Neurology:脑中风后行血管内血栓切除术后,脑微出血的存在和预后无关

2021-02-01 Freeman MedSci原创

脑中风后行血管内血栓切除术后,脑微出血的存在和预后无关

通过血液敏感的MRI序列检测到的脑微出血(CMBs),它和局灶性血栓素沉积对应,这可能是由于以前异常小血管渗漏造成的,是易出血的小血管疾病(SVD)的标志。

静脉溶栓后的卒中患者发生颅内出血(ICH)的风险,已与CMB负担有关,但在这类高CMB负担(通常>10个CMB)的患者中,静脉注射组织凝血酶原激活剂(tPA)的获益-风险比仍不清楚。此外,CMB负担对急性缺血性卒中(AIS)血管内血栓切除术(EVT)后ICH风险的假想影响仍然未知。

藉此,法国Hôpital Gui de Chauliac的Imad Derra等人,探究EVT前CMB的存在和负担是否与ICH和AIS后3个月的临床结果相关。此外,还探究了CMBs对成功再灌注患者结局的临床影响,在这些患者中,CMBs可能对结局有更显著的影响。

他们回顾性分析了连续接受EVT治疗前循环AIS的患者。并使用有效的量表对T2*-MRI上的CMBs进行评级。同时分析了CMB的存在和负担与ICH和3个月时的不良临床结果(mRankin评分>2)的关系。

结果显示,在513名患者中,281名(54.8%)的结果不佳,89名(17.3%)的CMBs≥1。
共有190名(37%)患者发生ICH,其中66名(12.9%)有症状。在单变量分析中,CMB负担与不良结局相关(OR1.18;P=0. 02),但在调整性别、年龄、卒中严重程度、高血压、糖尿病、房颤、既往抗血栓药物、静脉溶栓和再灌注状态后,失去了显著性(OR1.05;P=0.50)。

当考虑到CMB位置或推测的潜在发病机制时,结果仍无显著性。CMB的存在、负担、位置以及假定的发病机制均与ICH独立相关。

这个研究的重要意义在于,脑中风后,EVT前MRI的CMB存在或负担,和功能结果差或ICH不相关,将此类患者排除在再灌注治疗之外是没有依据的。

原文出处:

Microbleeds, Cerebral Hemorrhage, and Functional Outcome after Endovascular Thrombectomy ; Imad Derraz; et al. Neurology Jan 2021, 10.1212/WNL.0000000000011566; DOI: 10.1212/WNL.0000000000011566

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    2021-02-28 yinhl1978
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    2021-02-01 Jessie Zhang

    这个研究的重要意义在于,脑中风后,EVT前MRI的CMB存在或负担,和功能结果差或ICH不相关,将此类患者排除在再灌注治疗之外是没有依据的

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1877378, encodeId=d32818e737846, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Sun Jun 27 22:50:23 CST 2021, time=2021-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1674869, encodeId=3b7e16e486961, content=<a href='/topic/show?id=60fb50501b3' target=_blank style='color:#2F92EE;'>#微出血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50501, encryptionId=60fb50501b3, topicName=微出血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5c7927121733, createdName=liuxiaona, createdTime=Sat Sep 18 10:50:23 CST 2021, time=2021-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001230, encodeId=526d200123084, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sun Feb 28 04:50:23 CST 2021, time=2021-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314296, encodeId=601613142962a, content=<a href='/topic/show?id=585189089f4' target=_blank style='color:#2F92EE;'>#血栓切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89089, encryptionId=585189089f4, topicName=血栓切除)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=284b425, createdName=zll0625, createdTime=Tue Feb 02 19:50:23 CST 2021, time=2021-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1393556, encodeId=913f139355665, content=<a href='/topic/show?id=7ee28485472' target=_blank style='color:#2F92EE;'>#脑微出血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84854, encryptionId=7ee28485472, topicName=脑微出血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d0b2500136, createdName=12498b08m90暂无昵称, createdTime=Tue Feb 02 19:50:23 CST 2021, time=2021-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401047, encodeId=0a78140104e90, content=<a href='/topic/show?id=4a328909094' target=_blank style='color:#2F92EE;'>#血栓切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89090, encryptionId=4a328909094, topicName=血栓切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Tue Feb 02 19:50:23 CST 2021, time=2021-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481027, encodeId=d644148102e6a, content=<a href='/topic/show?id=09498955872' target=_blank style='color:#2F92EE;'>#血管内血栓切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89558, encryptionId=09498955872, topicName=血管内血栓切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa8d7728463, createdName=1179102698_36768928, createdTime=Tue Feb 02 19:50:23 CST 2021, time=2021-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=921978, encodeId=a43a9219e8d8, content=这个研究的重要意义在于,脑中风后,EVT前MRI的CMB存在或负担,和功能结果差或ICH不相关,将此类患者排除在再灌注治疗之外是没有依据的, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/5008534db22c474a844fbd107ff83af2/d3e20fc133b542208ff15e7f2b575329.jpg, createdBy=c7015311102, createdName=Jessie Zhang, createdTime=Mon Feb 01 16:45:18 CST 2021, time=2021-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046014, encodeId=193010460144c, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Mon Feb 01 07:50:23 CST 2021, time=2021-02-01, status=1, ipAttribution=)]
    2021-02-01 guging

    中风是俗称,应该称为缺血性卒中吧

    0

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