Obstet Gynecol:子痫前期孕妇更容易发生视网膜疾病

2016-12-08 haofan MedSci原创

子痫前期,特别严重的或是早发型子痫前期、妊娠后几十年母亲视网膜疾病发生高风险相关。

最近,妇产科领域权威杂志Obstetrics and Gynecology上发表了一篇研究文章,旨在评估子痫前期是否与妊娠后数十年母亲视网膜疾病的发生风险存在相关性。

研究人员进行了一项纵向队列研究,于1989年至2013年期间在加拿大魁北克省各个医院进行分娩的1,108,541名妇女纳入研究。研究人员调查追踪了作为研究对象的妇女之后的住院情况,随访时间截止到2014年3月31日。在分娩时对子痫前期进行测量,并根据严重程度(轻度或重度)和发病时间(之前或34周或34周以上的妊娠)进行分类。

主要终点事件为住院治疗和因视网膜脱离、视网膜病变或其他视网膜疾病而住院治疗。研究人员采用Cox回归模型估计子痫前期孕妇与无子痫前期孕妇比较而得的危险比和95%可信区间,并对糖尿病和高血压等因素进行了调整。

与无子痫前期孕妇相比,有子痫前期的妇女几十年后有较高的因视网膜脱离(52.9 vs. 23.9/10000人)、视网膜病变(60.5 vs. 8.0/10000人)和其他视网膜疾病(13.3 vs. 7.3/10000人)而住院治疗的发生率。


子痫前期与视网膜牵引脱离(风险比为2.39,95%可信区间为1.52-3.74)、视网膜裂孔(风险比为2.48,95%可信区间为1.40-4.41),以及糖尿病视网膜病变(风险比为4.13,95%可信区间为3.39-5.04)密切相关。与轻度或晚发型子痫前期相比,重度早发型子痫前期和有更高的视网膜疾病发生风险相关。

由此可见,子痫前期,特别严重的或是早发型子痫前期,妊娠后几十年母亲视网膜疾病发生高风险相关。

原始出处:

Auger, Nathalie, et al. Preeclampsia and Long-term Risk of Maternal Retinal Disorders. obstetrics and gynecology. December 02, 2016.

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    2017-05-21 yhy100200
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    2016-12-10 zutt
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    2016-12-10 yahu
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    2016-12-09 半夏微凉

    学习了,继续关注!

    0

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