Oral Dis:口服益生菌是否能有效治疗牙龈炎?

2022-06-01 sunshine MedSci原创

牙斑生物膜和宿主的免疫炎症反应共同促进了牙斑诱发的牙龈炎的发展。益生菌是能够维持微生态平衡并赋予宿主健康益处的活的微生物,这不仅包括重建微生物群落,还包括调节免疫-炎症反应。

牙斑生物膜和宿主的免疫炎症反应共同促进了牙斑诱发的牙龈炎的发展。益生菌是能够维持微生态平衡并赋予宿主健康益处的活的微生物,这不仅可以重建微生物群落,还可以调节免疫-炎症反应。在口腔方面,益生菌的有益作用包括改善生物膜的质量和调控宿主的炎症反应。近日,发表于Oral Dis的一项系统回顾和荟萃分析评估益生菌对斑块诱发的牙龈炎患者的牙龈炎症和口腔微生物群的影响。

研究人员检索了2020年12月PubMed、Cochrane中央对照试验注册中心(CENTRAL)和EMBASE数据库中收录的相关文章。纳入研究的质量使用Cochrane合作组织的偏见风险工具评估。差异以加权平均差异(WMD)和95%的置信区间(95% CI)表示。进行I2检验以评估研究的异质性。

结果,研究共纳入了11项随机和对照试验,包括554名患者。分析结果显示,口服益生菌并没有显著改善菌斑引起的牙龈炎患者的牙龈指数(GI)、菌斑指数(PI)和探诊出血(BOP)。在微生态学方面,益生菌组和安慰剂组在牙龈龈沟液(GCF)的、IL-1β的浓度以及放线聚集杆菌(Aa)、牙龈卟啉单胞菌(Pg)、中间普氏菌(Pi)和具核梭杆菌(Fn)的数量上没有发现明显的差异。

综上所述,该研究结果表明,目前没有明确的证据表明口服益生菌对牙龈炎症和菌斑诱发的牙龈炎患者的口腔微生态环境有积极作用。需要精心设计的RCTs进一步探究该问题以得出明确的结论。

原始出处:

Jiaxuan Liu, et al., Effect of probiotics on gingival inflammation and oral microbiota: A meta-analysis. Oral Dis. 2022 May;28(4):1058-1067. doi: 10.1111/odi.13861.  

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2013887, encodeId=adc5201388e50, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Wed Apr 19 23:00:36 CST 2023, time=2023-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2020704, encodeId=fb8d2020e04d4, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Sat Feb 25 06:00:36 CST 2023, time=2023-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351519, encodeId=c3421351519b3, content=<a href='/topic/show?id=d1c76e735bf' target=_blank style='color:#2F92EE;'>#牙龈炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67735, encryptionId=d1c76e735bf, topicName=牙龈炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon May 30 13:00:36 CST 2022, time=2022-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619645, encodeId=a420161964588, content=<a href='/topic/show?id=8dd46061824' target=_blank style='color:#2F92EE;'>#有效治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60618, encryptionId=8dd46061824, topicName=有效治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Mon May 30 13:00:36 CST 2022, time=2022-05-30, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=2013887, encodeId=adc5201388e50, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Wed Apr 19 23:00:36 CST 2023, time=2023-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2020704, encodeId=fb8d2020e04d4, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Sat Feb 25 06:00:36 CST 2023, time=2023-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351519, encodeId=c3421351519b3, content=<a href='/topic/show?id=d1c76e735bf' target=_blank style='color:#2F92EE;'>#牙龈炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67735, encryptionId=d1c76e735bf, topicName=牙龈炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon May 30 13:00:36 CST 2022, time=2022-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619645, encodeId=a420161964588, content=<a href='/topic/show?id=8dd46061824' target=_blank style='color:#2F92EE;'>#有效治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60618, encryptionId=8dd46061824, topicName=有效治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Mon May 30 13:00:36 CST 2022, time=2022-05-30, status=1, ipAttribution=)]
    2023-02-25 小几洁
  3. [GetPortalCommentsPageByObjectIdResponse(id=2013887, encodeId=adc5201388e50, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Wed Apr 19 23:00:36 CST 2023, time=2023-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2020704, encodeId=fb8d2020e04d4, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Sat Feb 25 06:00:36 CST 2023, time=2023-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351519, encodeId=c3421351519b3, content=<a href='/topic/show?id=d1c76e735bf' target=_blank style='color:#2F92EE;'>#牙龈炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67735, encryptionId=d1c76e735bf, topicName=牙龈炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon May 30 13:00:36 CST 2022, time=2022-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619645, encodeId=a420161964588, content=<a href='/topic/show?id=8dd46061824' target=_blank style='color:#2F92EE;'>#有效治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60618, encryptionId=8dd46061824, topicName=有效治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Mon May 30 13:00:36 CST 2022, time=2022-05-30, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=2013887, encodeId=adc5201388e50, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Wed Apr 19 23:00:36 CST 2023, time=2023-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2020704, encodeId=fb8d2020e04d4, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Sat Feb 25 06:00:36 CST 2023, time=2023-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351519, encodeId=c3421351519b3, content=<a href='/topic/show?id=d1c76e735bf' target=_blank style='color:#2F92EE;'>#牙龈炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67735, encryptionId=d1c76e735bf, topicName=牙龈炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon May 30 13:00:36 CST 2022, time=2022-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619645, encodeId=a420161964588, content=<a href='/topic/show?id=8dd46061824' target=_blank style='color:#2F92EE;'>#有效治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60618, encryptionId=8dd46061824, topicName=有效治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Mon May 30 13:00:36 CST 2022, time=2022-05-30, status=1, ipAttribution=)]

相关资讯

Brit J Cancer:用于预测结直肠肿瘤风险的微生物标志物

该综述提供了支持不同类型微生物物种之间关联的证据及其对结直肠肿瘤的预测价值的观点。从病例对照研究开发的预测模型需要在高质量的前瞻性研究中开展进一步的外部验证。

A&R:宿主遗传学而非共生微生物群决定了BXD2小鼠系统性自身免疫性疾病的初步发展

在狼疮小鼠模型中发现遗传学在确定自身免疫的初始发展中起主导作用。相比之下,肠道微生物组可以调节系统性自身免疫某些方面的持久性。

JGH: 肠道微生物群衍生合生元配方 (SIM01) 可以作为COVID-19的新型辅助疗法

肠道菌群是指定植在人体肠道内并长期与人体相互依存的细菌群,包括40多个菌属,400到500种菌种,数量达100万亿之多,是人体细胞的10倍,重量上相当于一个人的肝脏。

Arthritis Rheumatol:类风湿关节炎患者与健康人的口腔微生物差别

与健康对照组相比,早期 RA 患者和RA高危个体的口腔微生物组相似,两者口腔微生物的特征是潜在促炎菌种的相对丰度升高。