Indian J Dent Res:ώ-3脂肪酸在慢性牙周炎治疗中的辅助治疗功效

2020-06-24 MedSci原创 MedSci原创

牙周炎的传统治疗方法有手术和非手术两种。以前曾使用过各种辅助药物,但效果不佳。最近ω-3(ώ-3)多不饱和脂肪酸(PUFA),包括二十二碳六烯酸(DHA)和二十碳五烯酸(EPA)被证明对包

牙周炎的传统治疗方法有手术和非手术两种。以前曾使用过各种辅助药物,但效果不佳。最近ω-3(ώ-3)多不饱和脂肪酸(PUFA),包括二十二碳六烯酸(DHA)和二十碳五烯酸(EPA)被证明对包括牙周炎在内的炎症性疾病具有治疗性抗炎和保护作用。本研究旨在评估和比较ώ-3脂肪酸作为辅助洗牙和根部刨除治疗牙周炎的临床疗效。

 

研究筛选了110名患者,其中20人被排除在外(12人不符合纳入标准,8人拒绝参与)。通过掷硬币法随机化后的90名患者(试验组48名,对照组42名)被纳入某口腔学院牙周科进行的单盲随机对照试验。给予试验组全口龈下洁治和根面平整,并给予ώ-3脂肪酸500 mg(EPA/DHA 180/120 mg),BD每日1个月,对照组仅给予龈下洁治和根面平整。在基线、1个月和3个月分别记录探诊深度、临床附着水平、菌斑指数和牙龈指数等临床参数,并进行比较。

 

结果显示,与基线和对照组相比,试验组在1个月(t = 65.56,P = 0.000)和3个月时(t = 51.69,P = 0.000)探诊深度显著减少。与基线组和对照组相比,试验组在1个月(t=63.29,P=0.000)和3个月时(t=31.03,P=0.000),临床附着水平有明显的提高。两组牙龈指数均有明显下降,在试验组中,3个月时有统计学意义(t = 2.15,P = 0.03)。菌斑指数在3个月时无统计学意义的降低(t = 0,P = 0.997)。

 

总之,该研究表明,在治疗慢性中度牙周炎的过程中,辅助使用ώ-3脂肪酸被证明比单独洁治和根面平整有益。其有益效果体现在临床参数、探查袋深度、临床附着水平和牙龈指数的显著改善上。目前,饮食调理正成为牙周治疗的辅助手段。因此,ω-3脂肪酸可常规用于慢性牙周炎的治疗。

 

原始出处:

 

Shirish K Kujur, Varsha Goswami, et al., Efficacy of Omega 3 Fatty Acid as an Adjunct in the Management of Chronic Periodontitis: A Randomized Controlled Trial. Indian J Dent Res. Mar-Apr 2020;31(2):229-235. doi: 10.4103/ijdr.IJDR_647_18.

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    2020-06-25 xiaogang319

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总体而言,长期膳食摄入鱼类和ω-3脂肪酸与中老年男性高血压发生无关。

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本篇论文同样发表在《新英格兰医学杂志》上,牛津大学的研究者们分析ASCEND数据发现,约1.5万糖尿病患者,在7.4年随访期间,每日服用1g Omega-3脂肪酸补剂与1g橄榄油的患者相比,在心血管疾病发病率及全因死亡率上,并没有表现出显着差异。

AHA2019丨ω-3脂肪酸再续“传奇”,降低心血管事件显获益

AHA 2019大会的多项最新研究结果已陆续发布。其中,REDUCE-IT研究显示,在高甘油三酸酯(TGs)和已知心血管疾病或高发病风险以及已接受他汀类药物治疗低密度脂蛋白胆固醇(LDL-C)水平控制相对良好的患者中,使用一种高剂量纯化形式的ω-3脂肪酸(Icosapent Ethyl)可降低TGs,心血管事件和心血管死亡。REDUCE-IT研究的目的是评估在TGs患者中,与安慰剂相比,Icosa