Nat Commun:多个前列腺肿瘤具有不同的药物敏感性报道

2020-02-25 AlexYang MedSci原创

局部前列腺癌在遗传上是可变的,并且经常是具有多个病灶的,包括空间上不同的区域且具有多个独立进化的克隆。到目前为止,是否上述可变性能够影响前列腺肿瘤患者的治疗决策仍旧不清楚。最近,有研究人员报道了一个新辅助强雄激素阻断治疗的临床试验案例。该患者通过成像被诊断为具有大的半连续性肿瘤,组织学上包括一个大的格林森评分为9的肿瘤和一个临近的格林森评分为7的小瘤。DNA测序阐释了上述两个肿瘤为独立的肿瘤,且只

局部前列腺癌在遗传上是可变的,并且经常是具有多个病灶的,包括空间上不同的区域且具有多个独立进化的克隆。到目前为止,是否上述可变性能够影响前列腺肿瘤患者的治疗决策仍旧不清楚。

最近,有研究人员报道了一个新辅助强雄激素阻断治疗的临床试验案例。该患者通过成像被诊断为具有大的半连续性肿瘤,组织学上包括一个大的格林森评分为9的肿瘤和一个临近的格林森评分为7的小瘤。DNA测序阐释了上述两个肿瘤为独立的肿瘤,且只有格林森评分为9的肿瘤具有PTEN和TP53的单拷贝缺失。PTEN/TP53缺陷肿瘤阐释了PTEN和TP53剩余拷贝变异亚克隆赋予了治疗抗性,而格林森评分为7的PTEN完整性肿瘤则几乎完全消融。

最后,研究人员指出,他们的发现阐释了空间遗传可变性是前列腺癌患者个性化治疗的一个主要干扰因素。

原始出处:

Scott Wilkinson, Stephanie A. Harmon, Nicholas T. Terrigino et al. A case report of multiple primary prostate tumors with differential drug sensitivity. Nat Commun. 13 Feb 2020

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    2020-03-31 liuli5079
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    2020-08-31 liye789132251
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