JAHA:心肺适能与首次急性心肌梗死风险

2019-04-17 xing.T 网络

由此可见,eCRF与女性AMI事件的风险呈负相关,而与男性无关。该研究的数据表明,高eCRF可能在降低AMI风险方面具有实质性益处。因此,有必要更加关注eCRF作为中年和老年人的心血管疾病的风险标记。

大多数评估心肺适能(CRF)作为血管危险因素的研究使用血管死亡率而不是心血管疾病事件作为主要终点,并且通常不包含女性。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,该研究的目的是估计的CRF(eCRF)与首次急性心肌梗死(AMI)风险之间的关系。

研究人员纳入了来自HUNT研究(Nord-Trøndelag健康研究)的26163名参与者(51.5%为女性),平均年龄为55.7岁,基线时无心血管疾病。基线eCRF分为三分位数。AMI来自挪威死因登记处的医院记录和死亡。研究人员使用精细和灰色回归模型来估计AMI的亚分布风险比(SHR),从而计算死亡的竞争风险。

在平均(范围)随访13(0.02-15.40)年(347462人次每年)期间,研究人员记录了1566例AMI事件。在完全调整的模型中,与最低三分位的男性相比,2个较高eCRF的男性AMI的SHR分别降低4%(SHR:0.96,95%CI:0.83-1.11)和10%(SHR:0.90,95%CI:0.77-1.05)。女性的相应数字为12%(SHR:0.88,95%CI:0.72-1.08)和25%(SHR:0.75,95%CI:0.60-0.95)。 

由此可见,eCRF与女性AMI事件的风险呈负相关,而与男性无关。该研究的数据表明,高eCRF可能在降低AMI风险方面具有实质性益处。因此,有必要更加关注eCRF作为中年和老年人的心血管疾病的风险标记。 

原始出处:

Rajesh Shigdel.et al.Cardiorespiratory Fitness and the Risk of First Acute Myocardial Infarction: The HUNT Study.JAHA.2019.https://doi.org/10.1161/JAHA.118.010293

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    2020-03-12 aids222
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    2019-04-23 清风拂面

    谢谢分享学习

    0

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    2019-04-19 清风拂面

    谢谢分享学习

    0

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    2019-04-19 仁心济世
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    2019-04-17 329523732

    不错

    0

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