DIABETOLOGIA：年轻女性的妊娠期糖尿病可预示未来患严重肝病的风险？

2019-05-06 不详网络

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与2型糖尿病一样，妊娠期糖尿病(GDM)与肝脂肪沉积的倾向有关。我们假设GDM可以预测严重肝病(如肝硬化、肝功能衰竭和需要移植)的终生风险。

从基于人口的管理数据库中，我们确定了加拿大安大略省所有在1994年4月至2002年3月期间因怀孕而活产的妇女(N = 698,078)。这一人群被分层为有GDM(n = 17,932)和无(n = 680,146) 的个体，两组在分娩后的几年内，根据随后2型糖尿病的发展情况进一步分层。严重肝病(定义为肝硬化、肝功能衰竭或移植)发展的中位随访时间为14.0年。

研究显示，与没有GDM和没有患糖尿病(n = 635998)女性相比，有GDM的妇女比没有GDM的妇女患严重肝病的风险更高(n = 680,146;HR = 1.40, 95% CI 1.01, 1.94)。和那些没有GDM了2型糖尿病(n = 44148;调整后的HR = 2.48, 95% CI 2.10, 2.93)，但没有发展成2型糖尿病的GDM患者(n = 9365;调整后的HR = 1.15, 95% CI 0.69, 1.91)相比，那些有GDM患随后发展为2型糖尿病(n = 8567)的患者有严重肝脏疾病的风险更高(调整HR = 1.56, 95% CI 1.02, 2.39)。

研究表明，GDM与未来年轻女性发生严重肝病的风险相关，其发展可能依赖于非妊娠期糖尿病的进展。

原始出处：

Ravi Retnakaran, Jin Luo,Gestational diabetes in young women predicts future risk of serious liver disease

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2020-04-20 ms9608593228839890

#DIA#

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2019-05-10 ms5439512287675881

#BET#

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2019-05-08 wjcjjian

#妊娠期#

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2019-05-08 shenxlcyp

#妊娠期糖尿病#

34 0
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2019-05-08 thinkibmz_44722597

#年轻女性#

44 0
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2019-05-07 misszhang

谢谢MedSci提供最新的资讯

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