccA/132, createdBy=dd282500126, createdName=ms3830150583600765, createdTime=Sun Apr 24 12:25:37 CST 2022, time=2022-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402024, encodeId=c7451402024bb, content=<a href='/topic/show?id=193025463d8' target=_blank style='color:#2F92EE;'>#代谢疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25463, encryptionId=193025463d8, topicName=代谢疾病)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/F9591315BE4091482318EFFCD39C9D08/100, createdBy=bf9f2374681, createdName=windight, createdTime=Sun Apr 24 12:25:37 CST 2022, time=2022-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473334, encodeId=3d8c14e3334a5, content=<a href='/topic/show?id=862be0746bc' target=_blank style='color:#2F92EE;'>#疾病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70746, encryptionId=862be0746bc, topicName=疾病风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c757221906, createdName=花花1368, createdTime=Sun Apr 24 12:25:37 CST 2022, time=2022-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1574688, encodeId=388115e468871, content=<a href='/topic/show?id=9b56102616bb' target=_blank style='color:#2F92EE;'>#高脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102616, encryptionId=9b56102616bb, topicName=高脂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c3b716021149, createdName=pcw111, createdTime=Sun Apr 24 12:25:37 CST 2022, time=2022-04-24, status=1, ipAttribution=)]
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    2022-04-24 pcw111

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