Hum Reprod:手术治疗子宫内膜异位症可降低心血管疾病风险

2014-07-07 desperado-c 丁香园

一项小型研究显示子宫内膜异位症手术治疗后,患者内皮细胞功能有改善。来自意大利的研究者称,这些潜在的获益可能会降低患者心血管疾病风险。罗马天主教大学的Luca Santoro教授在写给路透健康社邮件指出,“子宫内膜异位症可能与血管功能障碍有关,这个观点需要更广泛地被妇产科医师所熟知,同时,还应包括对子宫内膜异位症患者心血管疾病筛查的仔细评估。”这项研究在线发表在2014年04月28日的Human R

一项小型研究显示子宫内膜异位症手术治疗后,患者内皮细胞功能有改善。来自意大利的研究者称,这些潜在的获益可能会降低患者心血管疾病风险。

罗马天主教大学的Luca Santoro教授在写给路透健康社邮件指出,“子宫内膜异位症可能与血管功能障碍有关,这个观点需要更广泛地被妇产科医师所熟知,同时,还应包括对子宫内膜异位症患者心血管疾病筛查的仔细评估。”

这项研究在线发表在2014年04月28日的Human Reproduction 杂志上。该研究中,Santoro教授及其同事注意到子宫内膜异位症与动脉粥样硬化有关。

Santoro教授指出,他们之前的研究发现子宫内膜异位症患者多伴有内皮细胞功能障碍,表现为患者血流依赖性舒张功能(FMD)受损,这也被认为是亚临床动脉粥样硬化。

该研究中,子宫内膜异位症患者手术治疗后,Santoro教授等对这些患者亚临床动脉粥样硬化指标可能出现的变化进行检测,并同时对患者进行随访。最终,研究共纳入了22例行手术治疗的子宫内膜异位症患者和10例非子宫内膜异位症对照者。

手术治疗2年后,与基线相比,子宫内膜异位症患者的FMD显著增加,平均增加5.07%;而对照组患者FMD仅增加了1.56%。此外,子宫内膜异位症患者与对照者之间的FMD随访值没有显著差异。而且,两组间炎症指标和内皮细胞活化指标也相似。

Santoro教授称,“我们的研究结果让我们假设,子宫内膜异位症患者手术治疗后内皮细胞功能的改善可能对心血管疾病风险变化有预后意义。但同时,也需要进一步的纵向研究确定这些女性患者发生心血管事件的真实风险。”

原始出处:

Santoro L1, D'Onofrio F, Campo S, Ferraro PM, Flex A, Angelini F, Forni F, Nicolardi E, Campo V, Mascilini F, Landolfi R, Tondi P, Santoliquido A.Regression of endothelial dysfunction in patients with endometriosis after surgical treatment: a 2-year follow-up study.Hum Reprod. 2014 Jun;29(6):1205-10. doi: 10.1093/humrep/deu074. Epub 2014 Apr 28.

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    2014-07-09 sunylz
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    2014-07-08 sunxiaofei4457

    有意思,子宫内膜异位和心血管疾病之间的联系?!

    0

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