Lancet:中国大陆地区COPD发病率及风险因素研究

2018-04-10 zhangfan MedSci原创

研究发现,通过肺活量考察中国成人慢性阻塞性肺病的发病率较高,吸烟、空气污染、体重低、儿童慢性咳嗽、父母肺疾病史以及教育程度低都是导致COPD发病的风险因素

近日研究人员通过中国肺健康研究计划(CPH)考察了中国成人慢性阻塞性肺病(COPD)的患病率及风险因素。

来自中国大陆10个省市的20岁以上人群参与研究,所有参与者接受支气管扩张后肺功能测试,根据2017全球慢性阻塞性肺病(GOLD) 诊断标准对参与者COPD情况进行考察。

2012-15年间,50991名参与者(男性21446人,女性29545人)接受支气管扩张,其结果纳入最终分析。根据肺活量测定结果,中国成人COPD总发病率为8.6%,意味着中国约存在9990万COPD患者。男性发病率高于女性(11.9 vs 5.4%)、40岁以上人群发病率高于20-39岁人群(13.7 vs 2.1%)。仅12%的COPD患者先前接受过肺功能测试。COPD风险因素包括20年以上烟草暴露史(OR 1.95)、年PM2.5平均50-74 μg/m3 (1.85)、年PM2.5平均大于75μg/m3 (2.00)、体重指数<18.5(1.43)、儿童慢性咳嗽(1.48)、儿童经常性咳嗽(2.57)以及父母肺病史(1.40)。教育程度提高与较低的COPD风险相关(中学以上教育程度OR 0.76,大学以上教育程度OR 0.47)。

研究发现,通过肺活量考察中国成人慢性阻塞性肺病的发病率较高,吸烟、空气污染、体重低、儿童慢性咳嗽、父母肺疾病史以及教育程度低都是导致COPD发病的风险因素。

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    2021-03-03 ms1000000419058267

    8.6%是患病率 Prevelance,不是发病率

    0

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    2018-12-13 howi
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    2018-04-11 flysky120

    慢性阻塞性肺疾病是很多和生活环境和生活习惯(吸烟)

    0

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    2018-04-11 871538379

    学习到COPD的全国患病情况

    0

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    2018-04-11 雅文博武

    学习了很多先进的医学研究

    0

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电子香烟一直以来是医学上及大众中常见的卷烟代替物用来戒烟过渡物,但一直以来其对人体呼吸道的具体影响并不清楚,本研究通过对电子烟烟雾提取物刺激人类支气管上皮细胞,并发现该提取物的毒性反应机制,引起了同仁的高度重视。

PNAS:CRISPR技术帮助创建慢性阻塞性肺病的小鼠模型

慢性阻塞性肺病 (chronic obstructive pulmonary diseases, COPD) 影响着全世界10%的人口的生活。其中最主要的遗传原因是由于基因变异导致的α-1抗胰蛋白酶 (α-1 antitrypsin, ATT) 缺乏症,它会造成患者出现遗传性肺气肿 (emphysema) 。

Eur Respir J:心血管自主神经功能障碍标志可预测中年人慢性阻塞性肺病!

由此可见,中年人心血管自主神经功能障碍的细微征象可能先于COPD的发展。这种关联独立于心血管自主功能障碍与CAD之间的关系。

Chest:COPD患者的虚弱感是否有意义?

老年人常常会感到虚弱,其特点是生理储备减少,易受应激物质伤害。虚弱可以改变包括慢性阻塞性肺病(COPD)在内的几种慢性疾病的预后和治疗方法。但是,虚弱与COPD之间的关联从未进行系统的审查。近期,一项发表在杂志Chest上的研究进行了系统评价和荟萃分析,评估COPD与虚弱以及虚弱前之间的关联。研究者们使用了PRISMA指南。自2002年1月1日至2017年10月6日之间搜索了PubMed,Web

Eur Heart J-Card Img:慢性阻塞性肺疾病急性心肌梗死后左室整体纵向应变与长期预后!

由此可见,左心室GLS受损与伴有COPD的STEMI患者糟糕的长期生存率独立相关,并会增加LVEF的预测价值。

Chest:预测肺癌的慢性阻塞性肺疾病临床特征!

由此可见,COPD严重程度,包括气流阻塞、肺气肿和呼吸功能恶化都是肺癌的独立预测因素。这些危险因素应作为肺癌筛查生存获益的纳入标准和排除标准开展进一步研究。同时,需要进行研究来确定减少吸烟者呼吸功能恶化是否能降低肺癌风险。