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Clinica Chimica Acta：马丁方程对埃及2型糖尿病患者LDL-C估计的评价

2019-09-22 gladiator MedSci原创

糖尿病肥胖
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2型糖尿病具有特征性血脂异常。低密度脂蛋白胆固醇(LDL-C)测量在心血管风险评估和管理中发挥着重要作用。而弗里德瓦尔德方程(FE)有几个局限性。本研究旨在评估马丁方程(ME)在埃及患者，尤其是2型糖尿病患者中的有效性。

2型糖尿病具有特征性血脂异常。低密度脂蛋白胆固醇(LDL-C)测量在心血管风险评估和管理中发挥着重要作用。而弗里德瓦尔德方程(FE)有几个局限性。本研究旨在评估马丁方程(ME)在埃及患者，尤其是2型糖尿病患者中的有效性。

研究人员采用横断面研究方法，对454例糖尿病患者和非糖尿病患者进行了内科门诊治疗。采用Cobas 8000模块分析仪测定血脂。用FE和ME对LDL-C进行了估计。

LDL-C是由Fe和ME估计的。在糖尿病患者中，通过FE计算的LDL-C出现低估，且偏倚为−3.9 ± 5.3 mg/dL (p = .04)。但LDL-C相比直接测量LDL-C由ME没有显著不同。非对照的糖尿病患者FE低估LDL-C且偏倚为−4.6 ± 6.4 mg/dL (p = .042)。ME检测到对照组与非对照组之间无显著性差异。 与ME (95.9% sensitivity, and 95.6% specificity)相比，FE的敏感性和特异性较低(80% and 88.9 respectively)。 ME不受甘油三酯水平的影响（P = 0.34）。

研究表明，ME改善了埃及糖尿病患者计算的LDL-C与直接LDL-C测定的一致性。

原始出处：

Marwa M. Esawy，Marwa A. Shabana，Evaluation of Martin's equation for LDL-C estimation in type 2 diabetes mellitus Egyptian patients

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    2020-08-24 12498d2fm58(暂无昵称)

    #埃及#

    0

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    2019-11-29 windight

    #CTA#

    0

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    2019-09-27 最帅小男护

    学习了

    0

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    2019-09-24 一天没事干

    很好的学习机会

    0

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    2019-09-24 aids213

    #2型糖尿病患者#

    0

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    2019-09-24 zhwj

    #LDL#

    0

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    2019-09-24 huagfeg

    #评价#

    0

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    2019-09-24 xue8604

    #糖尿病患者#

    0

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    2019-09-22 misszhang

    谢谢MedSci提供最新的资讯

    0

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