JAHA:甲基苯丙胺相关心血管疾病的结局

2022-08-02 MedSci原创 MedSci原创

与酒精和可卡因相比,使用甲基苯丙胺有类似程度的心血管疾病风险。预防和治疗的重点应该是那些患有慢性肾病、高血压和精神障碍的个体。

甲基苯丙胺滥用影响到全世界2700万人,并与心血管疾病有关;然而,甲基苯丙胺使用者心血管疾病的危险因素还没有得到很好的研究。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员分析了2005年至2011年期间加州的住院患者,数据来源于“医疗成本与利用项目”数据库。研究人员分析了甲基苯丙胺使用与CVD(肺动脉高压、心力衰竭、卒中心肌梗死)之间的关系。

在参与医疗成本与利用项目的20249026名受试者中,66199名受试者使用了甲基苯丙胺(平均随访时间为4.58年)。与不使用甲基苯丙胺的个体相比,使用甲基苯丙胺的受试者更有可能是年轻人(33岁 vs. 45岁)、男性(63.3% vs. 44.4%)、吸烟、滥用酒精、抑郁和焦虑。

使用甲基苯丙胺与心力衰竭(危险比[HR]为1.53[95%CI为1.45-1.62])和肺动脉高压(HR为1.42[95%CI为1.26-1.60])的发生相关。在甲基苯丙胺使用者中,男性(HR为1.73[95%CI为1.37-2.18])与心肌梗死相关。慢性肾病(HR为2.38[95%CI为1.74-3.25])和高血压(HR为2.26[95%CI为2.03-2.51])是甲基苯丙胺使用者发生CVD的危险因素。与不使用甲基苯丙胺相比,使用甲基苯丙胺与心血管疾病显著增加32%相关,滥用酒精与心血管疾病显著增加28%相关,使用可卡因与心血管疾病显著增加47%相关。

由此可见,与酒精和可卡因相比,使用甲基苯丙胺有类似程度的心血管疾病风险。预防和治疗的重点应该是那些患有慢性肾病、高血压和精神障碍的个体。

原始出处:

Lara Curran.et al.Clinical Correlates and Outcomes of Methamphetamine‐Associated Cardiovascular Diseases in Hospitalized Patients in California.JAHA.2022.https://www.ahajournals.org/doi/full/10.1161/JAHA.121.023663

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    2022-08-03 zhaohui6731
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